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oa Synthesis and stereochemistry of 6-membered ring phosphonates
- Source: QScience Connect, Volume 2012, Issue 1, Jan 2012, 2
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- 23 December 2011
- 27 February 2012
- 05 March 2012
Abstract
Abstract
Background: Organophosphorus compounds have important industrial and biomedical applications as pharmaceutical and agrochemical agents, as well as transition state analogs for the production of monoclonal antibodies.
Methods: Two diastereomers of a 6-membered ring, cyclic phenyl phosphonate were synthesized in 8 steps from 1,3-butanediol.
Results: The stereochemistry of the diastereomers was elucidated on the basis of P NMR signals, together with H NMR nuclear Overhauser effects (NOE) difference experiments.
Conclusions: Such cyclic phosphonates may have utility serving as transition state analogs for the production of monoclonal antibodies.
© 2012 Pungente and Weiler, licensee Bloomsbury Qatar
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