1887
  1. Home
  2. A-Z Publications
  3. Journal of Emergency Medicine, Trauma and Acute Care
  4. Volume 2022, Issue 4
  5. Article
Volume 2022, Issue 4
  • ISSN: 1999-7086
  • EISSN: 1999-7094

Abstract

Recently, biological dressings have become popular in treating burn injuries. Fish skin has non-infectious microbiota, high levels of type 1 and type 3 collagen, and a structural property similar to human skin, making it a promising xenograft for managing burn wounds. In this study, we aimed to evaluate the effectiveness of fish skin as a physiological dressing cover in patients with burn injuries. From June 2017 to June 2021, 18 patients who were admitted to our center within 3 days from a thermal injury, burns with a partial thickness of approximately 20% of the total body surface area (TBSA) or complete partial-thickness burns ranging from 5% to 15% of the TBSA, and treated with the Shaour () fish skin xenografts were enrolled in this retrospective study. The demographic characteristics of the participants, wound healing process, and final outcome were analyzed. The mean age of the patients was 31.86 ± 9.14 years (range 19–46) which encompassed 12 (66.7%) men and 6 (33.3%) women. Superficial partial-thickness burns were seen in 13 (72.2%) patients, whereas full-thickness burns were seen in five (27.8%) patients. The mean time to 90% epithelialization and 100% epithelialization were 11.05 ± 2.57 days and 17.27 ± 2.05 days, respectively. The mean pain scores were 6.94 ± 0.72 and 5.22 ± 0.64 on days 7 and 15, respectively. Neither negative consequence nor allergic reaction was associated with using the fish skin grafts. The main reduction in the pain score from the first visit (7 days) to the second visit (15 days) was 1.72 ± 0.95 ( <  0.001). Acellular fish skin is a useful tool for wound healing treatment in complete and partial thickness burns. To validate this result, prospective cohort studies with long-term post-procedural follow-up are needed.

© 2022 Kotkot, Ghabisha, Ahmed, Al-wageeh, Al-shami, Al-hajri, Aljbri, Mohammed, licensee HBKU Press.
Loading

Article metrics loading...

/content/journals/10.5339/jemtac.2022.18
2022-06-30
2024-11-17
Loading full text...

Full text loading...

/deliver/fulltext/jemtac/2022/4/jemtac.2022.18.html?itemId=/content/journals/10.5339/jemtac.2022.18&mimeType=html&fmt=ahah

References

  1. Lima Júnior EM, De Moraes Filho MO, Costa BA, Rohleder AVP, Sales Rocha MB, Fechine FV, et al. Innovative burn treatment using Tilapia skin as a xenograft: A phase II randomized controlled trial. J Burn Care Res. 2020;:41:585–92.
     [Google Scholar]
  2. Alam K, Jeffery SLA. Acellular fish skin grafts for management of split thickness donor sites and partial thickness burns: A case series. Mil Med. 2019;:184:16–20.
     [Google Scholar]
  3. Baldursson BT, Kjartansson H, Konrádsdóttir F, Gudnason P, Sigurjonsson GF, Lund SH. Healing rate and autoimmune safety of full-thickness wounds treated with fish skin acellular dermal matrix versus porcine small-intestine submucosa: a noninferiority study. Int J Low Extrem Wounds. 2015;:14:37–43.
     [Google Scholar]
  4. Yang CK, Polanco TO, Lantis JC 2nd. A prospective, postmarket, compassionate clinical evaluation of a novel acellular fish-skin graft which contains omega-3 fatty acids for the closure of hard-to-heal lower extremity chronic ulcers. Wounds. 2016;:28:112–8.
     [Google Scholar]
  5. Younis EM, Abdel-Warith AA, Al-Asgah NA, Gabr MH, Shamlol FS. Demographic structure and stock status of Lethrinus lentjan in Saudi coastal waters of the Red Sea. Saudi J Biol Sci. 2020;:27:2293–8.
     [Google Scholar]
  6. Heba H, Abu Zeid I, Abuzinadah O, Farajalla A, Al-Hasawi Z. Determination of some heavy Metals in tissues and organs of three commercial fish species at Al-Hudaydah, Red Sea Coast of Western Yemen. J World. 2015;:7:198–208.
     [Google Scholar]
  7. Pakingking Jr R, Palma P, Usero R. Aeromonas load and species composition in tilapia Oreochromis niloticus) cultured in earthen ponds in the Philippines. Aquac Res. 2020;:51:4736–47.
     [Google Scholar]
  8. Wang P, Li J, He TT, Li N, Mo ZL, Nie P, et al. Pathogenic characterization of Aeromonas salmonicida subsp. masoucida turbot isolate from China. J Fish Dis. 2020;:43:1145–54.
     [Google Scholar]
  9. Alghabshi A, Austin B, Crumlish M. Aeromonas salmonicida isolated from wild and farmed fish and invertebrates in Oman. Int Aquat Res. 2018;:10:145–52.
     [Google Scholar]
  10. Ibrahim A, Hassan D, Kelany N, Kotb S, Soliman M. Validation of three different sterilization methods of Tilapia skin dressing: Impact on microbiological enumeration and collagen content. Front Vet Sci. 2020;:7:597751.
     [Google Scholar]
  11. Walker RW, Markillie LM, Colotelo AH, Geist DR, Gay ME, Woodley CM, et al. Ultraviolet radiation as disinfection for fish surgical tools. Anim Biotelemetry. 2013;:1:4.
     [Google Scholar]
  12. Pan SC. Burn blister fluids in the neovascularization stage of burn wound healing: A comparison between superficial and deep partial-thickness burn wounds. Burns Trauma. 2013;:1:27–31.
     [Google Scholar]
  13. Alomar AZ, Gawri R, Roughley PJ, Haglund L, Burman M. The effects of chlorhexidine graft decontamination on tendon graft collagen and cell viability. Am J Sports Med. 2012;:40:1646–53.
     [Google Scholar]
  14. Bigbie RB, Schumacher J, Swaim SF, Purohit RC, Wright JC. Effects of amnion and live yeast cell derivative on second-intention healing in horses. Am J Vet Res. 1991;:52:1376–82.
     [Google Scholar]
  15. Mann-Salinas EA, Joyner DD, Guymon CH, Ward CL, Rathbone CR, Jones JA, et al. Comparison of decontamination methods for human skin grafts. J Burn Care Res. 2015;:36:636–40.
     [Google Scholar]
  16. Anderson EJ, Thayne KA, Harris M, Shaikh SR, Darden TM, Lark DS, et al. Do fish oil omega-3 fatty acids enhance antioxidant capacity and mitochondrial fatty acid oxidation in human atrial myocardium via PPARγ activation? Antioxid Redox Signal. 2014;:21:1156–63.
     [Google Scholar]
  17. Laycock H, Valente J, Bantel C, Nagy I. Peripheral mechanisms of burn injury-associated pain. Eur J Pharmacol. 2013;:716:169–78.
     [Google Scholar]
  18. Retrouvey H, Shahrokhi S. Pain and the thermally injured patient-a review of current therapies. J Burn Care Res. 2015;:36:315–23.
     [Google Scholar]
  19. Chiu T, Burd A. “Xenograft” dressing in the treatment of burns. Clin Dermatol. 2005;:23:419–23.
     [Google Scholar]
  20. Alves A, Lima Jr EM, Piccolo NS, de Miranda MJB, Lima Verde MEQ, Ferreira Jr AEC, et al. Study of tensiometric properties, microbiological and collagen content in nile tilapia skin submitted to different sterilization methods. Cell Tissue Bank. 2018;:19:373–82.
     [Google Scholar]
  21. Ibrahim A, Soliman M, Kotb S, Ali MM. Evaluation of fish skin as a biological dressing for metacarpal wounds in donkeys. BMC Vet Res. 2020;:16:472.
     [Google Scholar]
  22. Lima Jr EM, de Moraes Filho MO, Costa BA, Fechine FV, de Moraes MEA, Silva Jr FR, et al. Innovative treatment using tilapia skin as a xenograft for partial thickness burns after a gunpowder explosion. J Surg Case Rep. 2019; 2019:–(6):rjz181.
     [Google Scholar]
  23. Michael S, Winters C, Khan M. Acellular fish skin graft use for diabetic lower extremity wound healing: A retrospective study of 58 ulcerations and a literature review. Wounds. 2019;:31:262–8.
     [Google Scholar]
  24. Kirsner RS, Margolis DJ, Baldursson BT, Petursdottir K, Davidsson OB, Weir D, et al. Fish skin grafts compared to human amnion/chorion membrane allografts: A double-blind, prospective, randomized clinical trial of acute wound healing. Wound Repair Regen. 2020;:28:75–80.
     [Google Scholar]
  25. Tihista S, Echavarría E. Effect of omega 3 polyunsaturated fatty acids derived from fish oil in major burn patients: A prospective randomized controlled pilot trial. Clin Nutr. 2018;:37:107–12.
     [Google Scholar]
  26. Badois N, Bauër P, Cheron M, Hoffmann C, Nicodeme M, Choussy O, et al. Acellular fish skin matrix on thin-skin graft donor sites: a preliminary study. J Wound Care. 2019;:28:624–8.
     [Google Scholar]
/content/journals/10.5339/jemtac.2022.18
Loading
Fish skin as a biological dressing for burn injuries
Journal of Emergency Medicine, Trauma and Acute Care 2022, 18 (2022); https://doi.org/10.5339/jemtac.2022.18
/content/journals/10.5339/jemtac.2022.18
/content/journals/10.5339/jemtac.2022.18
Loading

Data & Media loading...

Keyword(s): biological dressing, burns, Lethrinus lentjan, shaour fish skin and wound healing

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error