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Volume 2022, Issue 4
  • ISSN: 1999-7086
  • EISSN: 1999-7094

Abstract

To evaluate the effects of estrogen on the prognosis of patients with diffuse axonal injury due to severe traumatic brain injury. Triple-blind placebo-controlled randomized clinical trial study The study was conducted at the Neurosurgery Department of Imam Reza Hospital of Tabriz University of Medical Sciences A total of 200 patients were enrolled in the study Two hundred patients were randomly allocated into two cases, with a control group of 100 each. The case group daily received 8μg/kg of estrogen by nasogastric for three days and the control group only received a placebo. The Glasgow Coma Scale (GCS) at discharge, Glasgow Outcome Score (GOS) at discharge, and the GOS three months later were investigated to evaluate the effect of estrogen on patients with diffuse axonal injury (DAI) following traumatic brain injury (TBI) in the case and control group. It was shown that there is a significant difference between the case and control groups based on GCS at discharge (p-value = 0.007), GOS at discharge (p-value = 0.02), and GOS at a 3-months follow-up period (p-value = 0.025). Ten patients (5 patients in each group) died during the study. This study indicated the efficacy of estrogen in patients with Diffuse Axonal Injury (DAI) following TBI.

© 2022 Mirzaei, Sigaroudi, Salehpour, Aghazadeh, Shokouhi, Meshkini, Dafchahi, Aalizadeh, Alavi, licensee HBKU Press.
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2022-07-05
2024-11-17
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/content/journals/10.5339/jemtac.2022.23
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Estrogen can improve the prognosis of patients with diffuse axonal injury due to severe traumatic brain injury: A Randomized Triple-blind Placebo-controlled Trial
Journal of Emergency Medicine, Trauma and Acute Care 2022, 23 (2022); https://doi.org/10.5339/jemtac.2022.23
/content/journals/10.5339/jemtac.2022.23
/content/journals/10.5339/jemtac.2022.23
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Keyword(s): diffuse axonal injury, estrogen and Traumatic brain injury

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