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3 - Second Mustansiriyah International Dental Conference (MIDC 2023)
  • ISSN: 1999-7086
  • EISSN: 1999-7094

Abstract

Dental caries is one of preschool children’s significant common infectious chronic diseases. Early childhood caries (ECC) is the most prevalent chronic childhood disease worldwide. HNP 1-3 are part of the non-oxidative antimicrobial mechanisms of neutrophils and can increase innate immunity by stimulating pro-inflammatory responses. Interleukin-6 (IL-6) is a pleiotropic cytokine produced by various nonimmune and immune cells responsible for regulating many aspects of the local immune response.

This study was conducted to evaluate the salivary levels of HNP1–3 in children with dental caries and to study the effect of the HNP1–3 level on the secretion of IL-6 in this disease.

Eighty children 4-5 years old were enrolled in this study. They were divided into two groups; 40 children with ECC as the study group and 40 caries-free children as the control group who matched the study group in age and gender: oral examination and measurement of clinical parameters of caries experience determined by dmfs index. Saliva samples were taken from all subjects. ELISA assay was carried out to estimate salivary levels of HNP1–3 and IL-6.

The current study found a significant elevation (P<0.05) in mean levels of HNP1-3 and IL-6 among children with ECC compared to caries-free children. Moreover, salivary HNP1-3 level showed a significant positive correlation with IL-6. On the other hand, there was no significant correlation between HNP1-3 and dmfs, whereas there was a positive correlation with IL-6.

These findings indicated that high levels of HNP1–3 and IL-6 may play a crucial essential ECC, and a positive correlation between them confirms the effect of antimicrobial peptides on cytokine production.

© 2023 Kareem, Al-Ghurabi, licensee HBKU Press.
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2023-07-31
2024-07-17
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/content/journals/10.5339/jemtac.2023.midc.11
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Regulatory Role of Human Neutrophil Peptides (HNP1-3) on Interleukin-6 Production in Early Childhood Caries
Journal of Emergency Medicine, Trauma and Acute Care 2023, 11 (2023); https://doi.org/10.5339/jemtac.2023.midc.11
/content/journals/10.5339/jemtac.2023.midc.11
/content/journals/10.5339/jemtac.2023.midc.11
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Keyword(s): antimicrobial peptides, Early childhood caries, HNP 1–3, IL-6 and innate immune response

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