oa Design And Synthesis Of New Monoamine Oxidase Inhibitors As Potential Neuroprotective Agents

Background and Objectives: Monoamine oxidase (MAO) catalyzes the biodegradation of biogenic amine neurotransmitters and a variety of xenobiotic amines. Selective MAO B inhibitors are used in the treatment of Parkinson's disease and other neurodegenerative diseases while selective MAO A inhibitors are known antidepressants. Piperazine and pyrazole rings are common moieties in several MAO inhibitors. The chronic nature of these diseases raises a compelling need for new MAO inhibitors with improved pharmacokinetics and safety profiles. Therefore, the aim of this project is to design, synthesize, purify and elucidate the structure of a series of new piperazine and pyrazole derivatives with potential MAO inhibitory activity. Methods: Based on the literature review, a series of compounds was proposed for their potential MAO inhibitory activity. Different piperazine and pyrazole derivatives were chemically synthesized by conventional method or by the use of microwave initiator. The reactions were monitored with TLC and purified by liquid-liquid extraction and column chromatography. The structures were confirmed by FTIR and GC/MS. Results: The microwave-assisted synthesis gave a better yield comparing to the conventional synthesis. The structures of the new compounds were confirmed by FTIR and GCMS. All the data will be presented. Conclusions: Microwave assisted synthesis of the proposed compounds improved the obtained yield. FTIR confirmed the formation of new products and the disappearance of the starting materials while the GCMS confirmed the molecular weight of the obtained products. More compounds will be prepared and evaluated for their MAO inhibitory activity.