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Qatar Foundation Annual Research Conference Proceedings Volume 2014 Issue 1
- Conference date: 18-19 Nov 2014
- Location: Qatar National Convention Center (QNCC), Doha, Qatar
- Volume number: 2014
- Published: 18 November 2014
181 - 200 of 480 results
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The Kielin/chordin-like Protein Kcp Can Attenuate High Fat Diet Induced Obesity And Metabolic Syndrome In Mice Model
By Abdul SoofiObesity and its associated complications, such as insulin resistance and non-alcoholic fatty liver disease, are reaching epidemic proportions in the developed world, primarily due to the increased availability of high caloric foods and the decrease in daily physical activity. It is well established that energy balance is critical for maintaining normal body weight and homeostasis. When caloric intake chronically exceeds energy expendi Read More
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12/15-lipoxygenase: A Novel Therapeutic Target In Diabetic Retinopathy
Authors: Mohamed Al-shabrawey, Ahmed Ibrahim, Amany Tawfik, Sally Elshafey and Nasser RizkBackground: Breakdown of blood-retinal barrier (BRB) and subsequent hyperpermeability is a cardinal feature of early diabetic retinopathy (DR) and leading cause of blindness. Fatty acid metabolism is implicated in several biological functions via multiple signaling pathways including the synthesis of bioactive metabolites. Our previous studies established 12/15-lipoxygenase (12/15-LOX)-derived 12- and 15- hydroxyeicosat Read More
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In-vitro Cytotoxicity Of Selected Sudanese Medicinal Plants With Potential Antitumor Activity
Authors: Yasmin Hilmi and Muna Abushama1.Introduction: According to unique position and varied climate, terrain, and flora and fauna, the Sudanese have developed a unique traditional culture. Their unique indigenous knowledge of herbs led to the development of numerous general health and preventative remedies. Some are useful and some, although widely accepted due to custom and tradition, proved harmful. Identification of medicinal plants with significa Read More
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Involvement Of Intracellular Calcium [ca2+]i In The Treatment Of Human Neuroblastoma With Cisplatin (cddp) And Topotecan (topo)
Authors: Elizabeth Varghese, Ana-maria Florea, Guido Reifenberger and Dietrich BusselbergNeuroblastoma is a solid malignant embryonic tumor. It is usually diagnosed in the infancy and rarely found after the age of 10 years. In the current treatment options, CDDP and TOPO are included. Methods: Neuroblastoma (SH SY-5Y) cell death was investigated after treatment with CDDP and TOPO (0.1nM-1μM) using Trypan Blue Cytotoxicity Test and Total Cytotoxicity and Apoptosis Detection Kit (FACS). These data a Read More
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Store Operated Calcium Entry Controls Intracellular Calcium Waves In Xenopus Oocytes
Authors: Raphael Courjaret and Khaled MachacaIn many non-excitable cells such as glial cells, oocytes or beta-cells, fast transmission and integration of information are encoded in the variations of the intracellular Ca2+ concentration. These variations range from a single calcium peak (wave) to a repetitive pattern (oscillations). Intracellular Ca2+ oscillations are made of highly spatially and timely controlled cytoplasmic waves of Ca2+ fueled by two main Ca2+ sources: the e Read More
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Biocompatible Graphene Oxide With Anchored Zwitterionic Moiety - Synthesis, Characterization And Application
Authors: Marketa Ilcikova, Zuzana Kronekova, Anna Zahoranova and Peter KasakBiocompatible Graphene Oxide with Anchored Zwitterionic Moiety - Synthesis, Characterization and Application Markéta Ilčíková1, Zuzana Kroneková2, Anna Záhoranová2 and Peter Kasák1* 1 Center for Advanced Materials, Qatar University, P.O.Box 2713 Doha, Qatar 2 Polymer Institute, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava, Slovakia *Corresponding author: peter.kasak@qu.edu.qa The nove Read More
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Metastatic Cancer And Rna Editing: Brief Look At How Rna Editing Is Seen To Encourage Primary Cancer Cells To Metastasize
Authors: Lisa Mathew, Binu George, Iman Al Azwani, Eman Al Dous, Yasmin A Mohamoud, Arash Rafii and Joel A MalekObjective: Information that is present in our DNA is transferred to RNA, which is in turn transcribed into proteins. This is a central principle of molecular biology. Over the years, there have been many attempts to document the thousands of places where transcribed RNA does not match the DNA template it was created from. This behavior is called RNA Editing, and is generally thought to be mainly an A->I change, that is, Read More
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Remodeling Of Collagen-Fibers In Deformed Tissues
Authors: Heiko Topol, Hasan Demirkoparan, Thomas J. Pence and Alan WinemanOne goal in the field of soft tissue biomechanics is to understand and to model the properties of collagen-fibers in biological tissues such as blood vessels, brain tissues, and skin which undergo growth and remodeling processes. Experimental studies of Bhole et al.\ [1] suggest that the mechanical properties of fibers in biological tissues depend not only on the current state of the deformation but also on the deformation Read More
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Quantitative Microbial Risk Assessment For Campylobacter Jejuni And C. Coli Associated With The Consumption Of Camel Milk Qatar
Authors: Hussni Omar Mohammed, Kenlyn Peters, Ahmed Salem, Sanjay Doiphode and Ali SultanBackground and Introduction—According to the Food and Agricultural Organization that more than one-third of the population of the world is affected each year by food-borne diseases caused by chemical and biological hazards. Foodsafety has been identified as high priority in the Qatar National Food Security Master Plan. Campylobacter spp. are among the leading causes of foodborne illness and capable of triggering se Read More
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Docosahexaenoic Acid (DHA) Remedies Hyperglycemia-Induced Retinal Endothelial Dysfunction: A Potential Therapeutic Intervention For Diabetic Retinopathy
Authors: Nasser Rizk, Isha Sharma, Amina Fadel and Mohamed Al-shabraweyDiabetic retinopathy (DR) is a leading cause of blindness among working diabetic patients worldwide. The current therapeutic strategies are limited by several side effects. Thus, it is important to investigate novel approaches for therapeutic intervention. Early inflammatory response and late neovascularization (NV) are cardinal clinical signs of the DR. We have previously demonstrated the involvement of bioactive lipids especi Read More
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Bicuspid Aortic Valve In Qatar
Authors: Cornelia S Carr, Nizar Mohammed, Shady Mohammed, Madgi Yacoub, Sherif Helmy and Abdulaziz AlkhulaifiBicuspid Aortic Valve in Qatar N Mohammed, S Mohammed, M Yacoub, S Helmy, CS Carr, AM Alkhulaifi Objective Bicuspid Aortic Valve (BAV) is the commonest congenital cardiac anomaly with about 1% of the population being affected and can be divided into different phenotypes. The majority of BAV patients will require valve replacement surgery in their lifetime. We aimed to assess the BAV patients in Qatar in terms of demog Read More
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Measuring The Return On Investment For Research At Sidra
Authors: Zeina Jamaleddine and Stefano BertuzziGeneral consensus exists that biomedical research is a key determinant of innovation, health, and economic wellbeing. However, the answer to the question how do we determine and quantify the value and the impact of research is apparently simple, while a thoughtful and analytical answer quickly becomes very probing and difficult to address. Qatar has dedicated itself to transitioning from a resource-based to a knowledge- Read More
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Influence Of Qatar Agricultural Products On Human Cell Redox Homeostasis
Authors: Afnan Al-menhali, Safya Ali Jameela, Aishah A Latiff and Morana JaganjacReactive oxygen species (ROS) are generated ubiquitously by all mammalian cells and at small concentrations they act as physiological mediators of cellular response to various stimuli. Excessive ROS damages DNA, RNA, proteins and lipids triggering various diseases. Cellular redox homeostasis is thus, balanced by endogenous and exogenous antioxidant defense systems. Natural antioxidants have made a significant Read More
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Updated Lagrange Formulation Of Internally Balanced Compressible Hyperelastic Materials
Authors: Ashraf Hadoush, Hasan Demirkoparan and Tom J. PenceNonlinear continuum mechanics is commonly used to study the response of highly de- formable materials. Nowadays, the proposed material models often include internal ma- terial variables in order to capture realistic engineering behavior. The theoretical back- ground is mature and its implementation in the frame of nite element method is well established. Solely, these material constitutive models are expressed in ter Read More
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Antibacterial Modification Of Polyethylene By Multistage Process Utilizing Low-temperature Plasma
Authors: Anton Popelka, Igor Novák, Marián Lehocký and Igor KrupaLimiting factor of PE application in healthcare is high susceptibility of polyethylene towards bacterial growth. For this reason, antibacterial treatment of PE foils using appropriate antibacterial agents was used in this work. Benzalkonium chloride and bronopol were selected due to their satisfactory antibacterial effect confirmed by applications in medical and cosmetic industry. These antibacterial agents were immobilized onto PE sur Read More
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Non-coding RNA Biomarkers Of Diabetes And Metabolic Health
More LessBackground Islet cell death is a common feature of type 1 diabetes (T1D), including after islet cell transplantation, as well as of type 2 diabetes (T2D). As of today, we lack tools to quantitatively detect islet cell loss prior to the clinical onset of diabetes, or to predict the progression of established diabetes. Our preliminary data demonstrates that a signature of 20 different non-coding (nc) RNAs (including microRNAs) ref Read More
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RNA -seq Study Of Muscle And Adipose Tissue In Cancer Patients With Early Cachexia
Authors: Iman Al-azwani, Amal Al Haddad, Yasmin Mohamoud, Farouk Safi, Haytham Salhat, Joel Malek and Thomas AdrianObjectives: Cancer cachexia is a syndrome characterized by weight loss resulting from a reduction of lean body mass and adipose mass. Although often associated with pre-terminal patients bearing disseminated disease, cachexia may be present in the early stages of tumor growth before any signs or symptoms of malignancy. Studies show that weight loss in cachexia is not caused by malnutrition or starvation but, rather, by inf Read More
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Molecular Characterization Of White And Brown Adipocytes Reveals Complex Phenotypes
Over the last two decades the prevalence of obesity has reached epidemic levels worldwide. Secondary major health risks, such as hypertension, insulin resistance, type 2 diabetes and cardiovascular diseases, can be summarized as the metabolic syndrome and are highly associated with obesity. In cases in which energy intake e.g. through high caloric food intake exceeds energy expenditure the overall energy homeostasi Read More
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Arabic Symbol Dictionary For Augmentative And Alternative Communication (AAC) Users
Authors: Amal Idris Ahmad, Amatullah Kadous, Ea Draffan and Mike WaldThe Arabic Symbol Dictionary research project aims to develop a lexicon with symbols that are culturally appropriate for Qataris and the Arab world. This project focuses on symbol use for those who cannot communicate verbally such as those with Autism, Cerebral Palsy, Intellectual Disability and Aphasia. Symbols can be used to communicate wants and needs, provide a method for dialogue with others as well as acti Read More
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Identifying Novel Mutations In Familial Myeloproliferative Neoplasms Patients In The State Of Qatar Via Targeted Exome Sequencing Approach
Background: Polycythemia Vera (PV), Essential Thrombocytosis (ET) & Primary Myelofibrosis (PMF) are Philadelphia negative Myeloproliferative Neoplasms (MPNs) characterized by overproduction of one or more myeloid cell lineages. MPNs are associated with the presence JAK2 V617F mutation in 95% of PV & 50% of ET & PMF patients. Several molecular methods such as RQ-PCR, HRM & Sequencing are currently used t Read More
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