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Qatar Foundation Annual Research Conference Proceedings Volume 2016 Issue 1
- Conference date: 22-23 Mar 2016
- Location: Qatar National Convention Center (QNCC), Doha, Qatar
- Volume number: 2016
- Published: 21 March 2016
401 - 420 of 656 results
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Heme Oxygenase (HO)-1 Induction Prevents Endoplasmic Reticulum Stress-Mediated Endothelial Cell Death and Dysfunction
Authors: Abdelali Agouni, Hatem Maamoun, Matshediso Zachariah and Fiona GreenDiabetes is intimately associated with cardiovascular complications. Much evidence highlighted the complex interplay between Endoplasmic Reticulum (ER) stress and oxidative stress in the pathogenesis of diabetes. Hemeoxygenase-1 (HO-1) induction was shown to protect against oxidative stress in diabetes; however the underlying molecular mechanisms have not yet been fully elucidated. We aim in this project to Read More
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High Selenium Intake is Associated with Endothelial Dysfunction: Critical Role for Endoplasmic Reticulum Stress
Authors: Abdelali Agouni, Matshediso Zachariah, Hatem Maamoun and Margaret RaymanSelenium is associated with insulin resistance and may therefore affect endothelial function, increasing type II diabetes risk and associated cardiovascular-disease risk. However the underpinning molecular mechanisms involved are not clear. High selenium doses cause apoptosis in some cancer cells through the induction of endoplasmic reticulum (ER) stress response, a mechanism also involved in the pathogenesis of insu Read More
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Implementation of a New Genetic Screening Test for of Genetic Recessive Diseases in a Program of Oocyte Donation
Background Current screening for carriers of genetic diseases in oocyte donors includes the assessment of risk of transmission of inherited diseases based on personal and family history of genetic disorders. Most assisted reproduction centers also include karyotyping, mutational screening of the CFTR gene and directed the study of fragile X premutation. Next generation sequencing (NGS) technologies of have allo Read More
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Computer-Aided Design and Synthesis of N-aryl and Heteroarylpiperazine Derivatives as Dual Serotonergic Antagonists for Autism Treatment
Authors: Raed Shalaby, Ola Ghoneim and Ashraf KhalilBackground and Objective Autism Spectrum Disorders (ASD) are characterized by abnormalities in social interaction and communication skills, in addition to stereotypic behaviors and restricted activities and interests. Autism prevalence has dramatically increased from 1 case per 5000 children in the early 1980’s to1 case per 68 children as of 2015. A recent pilot study on the demographic distribution of children with aut Read More
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Antifolate Drug Resistance: Novel Mutations and Therapeutic Efficacy Study from Arunachal Pradesh, NE India
Malaria is a major public health concern in north east India with the preponderance of drug resistance strains. Till recently partner drug for Artemisinin Combination Therapy was Sulphadoxine Pyrimethamine. The antifolate drug resistance has been associated with the mutations at dihydropteroate synthase (dhps) and dihydrofolatereductase (dhfr) gene. The study was aimed to investigate the antifolate drug resista Read More
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Medication Risks Communication in Middle East Cancer Patients
Authors: Kerry Wilbur, Sumaya Al Saadi, Maha Al Okka, Ebaa Jumat, Alya Babiker, Marwa Al Bashir and Nesma EissaBackground Cancer treatments are frequently associated with adverse effects, but there may be a cultural reluctance by care providers to be forthcoming with patients regarding these risks for fear of promoting non-adherence. Conversely, research in a number of countries indicates high levels of patient desire for this information. We sought to pharmacist and nurse views and experiences in educating patients regarding t Read More
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Diabetes Mellitus: Unwanted Visitor in the Tertiary Heart Hospitals
Authors: Ayman El-Menyar, Jassim Al Suwaidi, Hajar Albinali and Hassan Al-ThaniDiabetes mellitus (DM) and cardiovascular diseases (CVD) constitute a major health care challenge worldwide. We evaluated the trends and outcome of DM in patients presenting with CVD over a 22-year period in the state of Qatar. Methods We performed a descriptive retrospective chart review of all admitted CVD patients, including DM from the Cardiology and Cardiovascular Surgery database at the Heart Hospital Read More
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MiSeq-Next Generation Sequencing Approach in Investigating the Evolutionary Dynamics of Viral Infection in Children with Type I Diabetes
More LessBackground There is no longer a question as to whether viruses contribute to the pathogenesis of type 1 diabetes (T1D), as we recently reviewed, but rather how they contribute and, in particular, the role of viral diversity and evolution in the disease process. The recent finding of enterovirus (EV) capsid protein VP1 in pancreatic autopsy samples from the JDRF Network for Pancreatic Organ Donors with Diabetes (nPOD) suppor Read More
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On the way to the Optimal Design of an Aortic Heart Valve -or- Discovering the Obvious?
Authors: Albert Ryszard Liberski and Radoslaw KotThe first task of tissue engineer trying to make a scaffold of a heart valve, is to adapt some model of a heart valve to establish target geometries and properties that should be recreated in artificial scaffold. The natural way to do so is to conduct literature research and find the current scientific consensus on the topic. Here the problems start, each researcher seems to have an individual opinion about optimal geometry Read More
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Social Hypertension Awareness System in Gulf Countries (SHAMS)
Authors: Mohammed Alotaibi and Zaid BassfarHypertension prevalence around the world has risen over the last few years. The gulf countries has become one of the most affected countries in the world. Saudi Arabia only estimated that 24% of the current population is suffering from hypertension. This has been attributed to elements such as lack of proper management systems for hypertension and inadequate education systems in the region. In addition to this health prob Read More
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Prevalence and Associated Factors of Physical Activity Among Mothers in the Gaza Strip-Palestine
Authors: Rima El Kishawi, Kah Leng Soo, Yehia Abed and Wan Abdul Manan Wan MudaBackground The high prevalence of obesity was observed in numerous developed and developing countries. A reduce in energy expenditure due to the low physical activity level is a factor contributed to the increase in obesity. Physical inactivity is one of the ten leading risk factors for global death, and associated with the all-cause mortality. Regular physical activity lowers the risk of various types of non-communicable diseas Read More
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Designing Customized Peptide-Linkers to Functionalize Scaffolds and Nanoparticles for Tissue Engineering Applications
Authors: Navaneethakrishnan Krishnamoorthy, Yuan-Tsan Tseng and Magdi YacoubIntroduction and Objectives Engineering living tissues or organs critically depends on the use of scaffolds to attract, house and instruct host cells. To achieve this, the scaffolds need to be functionalised using different strategies. One of these strategies relies on the use designer peptides to decorate scaffolds. Peptide linkers have shown increasing importance in the production of bioactive materials for various biological appli Read More
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A Prospective Study Regarding Factors Related to Unscheduled Revisit Within 72 Hours in Adult Emergency Department. Al Khor Hospital, State of Qatar
Background Crowding in hospital Emergency Departments (EDs) is a commonly observed problem in all over the world. Although the reasons and mechanisms are different, the major factors are increasing volume of patients seeking medical care in ED services, lack of inpatient beds, and care for non-urgent conditions for patients who identify the ED as their easiest and usual site of care, notwithstanding the typical treatment o Read More
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Development of an Automated, Real-Time Health Monitor and Emergency Alert System for the Elderly
Authors: Francis Enejo Idachaba and Ejura Mercy IdachabaThe state of health of the elderly members of society and the fact that most of this group of persons either live alone or with family creates a need for constant monitoring as they are often times left alone for the greater part of the day when their hosts or family members have to go to work. The most common cause of death among the aged is heart related. Heath related medical emergencies range from heart attacks to str Read More
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Epidemiological And Clinical Feature of Newly Diagnosed Childhood Immune Thrombocytopenic Purpura in Qatar
Background ITP (Immune thrombocytopenic purpura) is the most common bleeding disorder in childhood. It is usually a self-limiting disorder, and most patients recover spontaneously without serious complication. The clinical features of ITP have remained unchanged over the past few decades but there have been many recent changes in management strategies as evidenced by the new international guidelines on the Read More
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Factors to Increase Influenza Vaccination Acceptence and Coverage Rate Among Pediatricians
Background Influenza is a highly infectious but preventable viral illness. Influenza vaccine remain the cornerstone of prevention, WHO encourages annual influenza vaccinations for all children and youth ≥ 6 months of age and those who have chronic illness at risk for the development of complications. Vaccinating pediatricians will reduce their risk of getting the flu and could potentially prevent illness in patients; their posit Read More
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Protein Engineering of Glucarpidase to Improve Cancer Therapy Strategies
Authors: Sayed K Goda, Alanod Alqahtani, Mathew Groves and Alex DomlingAntibody Directed Enzyme Prodrug Therapy (ADEPT) is a technique used in cancer treatment, which convert a prodrug to a powerful cytotoxic drug only in the vicinity of the tumor. The technique relies on a bacterial enzyme, glucarpidase (former name: carboxypeptidase G2, CPG2). Also the glucarpidase is a very effective enzyme for detoxification of methotrexate, (MTX) which serves as an important component of various c Read More
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Mast Cell Proteases as Key Clinical Markers and New Targets for Drug Development in Allergic Disease: Implications for Anti-Doping Policy
Authors: Sayed K Goda, Afrah Al-Yafei, Haya Al Sulaiti, Araf Kyyaly, Mohammed Alsayrafi and Andrew WallsThere have been dramatic increases in the prevalence of allergic conditions throughout the world. Until recently conditions such as allergic asthma and rhinitis, and life-threatening anaphylaxis were relatively rare in Qatar and the Gulf states, but the proportion of the population affected now seem to be approaching the high levels of many Western countries. There is a pressing need for better means for effective diagnosis, fo Read More
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Building of a Large Scale De-Identified Biomedical Database in Qatar-Principles and Challenges
Authors: Fida K. Dankar and Rashid Al-AliBackground Electronic Medical Records (EMRs) hold diverse clinical information about large populations. When this information is coupled with genetic data, it has the potential to make unprecedented associations between genes and diseases. The incorporation of these discoveries into healthcare practice offers the hope to improve healthcare through personalized treatments. The Qatar National Genome project aims t Read More
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A Genome Wide Association Search for Type 2 Diabetes Genes in Arabic Populations
Authors: Mohamed Chikri, Younes Elachhab, Loic Yengo, Audry Leloire, Martine Vaxilaire and Philippe FroguelType 2 diabetes (T2D) is a chronic condition that emerged as serious medical, social and economic problem worldwide. Qatar was ranked by the IDF among the top 10 countries in the world with the highest prevalence of T2D that exceeds 20%. The causes of T2D are multiple but the contribution of genetic is well recognized. So far, large-scale genome-wide association studies (GWAS) have identified more than 80 sus Read More
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