-
oa Synthesis and stereochemistry of 6-membered ring phosphonates
- Source: QScience Connect, Volume 2012, Issue 1, يناير ٢٠١٢, 2
-
- ٢٣ ديسمبر ٢٠١١
- ٢٧ فبراير ٢٠١٢
- ٠٥ مارس ٢٠١٢
ملخص
Abstract
Background: Organophosphorus compounds have important industrial and biomedical applications as pharmaceutical and agrochemical agents, as well as transition state analogs for the production of monoclonal antibodies.
Methods: Two diastereomers of a 6-membered ring, cyclic phenyl phosphonate were synthesized in 8 steps from 1,3-butanediol.
Results: The stereochemistry of the diastereomers was elucidated on the basis of 31P NMR signals, together with 1H NMR nuclear Overhauser effects (NOE) difference experiments.
Conclusions: Such cyclic phosphonates may have utility serving as transition state analogs for the production of monoclonal antibodies.
© 2012 Pungente and Weiler, licensee Bloomsbury Qatar
Foundation Journals.