1887
  1. الرئيسية
  2. A-Z Publications
  3. Global Cardiology Science and Practice
  4. المجلد 2013, العدد 4
  5. المقالة
Volume 2013, Issue 4
  • ISSN: 2305-7823
  • E-ISSN:

ملخص

The recent increase in human lifespan, coupled with unhealthy diets and lifestyles have led to an unprecedented increase in cardiovascular diseases. Even in the presence of a wide range of therapeutic options with variable efficacy, mortality due to heart failure is still high and there is a need to identify new therapeutic targets. Genetic and studies have implicated the Notch signalling in the development and maintenance of the cardiovascular system through a direct effect on biological functions of vascular cells (endothelial and vascular smooth muscle cells) and cardiomyocytes. Notch signalling is also involved in the modulation of inflammation, which plays a major role in causing and exacerbating cardiovascular diseases. The Notch pathway could represent a new therapeutic target for the treatment of cardiovascular diseases.

© 2013 Aquila, Pannella, Morelli, Caliceti, Fortini, Rizzo, Ferrari, licensee Bloomsbury Qatar Foundation Journals.
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The role of Notch pathway in cardiovascular diseases
Global Cardiology Science and Practice 2013, 44 (٢٠١٤); https://doi.org/10.5339/gcsp.2013.44
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Supplementary File 1

  • نوع المستند: Review Article
الموضوعات الرئيسية apoptosis, atherosclerosis, cardiomyocytes, cardiotoxicity, endothelial cells and heart failure
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