1887
  1. الرئيسية
  2. A-Z Publications
  3. Global Cardiology Science and Practice
  4. المجلد 2015, العدد 4
  5. المقالة
Volume 2015, Issue 4
  • ISSN: 2305-7823
  • E-ISSN:

ملخص

Human genetic discoveries offer a powerful method to implicate pathways of major importance to disease pathobiology and hence provide targets for pharmacological intervention. The genetics of pulmonary arterial hypertension (PAH) strongly implicates loss-of-function of the bone morphogenetic protein type II receptor (BMPR-II) signalling pathway and moreover implicates the endothelial cell as a central cell type involved in disease initiation. We and others have described several approaches to restore BMPR-II function in genetic and non-genetic forms of PAH. Of these, supplementation of endothelial BMP9/10 signalling with exogenous recombinant ligand has been shown to hold considerable promise as a novel large molecule biopharmaceutical therapy. Here, we describe the mechanism of action and discuss potential additional effects of BMP ligand therapy.

© 2015 Ormiston, Upton, Li, Morrell, licensee Bloomsbury Qatar Foundation Journals.
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/content/journals/10.5339/gcsp.2015.47
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The promise of recombinant BMP ligands and other approaches targeting BMPR-II in the treatment of pulmonary arterial hypertension
Global Cardiology Science and Practice 2015, 47 (٢٠١٥); https://doi.org/10.5339/gcsp.2015.47
/content/journals/10.5339/gcsp.2015.47
/content/journals/10.5339/gcsp.2015.47
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