Oral manifestations and hemoglobin level in children with subclinical hypothyroidism

Hayder Mahdi Idan; Saif Hakeem Tofiq

doi:10.5339/jemtac.2024.midc.13

8 - The 3rd Mustansiriyah International Dental Conference

ISSN: 1999-7086
E-ISSN: 1999-7094

oa Oral manifestations and hemoglobin level in children with subclinical hypothyroidism
المؤلفون: Hayder Mahdi Idan¹ and Saif Hakeem Tofiq²
عرض الانتماءات إخفاء الانتسابات المهنية

االانتسابات المهنيه ¹ Department of Clinical Dental sciences, College of Dentistry, University of Diyala, Diyala, Iraq ² Department of Pediatrics, College of Medicine, University of Diyala, Diyala, Iraq

*Correspondence: Hayder Mahdi Idan [email protected]
Source: Journal of Emergency Medicine, Trauma and Acute Care, Volume 2024, Issue 8 - The 3rd Mustansiriyah International Dental Conference, ديسمبر ٢٠٢٤, 13
DOI https://doi.org/10.5339/jemtac.2024.midc.13
- المستلَم: ٢٠ مايو ٢٠٢٤
- المقبول: ٠٢ يونيو ٢٠٢٤
- تاريخ النشر الكترونيا: ٠٩ ديسمبر ٢٠٢٤

ملخص

Background: Subclinical hypothyroidism (SH), or so-called mild thyroid failure, is analyzed when serum thyroid stimulating hormone (TSH) levels are beyond the highest limit of the reference range whereas free T4 concentrations are normal.

Aim of the Study: Determine delayed tooth eruption and hemoglobin levels in children with SH.

Methods: Case control study was directed amongst 120 children with age not exceed than 12 years old in Diyala governorate. Thyroid function, hemoglobin level, and a common oral manifestation in children with SH were evaluated to find an association between them and compared with healthy children. Children who have SH, after experiencing thyroid tests, have their mouths examined and their hemoglobin levels inspected; after receiving ethical clearance, informed consent was obtained from the relatives of participants.

Results: Concerning patients (first group), which is comprised of 100 children with SH, control (second group) comprises of 20 children without SH. The delayed eruption of teeth was (7%) in SH children statistically showed a highly significant association. Level of TSH in the children with SH group was statistically highly significant increased as compared with the control group with Mean ± SE (8.93 ± 0.32) versus Mean ± SE (1.84 ± 0.25). In addition, a highly significant association existed when compared the control group and children with SH concerning hemoglobin level, with Mean ± SE (13.09 ± 0.14) versus Mean ± SE (10.89 ± 0.19).

Conclusion: Low level of hemoglobin and high prevalence of delayed tooth eruption were detected in children with SH compared to non-diseased control group.

جارٍ تحميل قياسات المقالة...

/content/journals/10.5339/jemtac.2024.midc.13

٢٠٢٤-١٢-٠٩

٢٠٢٥-٠١-٠٢

Full text loading...

/deliver/fulltext/jemtac/2024/8/jemtac.2024.midc.13.html?itemId=/content/journals/10.5339/jemtac.2024.midc.13&mimeType=html&fmt=ahah

References

Pinto A, Glick M. Management of Patients with Thyroid Disease: Oral Health Considerations. J Am Dent Assoc. 2002; 133:849–58. https://doi.org/10.14219/jada.archive.2002.0299
[Google الباحث العلمي]
Achanta A, Khasbage SD. Oral Manifestations of Thyroid Disorders. J Res Med Dent Sci. 2022; 10:(9):12–6.
[Google الباحث العلمي]
Crisafulli G, Aversa T, Zirilli G, Pajno GB, Corica D, De Luca F, et al. Subclinical Hypothyroidism in Children: When a Replacement Hormonal Treatment Might be Advisable. Front Endocrinol (Lausanne). 2019; 10:109. https://doi.org/10.3389/fendo.2019.00109
[Google الباحث العلمي]
Van Deventer HE, Mendu DR, Remaley AT, Soldin SJ. Inverse Log-Linear Relationship between Thyroid-Stimulating Hormone and Free Thyroxine Measured by Direct Analog Immunoassay and Tandem Mass Spectrometry. Clin Chem. 2011; 57:122–7. https://doi.org/10.1373/clinchem.2010.154088
[Google الباحث العلمي]
Biondi B, Cappola AR, Cooper DS. Subclinical Hypothyroi Dism: A Review. JAMA. 2019; 322:153–60. https://doi.org/10.1001/jama.2019.9052
[Google الباحث العلمي]
Léger J, Olivieri A, Donaldson M, Torresani T, Krude H, van Vliet G, et al. European Society for Paediatric Endocrinology Consensus Guidelines on Screening, Diagnosis, and Management of Congenital Hypothyroidism. J Clin Endocrinol Metab. 2014; 99:(2):363–84. https://doi.org/10.1210/jc.2013-1891
[Google الباحث العلمي]
Salerno M, Capalbo D, Cerbone M, De Luca F. Subclinical Hypothyroidism in Childhood—Current Knowledge and Open Issues. Nat Rev Endocrinol. 2016; 12:(12):734–46. https://doi.org/10.1038/nrendo.2016.100
[Google الباحث العلمي]
Karmisholt J, Andersen S, Laurberg P. Variation in Thyroid Function in Subclinical Hypothyroidism: Importance of Clinical Follow-up and Therapy. Eur J Endocrinol. 2011; 164:(3):317–23. https://doi.org/10.1530/EJE-10-1021
[Google الباحث العلمي]
Clerico A, Ripoli A, Fortunato A, Alfano A, Carrozza C, Correale M, et al. Harmonization Protocols for TSH Immunoassays: A Multicenter Study in Italy. Clin Chem Lab Med. 2017; 55:(11):1722–33. https://doi.org/10.1515/cclm-2016-0899
[Google الباحث العلمي]
da SilvaVA, de Almeida RJ, Cavalcante MP, Pereira Junior LA, Reis FM, Pereira MF, et al. Two Thyroid Stimulating Hormone Assays Correlated in Clinical Practice Show Disagreement in Subclinical Hypothyroidism Patients. Clin Biochem. 2018; 53:13–8. https://doi.org/10.1016/j.clinbiochem.2017.12.005
[Google الباحث العلمي]
SAS. Statistical Analysis System, User’s Guide Statistical Version. 9.6th ed. Cary. N.C. USASAS. Inst. Inc; 2018.
[Google الباحث العلمي]
Khatiwada S, Gelal B, Baral N, Lamsal M. Association Between Iron Status and Thyroid Function in Nepalese Children. BioMed Cent Thyroid Res. 2016; 9:2. https://doi.org/10.1186/s13044-016-0031-0
[Google الباحث العلمي]
Zimmermann MB, Hurrell RF. Nutritional Iron Deficiency. Lancet. 2007; 370:511–20. https://doi.org/10.1016/S0140-6736(07)61235-5
[Google الباحث العلمي]
Gökdeniz E, Demir C, Dilek I. The Effects of Iron Deficiency Anemia on the Thyroid Functions. J Clin Exp Invest. 2010; 1:156–60. https://doi.org/10.5799/ahinjs.01.2010.03.0033
[Google الباحث العلمي]
Metwalley KA, Farghaly HS, Hassan AF. Thyroid Status in Egyptian Primary School Children with Iron Deficiency Anemia: Relationship to Intellectual Function. Thyroid Res Pract. 2013; 10:91–5. https://doi.org/10.4103/0973-0354.116131
[Google الباحث العلمي]
Refaat B. Prevalence and Characteristics of Anemia Associated with Thyroid Disorders in Non-Pregnant Saudi Women During the Childbearing Age: A Cross-Sectional Study. Biomed J. 2015; 38:(4):307–16. https://doi.org/10.4103/2319-4170.151032
[Google الباحث العلمي]
Kammal M, Abdrabo AA. Assessment of Thyroid Hormone Levels in Sudanese Females with Iron Deficiency. Sudan Med J. 2014; 50:(2):98–102. https://doi.org/10.12816/0015580
[Google الباحث العلمي]
Akhter S, Naher ZU, Parvin S, Nahar K, Ali M, Bashar T, et al. The Status of Thyroid Hormones in Iron Deficient Patients in Bangladesh. Med Today. 2012; 24:(1):1–4. https://doi.org/10.3329/medtoday.v24i1.13941
[Google الباحث العلمي]
Eftekhari MH, Keshavarz SA, Jalali M, Elguero E, Eshraghian MR, Simondon KB. The Relationship Between Iron Status and Thyroid Hormone Concentration in Iron-Deficient Adolescent Iranian Girls. Asia Pac J Clin Nutr. 2006; 15:(1):50–5.
[Google الباحث العلمي]
Hess SY, Zimmermann MB, Arnold M, Langhans W, Hurrell RF. Iron Deficiency Anemia Reduces Thyroid Peroxidase Activity in Rats. J Nutr. 2002; 132:(7):1951–5. https://doi.org/10.1093/jn/132.7.1951
[Google الباحث العلمي]
Hussien GG, Ali OH. Evaluation of Salivary Tumor Necrosis Factor-Alpha in Patients with Hypothyroidism and Periodontitis: A Case-Control Study. Mustansiria Dent J. 2023; 19:(1):92–106.
[Google الباحث العلمي]
Arlappa N, Laxmaiah A, Balakrishna N, Harikumar R, Kodavanti MR, Reddy CG, et al. Micronutrient Deficiency Disorders Among the Rural Children of West Bengal, India. Ann Hum Biol. 2011; 38:(3):281–9. https://doi.org/10.3109/03014460.2010.536572
[Google الباحث العلمي]
Eftekhari MH, Eshraghian MR, Mozaffari-Khosravi H, Saadat N, Shidfar F. Effect of Iron Repletion and Correction of Iron Deficiency on Thyroid Function in Iron-Deficient Iranian Adolescent Girls. Pak J Biol Sci. 2007; 10:(2):255–60. https://doi.org/10.3923/pjbs.2007.255.260
[Google الباحث العلمي]

/content/journals/10.5339/jemtac.2024.midc.13

Oral manifestations and hemoglobin level in children with subclinical hypothyroidism

Journal of Emergency Medicine, Trauma and Acute Care 2024, 13 (٢٠٢٤); https://doi.org/10.5339/jemtac.2024.midc.13

/content/journals/10.5339/jemtac.2024.midc.13

جارٍ تحميل البيانات والوسائط...

الموضوعات الرئيسية hemoglobin, hypothyroidism, oral cavity and thyroid-stimulating hormone

الأكثر اقتباسًا لهذا الشهر Most Cited RSS feed

- Evolution of emergency medical services in Saudi Arabia
  
  المؤلفون: Talal AlShammari, Paul Jennings and Brett Williams
- Disaster medicine curricula in Saudi Arabian medical schools
  
  المؤلفون: Nidaa Bajow, Ahmadreza Djalali, Pier Luigi Ingrassia, Hussein Ageely, Ibrahim Bani and Francesco Della Corte
- In terms of the PCR-RFLP technique, genetic screening of Ala575Val inactivating mutation in patients with amenorrhea
  
  المؤلفون: Bushra A. Kanaan, Mushtak T.S. Al-Ouqaili and Rafal M. Murshed
- Association between alcohol consumption, cigarette smoking, and Helicobacter pylori infection in Iraqi patients submitted to gastrointestinal endoscopy
  
  المؤلفون: Rawaa A. Hussein, Mushtak T.S. Al-Ouqaili and Yasin H. Majeed
- Identifying a safe site for intercostal catheter insertion using the mid-arm point (MAP)
  
  المؤلفون: Fei Bing, Mark Fitzgerald, Alexander Olaussen, Pete Finnegan, Gerard O'Reilly, Rob Gocentas, Helen Stergiou, Anna Korin, Silvana Marasco and David McGiffin
- The history of emergency medical services response to mass casualty incidents in disasters, Saudi Arabia
  
  المؤلفون: Waleed Alazmy, Osama Samarkandi and Brett Williams
- Bilateral intratonsillar abscesses: A first case report in an adult patient
  
  المؤلفون: Jack Pein Cheong, Aun Wee Chong and Kein Seong Mun
- Attenuated effects of rivastigmine in induced cytokine storm in mice
  
  المؤلفون: Ahmed F. Abed Mansoor and Ahmed R. Abu Raghif
- Disconnect between available literature and clinical practice: Exploring gaps in the management of t-BPPV in the emergency department
  
  المؤلفون: Khalid Bashir, Sameer Pathan, Saleem Farook, Muhammad Masood Khalid and Sameh Zayed
- Prediction of critical haemorrhage following trauma: A narrative review
  
  المؤلفون: Alexander Olaussen, Prasanthan Thaveenthiran, Mark C. Fitzgerald, Paul A. Jennings, Jessica Hocking and Biswadev Mitra
مزيد أقل

oa Oral manifestations and hemoglobin level in children with subclinical hypothyroidism

ملخص

Most Read This Month

الأكثر اقتباسًا لهذا الشهر Most Cited RSS feed