1887
  1. الرئيسية
  2. A-Z Publications
  3. Journal of Emergency Medicine, Trauma and Acute Care
  4. المجلد 2024, العدد 8
  5. المقالة
8 - The 3rd Mustansiriyah International Dental Conference
  • ISSN: 1999-7086
  • E-ISSN: 1999-7094

ملخص

Temporomandibular disorder is a broad term for the joint musculoskeletal problems. This study was aimed to assess the therapeutic effect of hyaluronic acid (HA) and platelet-rich plasma (PRP) on salivary matrix metalloproteinases (MMPs) 2 and 9 expression in patients with internal derrangment.

Fifty-two patients with tempromandibular joint internal derrangment were participated in this study. Patients were separated into two groups: HA and PRP groups. Saliva was obtained before treatment and 6 months after treatment. The expression of MMP-2 and 9 was identified using enzyme-linked immunosorbent assay kit.

The expression of both salivary MMP-2 and 9 was significantly decreased after treatment (p = 0.000). A positive correlation was established between MMP-2 and 9 with the mean pain scale and joint click score. However, a negative correlation was found between MMP-2 and 9 with the maximum mouth opening (MMO).

Both HA and PRP showed a beneficial therapeutic effect revealed through the reduction of salivary MMP-2 and 9 as an inflammatory biomarkers.

© 2024 Thamer, Diajil, licensee HBKU Press.
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/content/journals/10.5339/jemtac.2024.midc.3
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Therapeutic effect of intra-articular injection of hyaluronic acid and platelet-rich plasma on the expression of salivary matrix metalloproteinases 2 and 9 in tempromandibular internal derrangment patients
Journal of Emergency Medicine, Trauma and Acute Care 2024, 3 (٢٠٢٤); https://doi.org/10.5339/jemtac.2024.midc.3
/content/journals/10.5339/jemtac.2024.midc.3
/content/journals/10.5339/jemtac.2024.midc.3
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الموضوعات الرئيسية hyaluronic acid, platelet-rich plasma, salivary matrix metalloproteinases and tempromandibular internal derrangment

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