1887
  1. Home
  2. A-Z Publications
  3. Journal of Emergency Medicine, Trauma and Acute Care
  4. Volume 2024, Issue 8
  5. Article
8 - The 3rd Mustansiriyah International Dental Conference
  • ISSN: 1999-7086
  • EISSN: 1999-7094

Abstract

Temporomandibular disorder is a broad term for the joint musculoskeletal problems. This study was aimed to assess the therapeutic effect of hyaluronic acid (HA) and platelet-rich plasma (PRP) on salivary matrix metalloproteinases (MMPs) 2 and 9 expression in patients with internal derrangment.

Fifty-two patients with tempromandibular joint internal derrangment were participated in this study. Patients were separated into two groups: HA and PRP groups. Saliva was obtained before treatment and 6 months after treatment. The expression of MMP-2 and 9 was identified using enzyme-linked immunosorbent assay kit.

The expression of both salivary MMP-2 and 9 was significantly decreased after treatment (p = 0.000). A positive correlation was established between MMP-2 and 9 with the mean pain scale and joint click score. However, a negative correlation was found between MMP-2 and 9 with the maximum mouth opening (MMO).

Both HA and PRP showed a beneficial therapeutic effect revealed through the reduction of salivary MMP-2 and 9 as an inflammatory biomarkers.

© 2024 Thamer, Diajil, licensee HBKU Press.
Loading

Article metrics loading...

/content/journals/10.5339/jemtac.2024.midc.3
2024-12-04
2024-12-21
Loading full text...

Full text loading...

/deliver/fulltext/jemtac/2024/8/jemtac.2024.midc.3.html?itemId=/content/journals/10.5339/jemtac.2024.midc.3&mimeType=html&fmt=ahah

References

  1. Christidis N, Al-Moraissi EA, Barjandi G, Svedenlöf J, Jasim H, Christidis M, et al. Pharmacological Treatments of Temporomandibular Disorders: A Systematic Review Including a Network Meta-Analysis. Drugs. 2024; 84:(1):59–81. https://doi.org/10.1007/s40265-023-01971-9
     [Google Scholar]
  2. Hassan TA, Suhail ZA. The Efficacy of Ozonized Water Versus Ringer Lactate Arthrocentesis for the Treatment of Temporomandibular Joint Internal Derangement. J Craniofac Surg. 2023; 34:(3):e238–e41. https://doi.org/10.1097/SCS.0000000000009085
     [Google Scholar]
  3. Macedo De Sousa B, López-Valverde N, López-Valverde A, Caramelo F, Flores Fraile J, Herrero Payo J, et al. Different Treatments in Patients with Temporomandibular Joint Disorders: A Comparative Randomized Study. Medicina. 2020; 56:(3):113. https://doi.org/10.3390/medicina56030113
     [Google Scholar]
  4. Adel A, Aswad F, Nusrath M. Digital and Clinical Evaluation of Temporomandibular Disorders in Full Dentition and Free End Extension Patients. Mustansiria Dent J. 2023; 19:(2):260–9. https://doi.org/10.32828/mdj.v19i2.890
     [Google Scholar]
  5. Salamah T, Harefa GN. Diagnostic Value and Clinical Significance of High-Resolution Ultrasonography Compared to Magnetic Resonance Imaging in Diagnosing Temporomandibular Joint Dislocation: A Systematic Review. Med J Indones. 2024; 33:(1):29–34. https://doi.org/10.13181/mji.oa.247184
     [Google Scholar]
  6. Hosgor H. Is Arthrocentesis Plus Hyaluronic Acid Superior to Arthrocentesis Alone in the Treatment of Disc Displacement Without Reduction in Patients with Bruxism? J Craniomaxillofac Surg. 2020; 48:(11):1023–7. https://doi.org/10.1016/j.jcms.2020.07.008
     [Google Scholar]
  7. Karadayi U, Gursoytrak B. Randomised Controlled Trial of Arthrocentesis With or Without PRF for Internal Derangement of the TMJ. J Craniomaxillofac Surg. 2021; 49:(5):362–7. https://doi.org/10.1016/j.jcms.2021.01.018
     [Google Scholar]
  8. Vingender S, Restár L, Csomó KB, Schmidt P, Hermann P, Vaszilkó M. Intra-articular Steroid and Hyaluronic Acid Treatment of Internal Derangement of the Temporomandibular Joint. Orv Hetil. 2018; 159:(36):1475–82. https://doi.org/10.1556/650.2018.31138
     [Google Scholar]
  9. Bahgat MM, EL-Helw NR, Abdelhamid AM, Fata MM, Ashour MS, Atteya A. Intra-Articular Regenerative Injection for Management of Painful Irreducible Temporomandibular Disc Displacement. Alexandria Dent J. 2024; 49:(2):158–163. https://doi.org/10.21608/adjalexu.2023.201880.1362
     [Google Scholar]
  10. Pifer MA, Maerz T, Baker KC, Anderson K. Matrix Metalloproteinase Content and Activity in Low-Platelet, low-Leukocyte and High-Platelet, High-Leukocyte Platelet Rich Plasma (PRP) and the Biologic Response to PRP by Human Ligament Fibroblasts. Am J Sports Med. 2014; 42:(5):1211–8. https://doi.org/10.1177/0363546514524710
     [Google Scholar]
  11. Almeida LE, Caporal K, Ambros V, Azevedo M, Noronha L, Leonardi R, et al. Immunohistochemical Expression of Matrix Metalloprotease-2 and Matrix Metalloprotease-9 in the Disks of Patients with Temporomandibular Joint Dysfunction. J Oral Pathol Med. 2015; 44:(1):75.9. https://doi.org/10.1111/jop.12213
     [Google Scholar]
  12. Ali VS, Aldaher ZA, Abdul-Kareem SH, Hassan HF, Shaker RM, Azeez RA. Estimation of Serum Matrix Metalloproteinases-1 Levels in Iraqi Female Patients with Osteoarthritis. Health Sci. 2018; 7:(5):18.22.
    [Google Scholar]
  13. Carla L, Veronica F, Almeida LE, La Rosa GRM, Rosalia L, Grippaudo C, et al. MMP-7 and MMP-9 are Overexpressed in the Synovial Tissue from Severe Temporomandibular Joint Dysfunction. Eur J Histochem. 2020; 2020:(64: 3113):8.12. https://doi.org/10.4081/ejh.2020.3113
     [Google Scholar]
  14. Ita ME, Ghimire P, Granquist EJ, Winkelstein BA. MMPs in Tissues Retrieved During Surgery from Patients with TMJ Disorders Relate to Pain More Than to Radiological Damage Score. J Orthop Res. 2022; 40:(2):338.47. https://doi.org/10.1002/jor.25048
     [Google Scholar]
  15. Park YM, Ahn Y-W, Jeong S-H, Ju H-M, Jeon H-M, Kim K-H, et al. Interleukin-8 and Matrix Metalloprotease 9 as Salivary Biomarkers of Pain in Patients with Temporomandibular Disorder Myalgia: A Pilot Study. J Oral Med Pain. 2019; 44:(4):160.8. https://doi.org/10.14476/jomp.2019.44.4.160
     [Google Scholar]
  16. Yaman D, Alpaslan C, Akca G, Avc. E. Correlation of Molecular Biomarker Concentrations Between Synovial Fluid and Saliva of the Patients with Temporomandibular Disorders. Clin Oral Invest. 2020; 24::4455-61. https://doi.org/10.1007/s00784-020-03310-8
     [Google Scholar]
  17. Schiffman E, Ohrbach R, Truelove E, Look J, Anderson G, Goulet JP, et al. Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: Recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Group†. J Oral Facial Pain Headache. 2014; 28:(1):6.27. https://doi.org/10.11607/jop.1151
     [Google Scholar]
  18. Pihut M, Gala A. The Application of Intra-Articulr Injections for Management of the Consequences of Disc Displacement Without Reduction. Int J Environ Res Pub Health. 2020; 17:(13):4726. https://doi.org/10.3390/ijerph17134726
     [Google Scholar]
  19. Kollarova M, Puzserova A, Balis P, Radosinska D, Tothova L, Bartekova M, et al. Age-and Phenotype-Dependent Changes in Circulating MMP-2 and MMP-9 Activities in Normotensive and Hypertensive Rats. Int J Mol Sci. 2020; 21:(19):7286. https://doi.org/10.3390/ijms21197286
     [Google Scholar]
  20. Baggio C, Boscaro C, Oliviero F, Trevisi L, Ramaschi G, Ramonda R, et al. Gender Differences and Pharmacological Regulation of Angiogenesis Induced by Synovial Fluids in Inflammatory Arthritis. Biomed Pharmacother. 2022; 152::113181. https://doi.org/10.1016/j.biopha.2022.113181
     [Google Scholar]
  21. Vingender S, D.ri F, Schmidt P, Hermann P, Vaszilko MT. Evaluation of the Efficiency of Hyaluronic Acid, PRP and I-PRF Intra-Articular Injections in the Treatment of Internal Derangement of the Temporomandibular Joint: A Prospective Study. J Craniomaxillofac Surg. 2023; 51:(1):1.6. https://doi.org/10.1016/j.jcms.2023.01.017
     [Google Scholar]
  22. Dalirsani Z, Pakfetrat A, Delavarian Z, Hashemy SI, Mostaan LV, Abdollahnejad M, et al. Comparison of Matrix Metalloproteinases 2 and 9 Levels in Saliva and Serum of Patients with Head and Neck Squamous Cell Carcinoma and Healthy Subjects. Int J Can Manag. 2019; 12:(5):e90249. https://doi.org/10.5812/ijcm.90249
     [Google Scholar]
  23. Attia AA, Awad SS. Hyaluronic Acid and Platelet-Rich Plasma Mixture Versus Hyaluronic Acid and Corticosteroid in the Treatment of Temporomandibular Joint Internal Derangement: A Comparative Randomized Study. J Maxillofac Oral Surg. 2023; 23:(2):1.7. https://doi.org/10.1007/s12663-023-01907-6
     [Google Scholar]
  24. Xu J, Ren H, Zhao S, Li Q, Li C, Bao G, et al. Comparative Effectiveness of Hyaluronic Acid, Platelet-Rich Plasma, and Platelet-Rich Fibrin in Treating Temporomandibular Disorders: A Systematic Review and Network Meta-Analysis. Head Face Med. 2023; 19:(1):39. https://doi.org/10.1186/s13005-023-00369-y
     [Google Scholar]
/content/journals/10.5339/jemtac.2024.midc.3
Loading
Therapeutic effect of intra-articular injection of hyaluronic acid and platelet-rich plasma on the expression of salivary matrix metalloproteinases 2 and 9 in tempromandibular internal derrangment patients
Journal of Emergency Medicine, Trauma and Acute Care 2024, 3 (2024); https://doi.org/10.5339/jemtac.2024.midc.3
/content/journals/10.5339/jemtac.2024.midc.3
/content/journals/10.5339/jemtac.2024.midc.3
Loading

Data & Media loading...

Keyword(s): hyaluronic acid, platelet-rich plasma, salivary matrix metalloproteinases and tempromandibular internal derrangment

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error