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oa A Thalassemic Adolescent Presented With Bone Pain, Tetanic Contractions and Growth delay: Combined vitamin D and Parathyroid defects
- Source: Qatar Medical Journal, Volume 2009, Issue 1, May 2009, 21
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- 01 May 2009
Abstract
Parathyroid hormone (PTH) and l,25-(OH) 2 vitamin D play key roles in the regulation of calcium and phosphate balance. Circulating levels of PTH can change within seconds after an alteration in serum calcium. When the serum calcium falls PTH is rapidly released and acts quickly to promote calcium reabsorption in the distal tubule and the medullary thick ascending limb of the loop of Henley. PTH also stimulates the release of calcium from the rapidly exchangeable pool of bone calcium and a chronic elevation in serum PTH increases renal l,25-(OH) 2 vitamin D production.
© 2009 Al Hemaidi, Soliman, licensee Bloomsbury Qatar Foundation Journals.