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Volume 2014, Issue 1
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

We conducted a retrospective cohort study to evaluate the clinical manifestations, laboratory findings, complications and treatment of brucellosis in the State of Qatar. The medical records of patients in Hamad Medical Corporation, Doha, Qatar were reviewed from January 2000 to December 2006. History, various socio-demographic features, clinical and biochemical parameters, therapeutic features, and complications were retrospectively collected from the patient database. Around three quarters of the study population were males. History of raw milk consumption and animal contact were seen in 41.7% and 12.5% respectively. The main presenting features of our cohort were fever, chills and sweating (93.1%, 62.5% and 58.3% respectively). Positive antibody titre (>1:160) was detected in 95.8% and positive blood culture was reported in 63.9% of the cohort. Splenomegaly was observed in 19.4%, hepatomegaly in 15.3% and lymphadenopathy in 9.7% of the cases. Approximately half of our patients were treated with a combination of doxycycline and streptomycine and nearly one quarter received doxycycline and rifampicine combination therapy. Brucellosis is an important public health problem worldwide. It is associated with significant morbidity and mortality. It may affect any organ system and can present with a variety of clinical features. Diagnosis of brucellosis requires serological tests with or without blood culture. Treatment with at least two antibiotics for six weeks or more appears to be effective.

© 2014 Rahil, Othman, Ibrahim, Mohamed, licensee Bloomsbury Qatar Foundation Journals.
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2014-07-01
2024-11-20
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References

  1. Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis. 2006; 6::91–99.
     [Google Scholar]
  2. Awad R. Human brucellosis in the Gaza strip, Palestine. East Mediterr Health J. 1998; 4::225–233.
     [Google Scholar]
  3. Naparstek E, Block CS, Slavin S. Transmission of brucellosis by bone marrow transplantation. Lancet. 1982; 1:8271:574–575.
     [Google Scholar]
  4. Lubani M, Sharda D, Helin I. Probable transmission of brucellosis from breast milk to a newborn. Trop Geogr Med. 1988; 40:2:151–152.
     [Google Scholar]
  5. Mantur BG, Mangalgi SS, Mulimani M. Brucella melitensis–a sexually transmissible agent? Lancet. 1996; 347:9017:1763.
     [Google Scholar]
  6. Tikare NV, Mantur BG, Bidari LH. Brucellar meningitis in an infant–evidence for human breast milk transmission. J Trop Pediatr. 2008; 54:4:272–274.
     [Google Scholar]
  7. Kochar DK, Gupta BK, Gupta A, Kalla A, Nayak KC, Purohit SK. Hospital-based case series of 175 cases of serologically confirmed brucellosis in Bikaner. J Assoc Physicians India. 2007; 55::271–275.
     [Google Scholar]
  8. Mantur BG, Amarnath SK, Shinde RS. Review of clinical and laboratory features of human brucellosis. Indian J Med Microbiol. 2007; 25:3:188–202.
     [Google Scholar]
  9. Mousa AR, Muhtaseb SA, Almudallal DS, Khodeir SM, Marafie AA. Osteoarticular complications of brucellosis: a study of 169 cases. Rev Infect Dis. 1987; 9:3:531–543.
     [Google Scholar]
  10. Nicoletti P. Control, eradication and prevention of brucellosis. In: Madkour MM, ed. Brucellosis. New York: Springer 2001;:280–285.
     [Google Scholar]
  11. FAO/WHO. Report, Joint FAO/WHO Expert Committee on Brucellosis. Technical Report Series No. 740. Geneva: World Health Organization 1986.
     [Google Scholar]
  12. Ariza J, Gudiol F, Pallares R, Rufi G, Fernandez-Viladrich P. Comparative trial of rifampin-doxycycline versus tetracycline-streptomycin in the therapy of human brucellosis. Antimicrob Agents Chemother. 1985; 28:4:548–551.
     [Google Scholar]
  13. Mantur BG, Biradar MS, Bidri RC, Mulimani MS, Veerappa , Kariholu P, Patil SB, Mangalgi SS. Protean clinical manifestations and diagnostic challenges of human brucellosis in adults: 16 years’ experience in an endemic area. J Med Microbiol. 2006; 55:Pt 7:897–903.
     [Google Scholar]
  14. Solera J, Martinez-Alfaro E, Espinosa A, Castillejos ML, Geijo P, Rodriguez-Zapata M. Multivariate model for predicting relapse in human brucellosis. J Infect Dis. 1998; 36::85–92.
     [Google Scholar]
  15. Fallatah SM, Oduloju AJ, Al-Dusari SN, Fakunle YM. Human brucellosis in Northern Saudi Arabia. Saudi Med J. 2005; 26:10:1562–1566.
     [Google Scholar]
  16. Jennings GJ, Hajjeh RA, Girgis FY, Fadeel MA, Maksoud MA, Wasfy MO, El-Sayed N, Srikantiah P, Luby SP, Earhart K, Mahoney FJ. Brucellosis as a cause of acute febrile illness in Egypt. Trans R Soc Trop Med Hyg. 2007; 101:7:707–713.
     [Google Scholar]
  17. Buzgan T, Karahocagil MK, Irmak H, Baran AI, Karsen H, Evirgen O, Akdeniz H. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis. 2010; 14:6:e469–e478.
     [Google Scholar]
  18. Tanir G, Tufekci SB, Tuygun N. Presentation, complications, and treatment outcome of brucellosis in Turkish children. Pediatr Int. 2009; 51::114–119.
     [Google Scholar]
  19. Ulug M, Can-Ulug N, Selek Ç. Akut brusellozlu hastalarda akut faz reaktanlarinin düzeyi. Klimik Dergisi. 2010; 23::48–50.
     [Google Scholar]
  20. Al-Eissa Y, AI-Nasser M. Hematological manifestation of childhood brucellosis. Infection. 1993; 21::23–26.
     [Google Scholar]
  21. Dilek I, Durmus A, Karahocagil MK, Akdenyz H, Karsen H, Baran AI, Evirgen Ö. Hematological complications in 787 cases of acute brucellosis in eastern Turkey. Turk J Med Sci. 2008; 38::421–424.
     [Google Scholar]
  22. Ertek M, Yazgi H, Kadanali A, Ozden K, Tasyaran MA. Complications of Brucella infection among adults: an 18-year retrospective evaluation. Turk J Med Sci. 2006; 36::377–381.
     [Google Scholar]
  23. Bukharie HA. Clinical features, complications and treatment outcome of Brucella infection: ten years’ experience in an endemic area. Trop J Pharm Res. 2009; 8::303–310.
     [Google Scholar]
  24. Lulu AR, Araj GF, Khateeb MI, Mustafa MY, Yusuf AR, Fenech FF. Human brucellosis in Kuwait: a prospective study of 400 cases. QJ Med. 1988; 66::39–54.
     [Google Scholar]
/content/journals/10.5339/qmj.2014.4
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Brucellosis in Qatar: A retrospective cohort study
Qatar Medical Journal 2014, 4 (2014); https://doi.org/10.5339/qmj.2014.4
/content/journals/10.5339/qmj.2014.4
/content/journals/10.5339/qmj.2014.4
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  • Article Type: Research Article
Keyword(s): Brucellosis, Malta fever, Middle East and Qatar

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