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Volume 2020, Issue 1
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

Low serum vitamin D levels are reported constantly among females living in the Arabian Gulf countries, presumably due to their lifestyle, which limits direct sun exposure. Because Vitamin D deficiency has been implicated in a wide range of ailments, healthy females with the deficiency might be at risk for developing many health problems. Thus, the aim was to assess lifestyle risk factors for vitamin D deficiency in healthy women in Kuwait. A total of 104, disease-free, premenopausal women were recruited for assessment of their serum 25OHD and intact PTH levels. Physical examination, blood withdrawal and interviewer-administered questionnaires were used to collect the relevant data. Associations were detected statistically using nonparametric tests and logistic regression was used to identify risk factors for vitamin D deficiency. Vitamin D deficiency ( < 25 nmol/L) occurred in 84.6%, and hyperparathyroidism ( ≥ 6.9 pmol/L) occurred in 25% of women, among which all were vitamin D deficient. Significant risk factors of vitamin D deficiency were nondaily milk intake (OR:25, CI%:4.2–147), no fish intake (OR:5, CI%:1–22.8), and no weekend sun exposure (OR:8.2, CI%:1.28–52.6). Having PTH ≥ 6 pmol/L was also associated with a higher likelihood of having vitamin D deficiency. Vitamin D deficiency is very common in disease-free, premenopausal Kuwaiti women and can be avoided by improving food consumption and obtaining more sun exposure.

© 2020 Alyahya, licensee HBKU Press.
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2020-05-04
2024-11-14
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References

  1. Gordon CM, DePeter KC, Feldman HA, Grace E, Emans SJ. Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med. 2004; 158::531–537.
     [Google Scholar]
  2. Elizondo-Montemayor L, Ugalde-Casas PA, Serrano-González M, Cuello-García CA, Borbolla-Escoboza JR. Serum 25-hydroxyvitamin d concentration, life factors and obesity in Mexican children. Obesity. 2010; 18::1805–1811.
     [Google Scholar]
  3. Golbahar J, Al-Saffar N, Diab DA, Al-Othman S, Darwish A, Al-Kafaji G. Predictors of vitamin D deficiency and insufficiency in adult Bahrainis: a cross-sectional study. Public Health Nutr. 2014; 17::732–738.
     [Google Scholar]
  4. Tamer G, Mesci B, Tamer I, Kilic D, Arik S. Is vitamin D deficiency an independent risk factor for obesity and abdominal obesity in women? Endokrynol Pol. 2012; 63::196–201.
     [Google Scholar]
  5. Hatun S, Islam O, Cizmecioglu F, Kara B, Babaoglu K, Berk F, et al.  Subclinical vitamin D deficiency is increased in adolescent girls who wear concealing clothing. J Nutr. 2005; 135::218–222.
     [Google Scholar]
  6. Goaziou MFL, Contardo G, Dupraz C, Martin A, Laville M, Schott-Pethelaz AM. Risk factors for vitamin D deficiency in women aged 20-50 years consulting in general practice: a cross-sectional study. Eur J Gen Pract. 2011; 17::146–152.
     [Google Scholar]
  7. Alyahya K, Lee WT, Al-Mazidi Z, Morgan J, Lanham-New S. Risk factors of low vitamin D status in adolescent females in Kuwait: implications for high peak bone mass attainment. Arch Osteoporos. 2014; 9::178.
     [Google Scholar]
  8. Khundmiri S, Murray R, Lederer E. PTH and vitamin D. Compr Physiol. 2016; 6::561.
     [Google Scholar]
  9. Itkonen S, Erkkola M, Lamberg-Allardt C. Vitamin D fortification of fluid milk products and their contribution to vitamin D intake and vitamin D status in observational studies-A review. Nutrients. 2018; 10::1054.
     [Google Scholar]
  10. Bassil D, Rahme M, Hoteit M, Fuleihan GE-H. Hypovitaminosis D in the Middle East and North Africa: prevalence, risk factors and impact on outcomes. Dermatoendocrinol. 2013; 5::274–298.
     [Google Scholar]
  11. Batieha A, Khader Y, Jaddou H, Hyassat D, Batieha Z, Khateeb M, et al.  Vitamin D status in Jordan: dress style and gender discrepancies. Ann Nutr Metab. 2011; 58::10–18.
     [Google Scholar]
  12. Hovsenpian S, Amini M, Aminorroaya A, Amini P, Iraj B. Prevalence of vitamin D deficiency among adult population of Isfahan city. Iran. J Health Popul Nutr. 2011; 29::149–155.
     [Google Scholar]
  13. Narchi H, Kochiyil J, Hamad SA, Yasin J, Laleye L, Dhaheri AA. Hypovitaminosis D in adolescent females-an analytical cohort study in the United Arab Emirates. Paediatr Int Child Health. 2015; 35::36–43.
     [Google Scholar]
  14. Siddiqui A, Kamfar H. Prevalence of vitamin D deficiency rickets in adolescent school girls in Western region. Saudi Arabia. Saudi Med J. 2007;28.
     [Google Scholar]
  15. Bener A, Al-Ali M, Hoffmann GF. Vitamin D deficiency in healthy children in a sunny country: associated factors. Int J Food Sci Nutr. 2009; 60::60–70.
     [Google Scholar]
  16. Alsuwaida A, Farag Y, Al-Sayyari A, Mousa D, Alhejaili F, A-Harib A, et al. Prevalence of vitamin D deficiency in Suadi adults. Saudi Med J. 2013; 34::814–818.
     [Google Scholar]
  17. Alyahya KO. Vitamin D levels in schoolchildren: a cross-sectional study in Kuwait. BMC Pediatr. 2017; 17::213.
     [Google Scholar]
  18. Al-Taiar A, Rahman A, Al-Sabah R, Shaban L, Al-Harbi A. Vitamin D status among adolescents in Kuwait: a cross-sectional study. BMJ Open. 2018;8.
     [Google Scholar]
  19. Tabachnick B, Fidell L. Using multivariate statistics.4th ed.Pearson Education;2001.
     [Google Scholar]
  20. Sachdeva S. Fitzpatrick skin typing: applications in dermatology. Indian J Dermatol Venereol Leprol. 2009; 75::93–96.
     [Google Scholar]
  21. Lamberg-Allardt C, Brustad M, Meyer HE, Steingrimsdottir L. Vitamin D - a systematic literature review for the 5th edition of the Nordic Nutrition Recommendations. Food Nutr Res. 2013; 57::22671.
     [Google Scholar]
  22. Badawi A, Arora P, Sadoun E, Al-Thani A-A, Al-Thani M. Prevalence of vitamin D insufficiency in Qatar: a systematic review. J Public Health Res. 2012; 1::229–235.
     [Google Scholar]
  23. Arabi A, El Rassi R, Fuleihan GE-H. Hypovitaminosis D in developing countries—prevalence, risk factors and outcomes. Nat Rev Endocrinol. 2010; 6::550–561.
     [Google Scholar]
  24. Islam MZ, Akhtaruzzaman M, Lamberg-Allardt C. Hypovitaminosis D is common in both veiled and nonveiled Bangladeshi women. Asia Pac J Clin Nutr. 2006; 15::81.
     [Google Scholar]
  25. Al-Yatama FI, AlOtaibi F, Al-Bader MD, Al-Shoumer KA. The effect of clothing on vitamin D status, bone turnover markers, and bone mineral density in young Kuwaiti females. Int. J. Endocrinol. 2019;2019.
     [Google Scholar]
  26. Al-Othman A, Al-Musharaf S, Al-Daghri NM, Krishnaswamy S, Yusuf DS, Alkharfy KM, et al.  Effect of physical activity and sun exposure on vitamin D status of Saudi children and adolescents. BMC Pediatr. 2012; 12::92.
     [Google Scholar]
  27. MacLaughlin J, Holick MF. Aging drecreses the capacity of human skin to produce vitamin D3. J Clin Invest. 1985; 76::1536–1538.
     [Google Scholar]
  28. Forrest K, Stuhldreher W. Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res. 2011; 31::48–54.
     [Google Scholar]
  29. Tolppanen A-M, Fraser A, Fraser W, Lawlor D. Risk factors for variation in 25-hydroxyvitamin D3 and D2 concentrations and vitamin D deficiency in children. J Clin Endocrinol Metab. 2012; 97::1202–1210.
     [Google Scholar]
  30. Alvi S, Tabache C, Al-Ashwall A, Hammami M. Vitamin D content in fortified low fat milk in Saudi Arabia. Ann Saudi Med. 2016; 36::325–327.
     [Google Scholar]
  31. Schmid A, Walther B. Natural vitamin D content in animal products. Adv Nutr. 2013; 4::453–462.
     [Google Scholar]
  32. Nakamura K, Nashimoto M, Okuda Y, Ota T, Yamamoto M. Fish as a major source of vitamin D in the Japanese diet. Nutrition. 2002; 18::415.
     [Google Scholar]
  33. Brustad M, Sandanger T, Aksnes L, Lund E. Vitamin D status in a rural population of northen Norway with high fish liver consumption. Public Health Nutr. 2004; 7::783–789.
     [Google Scholar]
  34. Hever J. Plant-based diets: a physician's guide. Perm J. 2016; 20::15–82.
     [Google Scholar]
  35. Holick MF, Chen T. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008; 87::1080–1086.
     [Google Scholar]
  36. Aloia JF, Feuerman M, Yeh J. Reference range for serum parathyroid hormone. Endocr Pract. 2006; 12::134–144.
     [Google Scholar]
  37. Steingrimsdottir L, Gunnarsson O, Indridason OS, Franzson L, Sigurdsson G. Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. Jama. 2005; 294::2336–2341.
     [Google Scholar]
  38. Kroll M, Bi C, Garber C, Kaufman H, Liu D, Caston-Balderrama A, et al.  Temporal relationship between vitamin D status and prathyroid hormone in the United States. PloS One. 2015;10.
     [Google Scholar]
  39. Aloia JF, Chen D-G, Chen H. The 25(OH)D/PTH threshold in black women. J Clin Endocrinol Metab. 2010; 95::5069–5073.
     [Google Scholar]
  40. AlQuaiz AM, Mujammami M, Kazi A, Hasanato RM, Alodhayani A, Shaik SA, et al.  Vitamin D cutoff point in relation to parathyroid hormone: a population based study in Riyadh city. Saudi Arabia. Arch Osteoporos. 2019; 14::22.
     [Google Scholar]
  41. Mezzavilla M, Tomei S, Alkayal F, Melhem M, Ali M, Al-Arouj M, et al.  Investigation of genetic variation and lifestyle determinants in vitamin D levels in Arab individuals. J Transl Med. 2018; 16::20.
     [Google Scholar]
  42. Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol. 2014; 2::76–89.
     [Google Scholar]
  43. Karras S, Anagnostis P, Antonop V. The combined effect of vitamin D and parathyroid hormone concentrations on glucose homeostasis in older patients with prediabetes: A cross-sectional study. Diab Vasc Dis Res. 2018; 15::150–153.
     [Google Scholar]
  44. El Hilali J, de Koning EJ, van Ballegooijen AJ, Lips P, Sohl E, van Marwijk HW, Vitamin D, et al.  PTH and the risk of overall and disease-specific mortality: results of the Longitudinal Aging Study Amsterdam. J Steroid Biochem Mol Biol. 2016; 164::386–394.
     [Google Scholar]
/content/journals/10.5339/qmj.2020.15
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Poor dietary consumption and limited sun exposure are risk factors for vitamin D deficiency in premenopausal Kuwaiti women: A cross-sectional study
Qatar Medical Journal 2020, 15 (2020); https://doi.org/10.5339/qmj.2020.15
/content/journals/10.5339/qmj.2020.15
/content/journals/10.5339/qmj.2020.15
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  • Article Type: Research Article
Keyword(s): 25OHD, Kuwait, PTH, vitamin D and women

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