1887
  1. Home
  2. A-Z Publications
  3. Qatar Medical Journal
  4. Volume 2021, Issue 3
  5. Article
Volume 2021, Issue 3
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

Blood groups are inherited traits that affect the susceptibility/severity of a disease. A clear relationship between coronavirus disease 2019 (COVID-19) and ABO blood groups is yet to be established in the Indian population. This study aimed to demonstrate an association of the distribution and severity of COVID-19 with ABO blood groups. A cross-sectional study was conducted after obtaining ethics approval (IEC 207/20) among hospitalized patients using in-patient records and analyzed on SPSS-25. Chi-square tests were used for the analysis of categorical data and independent sample t-test/Mann–Whitney U tests were used for continuous data. The B blood group had the highest prevalence among COVID-19-positive patients. The AB blood group was significantly associated with acute respiratory distress syndrome (ARDS) ( = 0.03), sepsis ( = 0.02), and septic shock ( = 0.02). The O blood group was associated with significantly lower rates of lymphopenia and leucocytosis. However, no significant clinical association was seen in the O blood group. This study has demonstrated that blood groups have a similar distribution among patients hospitalized with COVID-19 in the South Indian population. Additionally, it preludes to a possible association between the AB blood group and ARDS, sepsis, and septic shock. Further studies having a larger representation of AB blood groups, especially in patients hospitalized for critical COVID-19, with adjustment for possible covariates, are warranted to provide a reliable estimate of the risk in the South Indian population.

© 2021 Pasangha, Dhali, D'Souza, Umesh, licensee HBKU Press.
Loading

Article metrics loading...

/content/journals/10.5339/qmj.2021.63
2021-10-21
2024-11-05
Loading full text...

Full text loading...

/deliver/fulltext/qmj/2021/3/qmj.2021.63.html?itemId=/content/journals/10.5339/qmj.2021.63&mimeType=html&fmt=ahah

References

  1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020 20; 382:(8):727–33.
     [Google Scholar]
  2. WHO Coronavirus Disease (COVID-19) Dashboard [Internet]. [cited 2020 Nov 3]. Available from: https://covid19.who.int .
     [Google Scholar]
  3. MoHFW | Home [Internet]. [cited 2021 May 8]. Available from: https://www.mohfw.gov.in/.
     [Google Scholar]
  4. Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Apr 30; 382:(18):1708–20.
     [Google Scholar]
  5. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020 Mar 17; 323:(11):1061.
     [Google Scholar]
  6. Schiffrin EL, Flack JM, Ito S, Muntner P, Webb RC. Hypertension and COVID-19. Am J Hypertens. 2020 Apr 29;33(5):373–4.
     [Google Scholar]
  7. Singh AK, Misra A. Impact of COVID-19 and comorbidities on health and economics: Focus on developing countries and India. Diabetes Metab Syndr. 2020 Dec; 14:(6):1625–30.
     [Google Scholar]
  8. Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72-314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020 07; 323:(13):1239–42.
     [Google Scholar]
  9. Cheng L, Li H, Li L, Liu C, Yan S, Chen H, et al. Ferritin in the coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis. J Clin Lab Anal. 2020 Oct; 34:(10):e23618.
     [Google Scholar]
  10. Soraya GV, Ulhaq ZS. Crucial laboratory parameters in COVID-19 diagnosis and prognosis: An updated meta-analysis. Med Clin Engl Ed. 2020 Aug 28; 155:(4):143–51.
     [Google Scholar]
  11. Clinical management of COVID-19 [Internet]. [cited 2020 Nov 10]. Available from: https://www.who.int/publications/i/item/clinical-management-of-covid-19 .
     [Google Scholar]
  12. Li J, Wang X, Chen J, Cai Y, Deng A, Yang M. Association between ABO blood groups and risk of SARS-CoV-2 pneumonia. Br J Haematol. 2020 Jul; 190:(1):24–7.
     [Google Scholar]
  13. Anstee DavidJ. The relationship between blood groups and disease. Blood. 2010 Jun 10; 115:(23):4635–43.
     [Google Scholar]
  14. Raza MW, Blackwell CC, Molyneaux P, James VS, Ogilvie MM, Inglis JM, et al. Association between secretor status and respiratory viral illness. BMJ. 1991 Oct 5; 303:(6806):815–8.
     [Google Scholar]
  15. Zietz M, Tatonetti NP. Testing the association between blood type and COVID-19 infection, intubation, and death. MedRxiv Prepr Serv Health Sci. 2020Apr 11.
     [Google Scholar]
  16. Hoiland RL, Fergusson NA, Mitra AR, Griesdale DEG, Devine DV, Stukas S, et al. The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19. Blood Adv. 2020 Oct 27; 4:(20):4981–9.
     [Google Scholar]
  17. Padhi S, Suvankar S, Dash D, Panda VK, Pati A, Panigrahi J, et al. ABO blood group system is associated with COVID-19 mortality: An epidemiological investigation in the Indian population. Transfus Clin Biol J Soc Francaise Transfus Sang. 2020 Nov; 27:(4):253–8.
     [Google Scholar]
  18. Singh PP, Srivastava AK, Upadhyay SK, Singh A, Gupta P, Maurya S, et al. The association of ABO blood group with the asymptomatic COVID-19 cases in India [Internet]. Public and Global Health; 2021 Apr [cited 2021 Jun 4]. Available from: http://medrxiv.org/lookup/doi/10.1101/2021.04.01.21254681 .
     [Google Scholar]
  19. Our World in Data [Internet]. Our World in Data. [cited 2020 Nov 3]. Available from: https://ourworldindata.org .
     [Google Scholar]
  20. Wu Y, Feng Z, Li P, Yu Q. Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19. Clin Chim Acta Int J Clin Chem. 2020 Oct;509:220–3.
     [Google Scholar]
  21. Dr. NTR University of Health sciences, Vijayawada, Andhra Pradesh, India, Bhavani DrC, Swapna DRS, Dr. NTR University of Health Sciences, Vijayawada, Andhra Pradesh, India, M. DN, Dr. NTR University of Health sciences, Vijayawada, Andhra Pradesh, India, et al. Distribution of ABO blood groups and Rh(D) factor in and around Anatapuramu, Andhra Pradesh. Int J Med Res Rev. 2016 Mar 31; 4:(3):372–5.
     [Google Scholar]
  22. Luo J-Q, He F-Z, Luo Z-Y, Wen J-G, Wang L-Y, Sun N-L, et al. Rs 495828 polymorphism of the ABO gene is a predictor of enalapril-induced cough in Chinese patients with essential hypertension. Pharmacogenet Genomics. 2014 Jun; 24:(6):306–13.
     [Google Scholar]
  23. Levi JE, Telles PR, Scrivani H, Oliveira FP, Vieira LC, Dias CM, et al. LACK OF ASSOCIATION BETWEEN ABO BLOOD GROUPS AND SUSCEPTIBILITY TO SARS-COV-2 INFECTION. Hematol Transfus Cell Ther. 2020 Nov;42:541–2.
     [Google Scholar]
  24. Zhou B, Wu N, Zhu C, Gao Y, Guo Y, Qing P, et al. ABO blood group is a risk factor for coronary artery disease in patients with poor blood pressure control. Clin Exp Hypertens N Y N 1993. 2017; 39:(4):366–70.
     [Google Scholar]
  25. Zheng Y, Huang Z, Yin G, Zhang X, Ye W, Hu Z, et al. Comparative study of the lymphocyte change between COVID-19 and non-COVID-19 pneumonia cases suggesting uncontrolled inflammation might not be the main reason of tissue injury [Internet]. Infectious Diseases (except HIV/AIDS); 2020 Feb [cited 2021 Jun 4]. Available from: http://medrxiv.org/lookup/doi/10.1101/2020.02.19.20024885 .
     [Google Scholar]
  26. Panda AK, Panda SK, Sahu AN, Tripathy R, Ravindran B, Das BK. Association of ABO blood group with severe falciparum malaria in adults: case control study and meta-analysis. Malar J. 2011 Oct 19;:10:309.
     [Google Scholar]
/content/journals/10.5339/qmj.2021.63
Loading
Are blood groups related to the distribution and severity of COVID-19? A cross-sectional study in a tertiary care hospital in South India
Qatar Medical Journal 2021, 63 (2021); https://doi.org/10.5339/qmj.2021.63
/content/journals/10.5339/qmj.2021.63
/content/journals/10.5339/qmj.2021.63
Loading

Data & Media loading...

Keyword(s): ABO blood groups, coronavirus and COVID-19

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error