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Volume 2023, Issue 4
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

Introduction: Chronic kidney disease (CKD) is a global health problem. Reduced innate and adaptive immunological responses predispose CKD patients to infections. Despite the clinical and epidemiological importance of CKD and the great value of vaccination as a prophylactic measure, the utilization of recommended vaccines in Qatar has not yet been evaluated.

Methods: We conducted a cross-sectional study to estimate the level of influenza, pneumococcal, and hepatitis B vaccination and the predictors of adherence to these recommended vaccines among non-dialysis CKD patients receiving renal ambulatory care in Qatar from 1 September 2020 to 30 April 2021. Complete vaccination was defined as receiving the three vaccines, and partial vaccination was defined as receiving one or two vaccines. The full and partial vaccination predictors were assessed using multivariate logistic regression and reported as odds ratio (OR) with p<0.05 indicating statistical significance.

Results: 416 non-dialysis CKD patients were included in our analysis. 73% were males; the mean age was 56 ± 15 years. More than 50% of the patients were from the Middle East, followed by 36% from Asia. Most patients had concurrent hypertension, concurrent diabetes mellitus, and were stage V CKD. Only 12% of the patients were fully vaccinated, while 73% received partial vaccination. The predictors of vaccination included age, gender, Asian origin, employment, living conditions, concurrent medical conditions, CKD stage, allergy to medications, and use of injectable medications. Only stage V CKD positively predicted adherence to full and partial vaccinations in non-dialysis CKD patients.

Conclusion: There is very low adherence to the recommended vaccines in CKD patients, with a prevalence of complete vaccination of 12% only. Increased public awareness about the importance of vaccination in CKD may improve the adherence rates among these patients in Qatar.

© 2023 Habib, Ali, Rahhal, Obeidat, Altermanini, Sawaf, Latif, Hamad, Bougmiza, Aly, Mahmoud, Licensee HBKU Press.
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2024-01-02
2024-11-08
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References

  1. United States Renal Data System [Internet] . Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States c2013 [cited 2023 Jan 31]. Available from: https://www.niddk.nih.gov/about-niddk/strategic-plans-reports/usrds/prior-data-reports/2013.
     [Google Scholar]
  2. Mills KTXu YZhang WBundy JDChen CSKelly TNChen JHe J. A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010. Kidney Int. 2015 Nov;88:(5):950–7. doi: 10.1038/ki.2015.230.
     [Google Scholar]
  3. Drey NRoderick PMullee MRogerson M. A population-based study of the incidence and outcomes of diagnosed chronic kidney disease. Am J Kidney Dis. 2003 Oct;42:(4):677–84. doi: 10.1016/s0272-6386(03)00916-8.
     [Google Scholar]
  4. Chapter 1: Definition and classification of CKD . Kidney Int Suppl (2011). 2013 Jan;3:(1):19–62. doi: 10.1038/kisup.2012.64.
     [Google Scholar]
  5. Myers GLMiller WGCoresh JFleming JGreenberg NGreene T et al.. Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem. 2006 Jan;52:(1):5–18. doi: 10.1373/clinchem.2005.0525144.
     [Google Scholar]
  6. Collins AJFoley RNHerzog CChavers BGilbertson DIshani A et al.. US Renal Data System 2010 Annual Data Report. Am J Kidney Dis. 2011 Jan; 57:(1 Suppl 1):A8, e1-526. doi: 10.1053/j.ajkd.2010.10.007.
     [Google Scholar]
  7. Popovic JRKozak LJ. National hospital discharge survey: annual summary, 1998. Vital Health Stat 13. 2000 Sep;(148):1-194.
     [Google Scholar]
  8. GBD 2015 DALYs and HALE Collaborators . Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016 Oct 8;388:(10053):1603-1658. doi: 10.1016/S0140-6736(16)31460-X.
     [Google Scholar]
  9. Hamdi AFFawzy AAbuhelaiqa EAsim MNuaman AAshur A et al.. Risk factors associated with chronic kidney disease progression: Long-term retrospective analysis from Qatar. Qatar Med J. 2022 Nov 30;2022:(4):57. doi: 10.5339/qmj.2022.57.
     [Google Scholar]
  10. Reddy SChitturi CYee J. Vaccination in Chronic Kidney Disease. Adv Chronic Kidney Dis. 2019 Jan;26:(1):72–78. doi: 10.1053/j.ackd.2018.10.002.
     [Google Scholar]
  11. DaRoza GLoewen ADjurdjev OLove JKempston CBurnett S et al.. Stage of chronic kidney disease predicts seroconversion after hepatitis B immunization: earlier is better. Am J Kidney Dis. 2003 Dec;42:(6):1184–92. doi: 10.1053/j.ajkd.2003.08.019.
     [Google Scholar]
  12. Kim DKRiley LEHunter PBridges CBWoods LWilson A. Recommended Immunization Schedule for Adults Aged 19 Years or Older, United States, 2018. Ann Intern Med 2018; 168::210–20. doi: 10.7326/M17-3439.
     [Google Scholar]
  13. Sarnak MJJaber BL. Pulmonary infectious mortality among patients with end-stage renal disease. Chest. 2001 Dec;120:(6):1883–7. doi: 10.1378/chest.120.6.1883.
     [Google Scholar]
  14. Janus NVacher LVKarie SLedneva EDeray G. Vaccination and chronic kidney disease. Nephrol Dial Transplant. 2008 Mar;23:(3):800–7. doi: 10.1093/ndt/gfm851.
     [Google Scholar]
  15. Hamad AAl Halabi AMGhazouani HHabas EMBorham AMIsmail SM et al.. Time-Series Forecasting of Hemodialysis Population in the State of Qatar by 2030. Qatar Med J. 2023 Feb 20;2023:(1):6. doi: 10.5339/qmj.2023.6.
     [Google Scholar]
  16. rueger KMIson MGGhossein C. Practical Guide to Vaccination in All Stages of CKD, Including Patients Treated by Dialysis or Kidney Transplantation. Am J Kidney Dis. 2020 Mar;75:(3):417–425. doi: 10.1053/j.ajkd.2019.06.014.
     [Google Scholar]
  17. Qatar monthly statistics population by gender [Internet]. Qatar Open Data, c2023 [cited 2023 Oct 16]. Available from: https://www.data.gov.qa/explore/dataset/qatar-monthly-statistics-population-by-gender/table/?sort=month&dataChart=eyJxdWVyaWVzIjpbeyJjaGFydHMiOlt7InR5c n.d.
     [Google Scholar]
  18. Anding KGross PRost JMAllgaier DJacobs E. The influence of uraemia and haemodialysis on neutrophil phagocytosis and antimicrobial killing. Nephrol Dial Transplant. 2003 Oct;18:(10):2067–73. doi: 10.1093/ndt/gfg330.
     [Google Scholar]
  19. Meier PDayer EBlanc EWauters JP. Early T cell activation correlates with expression of apoptosis markers in patients with end-stage renal disease. J Am Soc Nephrol. 2002 Jan;13:(1):204–212. doi: 10.1681/ASN.V131204.
     [Google Scholar]
  20. Litjens NHvan Druningen CJBetjes MG. Progressive loss of renal function is associated with activation and depletion of naive T lymphocytes. Clin Immunol. 2006 Jan;118:(1):83–91. doi: 10.1016/j.clim.2005.09.007.
     [Google Scholar]
  21. Gollapudi PYoon JWGollapudi SPahl MVVaziri ND. Leukocyte toll-like receptor expression in end-stage kidney disease. Am J Nephrol. 2010;31:(3):247-54. doi: 10.1159/000276764.
     [Google Scholar]
  22. Kato SChmielewski MHonda HPecoits-Filho RMatsuo SYuzawa YTranaeus AStenvinkel PLindholm B. Aspects of immune dysfunction in end-stage renal disease. Clin J Am Soc Nephrol. 2008 Sep;3:(5):1526–33. doi: 10.2215/CJN.00950208.
     [Google Scholar]
  23. Ishigami JMatsushita K. Clinical epidemiology of infectious disease among patients with chronic kidney disease. Clin Exp Nephrol. 2019 Apr;23:(4):437–447. doi: 10.1007/s10157-018-1641-8.
     [Google Scholar]
  24. Doherty MSchmidt-Ott RSantos JIStanberry LRHofstetter AMRosenthal SL et al.. Vaccination of special populations: Protecting the vulnerable. Vaccine. 2016 Dec 20;34:(52):6681-6690. doi: 10.1016/j.vaccine.2016.11.015.
     [Google Scholar]
  25. Miller ERAlter MJTokars JI. Protective effect of hepatitis B vaccine in chronic hemodialysis patients. Am J Kidney Dis. 1999 Feb;33:(2):356–60. doi: 10.1016/s0272-6386(99)70312-4.
     [Google Scholar]
  26. Zitt EHafner-Giessauf HWimmer BHerr AHorn SFriedl C et al.. Response to active hepatitis B vaccination and mortality in incident dialysis patients. Vaccine. 2017 Feb 1;35:(5):814-820. doi: 10.1016/j.vaccine.2016.12.032.
     [Google Scholar]
  27. Vandecasteele SJOmbelet SBlumental SPeetermans WE. The ABC of pneumococcal infections and vaccination in patients with chronic kidney disease. Clin Kidney J. 2015 Jun;8:(3):318–24. doi: 10.1093/ckj/sfv030.
     [Google Scholar]
  28. Viasus DGarcia-Vidal CCruzado JMAdamuz JVerdaguer RManresa F et al.. Epidemiology, clinical features and outcomes of pneumonia in patients with chronic kidney disease. Nephrol Dial Transplant. 2011 Sep;26:(9):2899–906. doi: 10.1093/ndt/gfq798.
     [Google Scholar]
  29. Remschmidt CWichmann OHarder T. Influenza vaccination in patients with end-stage renal disease: systematic review and assessment of quality of evidence related to vaccine efficacy, effectiveness, and safety. BMC Med. 2014 Dec 19;12::244. doi: 10.1186/s12916-014-0244-9.
     [Google Scholar]
  30. Hettenbaugh JMullane RGillispie GShostrom VFlores LFillaus JA et al.. Hepatitis B Vaccination in Advanced Chronic Kidney Disease: A Quality Improvement Project at a Veteran Affairs Chronic Kidney Disease Clinic. Infect Dis Rep. 2021 Dec 6;13:(4):1036-1042. doi: 10.3390/idr13040094.
     [Google Scholar]
  31. Asim MAlkadi MHamad AOthman MAbuhelaiqa EFituri O et al.. Restructuring nephrology services to combat COVID-19 pandemic: Report from a Middle Eastern country. World J Nephrol. 2020; 9:(2):9–17. doi: 10.5527/wjn.v9.i2.9.
     [Google Scholar]
  32. Hamad AIAsim MOthman MAAbuhelaiqa EAShurrab AElmadhoun IT et al.. National response to the COVID-19 Omicron variant crisis in the ambulatory hemodialysis service in the State of Qatar. Qatar Med J. 2022 Aug 23;2022:(3):38. doi: 10.5339/qmj.2022.38.
     [Google Scholar]
  33. Mathew RMason DKennedy JS. Vaccination issues in patients with chronic kidney disease. Expert Rev Vaccines. 2014 Feb;13:(2):285–98. doi: 10.1586/14760584.2014.874950.
     [Google Scholar]
  34. Hirst AHyer RNJanssen RS. Comparative cost-effectiveness of a 2-dose versus 3-dose vaccine for hepatitis B prevention in selected adult populations. Vaccine. 2021 Jul 30;39:(33):4733-4741. doi: 10.1016/j.vaccine.2021.05.020.
     [Google Scholar]
  35. Jaca AMathebula LIweze APienaar EWiysonge CS. A systematic review of strategies for reducing missed opportunities for vaccination. Vaccine. 2018 May 17;36:(21):2921-2927. doi: 10.1016/j.vaccine.2018.04.028.
     [Google Scholar]
  36. Mde CSato APWaldman EA. Factors associated with incomplete or delayed vaccination across countries: A systematic review. Vaccine. 2016 May 23;34:(24):2635-43. doi: 10.1016/j.vaccine.2016.04.016.
     [Google Scholar]
  37. Singh POthman MElgaali MAmin MEzzat MElsayed A et al.. Challenges to improve the Coronavirus disease 2019 (COVID-19) Immunization among the dialysis population in Hamad General Hospital in the Nephrology Division, Hamad Medical Corporation, Doha, State of Qatar. J Emerg Med Trauma Acute Care. 2022; 2022::42. doi: 10.5339/jemtac.2022.qhc.42.
     [Google Scholar]
  38. World Health Organization [Internet]. Global Vaccine Action Plan Monitoring, Evaluation & Accountability: Secretariat Annual Report 2020, c2020 [cited 2023 Jan 26]. Available from: https://www.who.int/publications/i/item/global-vaccine-action-plan-monitoring-evaluation-accountability-secretariat-annual-report-2020.
     [Google Scholar]
/content/journals/10.5339/qmj.2023.33
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Determinants of vaccine adherence among non-dialysis chronic kidney disease patients in Qatar
Qatar Medical Journal 2023, 33 (2024); https://doi.org/10.5339/qmj.2023.33
/content/journals/10.5339/qmj.2023.33
/content/journals/10.5339/qmj.2023.33
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  • Article Type: Research Article
Keyword(s): adherence, chronic kidney disease, hepatitis B, influenza, pneumococcal and vaccine

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