1887
  1. Home
  2. A-Z Publications
  3. Qatar Medical Journal
  4. Volume 2024, Issue 4
  5. Article
Volume 2024, Issue 4
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

Introduction: Neonatal sepsis (NS) is a major healthcare burden in Gulf Cooperation Council (GCC) countries, with a prevalence higher than the global average. Microbial drug resistance has major implications for mortality and morbidity from NS.

Objective: To synthesize data regarding the patterns of causative bacteria of NS in the GCC and their antimicrobial susceptibility profiles.

Methods: Following the exploration of four electronic databases, i.e., EBSCOhost, ProQuest, PubMed/MEDLINE, and ScienceDirect, eligible studies were identified (i.e., published between 2013 and 2023 and reported bacterial profile and/or antimicrobial susceptibility patterns). The outcomes included the pooled prevalence of bacteria and their susceptibility patterns. Proportion meta-analysis was performed for each outcome of interest.

Results: Fifteen studies were eligible (total positive cases = 2,473). Coagulase-negative (CoNS) (28.1%) were the most common gram-positive causative pathogen, followed by group B (GBS) (16.2%) and (9.9%); for gram-negative, (12.7%) and species (11.4%) were most common. The susceptibility rates of these bacteria to first-line antibiotics were high; gram-positive bacteria had the highest susceptibility to ampicillin (72.8–98%), and gram-negative bacteria was most susceptible to amikacin (94.6–98%). Additionally, both gram-positive (67–77%) and negative (87–93%) bacteria exhibited high susceptibility to gentamicin.

Conclusion: The most common pathogens among NS patients were gram-positive. The pathogens, irrespective of stain test, were susceptible to the current antibiotic therapy. We recommend the judicious use of empirical antibiotic therapy to prevent the growing risk of antimicrobial resistance.

© 2024 Jihwaprani, Sula, Coha, Alhebshi, Alsama, Hassaneen, et al., Licensee HBKU Press.
Loading

Article metrics loading...

/content/journals/10.5339/qmj.2024.62
2024-11-11
2024-11-20
Loading full text...

Full text loading...

/deliver/fulltext/qmj/2024/4/qmj.2024.62.html?itemId=/content/journals/10.5339/qmj.2024.62&mimeType=html&fmt=ahah

References

  1. Li J, Shen L, Qian K. Global, regional, and national incidence and mortality of neonatal sepsis and other neonatal infections, 1990–2019. Front Public Health. 2023; 11:1139832. https://doi.org/10.3389/fpubh.2023.1139832
     [Google Scholar]
  2. Hammoud MS, Al-Taiar A, Al-Abdi SY, Bozaid H, Khan A, AlMuhairi LM, et al.. Culture-proven early-onset neonatal sepsis in Arab states in the Gulf region: Two-year prospective study. Int J Infect Dis. 2017; 55:11–15. https://doi.org/10.1016/j.ijid.2016.12.006
     [Google Scholar]
  3. Hammoud MS, Al-Taiar A, Thalib L, Al-Sweih N, Pathan S, Isaacs D. Incidence, aetiology and resistance of late-onset neonatal sepsis: A five-year prospective study. J Paediatr Child Health. 2012; 48:(7):604–9. https://doi.org/10.1111/j.1440-1754.2012.02432.x
     [Google Scholar]
  4. GBD 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017; 390:(10100):1151–210. https://doi.org/10.1016/S0140-6736(17)32152-9
     [Google Scholar]
  5. Liu L, Oza S, Hogan D, Perin J, Rudan I, Lawn JE, et al.. Global, regional, and national causes of child mortality in 2000–2013, with projections to inform post-2015 priorities: An updated systematic analysis. Lancet. 2015; 385:(9966):430–40. https://doi.org/10.1016/S0140-6736(14)61698-6
     [Google Scholar]
  6. Rasyida IA, Pratama DC, Chamida FM. Prognostic factors of neonatal sepsis mortality in developing country. Pediatr Infect Vaccine. 2023; 30:(1):12–9. https://doi.org/10.14776/piv.2023.30.e6
     [Google Scholar]
  7. Yusef D, Shalakhti T, Awad S, Algharaibeh Ha, Khasawneh W. Clinical characteristics and epidemiology of sepsis in the neonatal intensive care unit in the era of multi-drug resistant organisms: A retrospective review. Pediatr Neonatol. 2018; 59:(1):35–41. https://doi.org/10.1016/j.pedneo.2017.06.001
     [Google Scholar]
  8. Wei H-M, Hsu Y-L, Lin H-C, Hsieh T-H, Yen T-Y, Lin H-C, et al.. Multidrug-resistant Acinetobacter baumannii infection among neonates in a neonatal intensive care unit at a medical center in central Taiwan. J Microbiol Immunol Infect. 2015; 48:(5):531–9. https://doi.org/10.1016/j.jmii.2014.08.025
     [Google Scholar]
  9. Afsharpaiman S, Torkaman M, Saburi A, Farzaampur A, Amirsalari S, Kavehmanesh Z. Trends in incidence of neonatal sepsis and antibiotic susceptibility of causative agents in two neonatal intensive care units in Tehran, I.R Iran. J Clin Neonatol. 2012; 1:(3):124–30. https://doi.org/10.4103/2249-4847.101692
     [Google Scholar]
  10. Khalil N, Blunt HB, Li Z, Hartman T. Neonatal early onset sepsis in Middle Eastern countries: A systematic review. Arch Dis Child. 2020; 105:(7):639–47. https://doi.org/10.1136/archdischild-2019-317110
     [Google Scholar]
  11. McPheeters ML, Kripalani S, Peterson NB, Idowu RT, Jerome RN, Potter SA, et al.. Closing the quality gap: Revisiting the state of the science (vol. 3: quality improvement interventions to address health disparities). Evid Rep Technol Assess (Full Rep.). 2012 (208.3):1–475.
    [Google Scholar]
  12. Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, et al.. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. OttawaOttawa Hospital Research Institute;n.d. https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
     [Google Scholar]
  13. Fattah MA, Omer AFA, Asaif S, Manlulu R, Karar T, Ahmed A, et al.. Utility of cytokine, adhesion molecule and acute phase proteins in early diagnosis of neonatal sepsis. J Nat Sc Biol Med. 2017; 8:(1):32–9. https://doi.org/10.4103/0976-9668.198362
     [Google Scholar]
  14. Alrafiaah A, AlShaalan M, Alshammari F, Almohaisani A, Bawazir A, Omair A. Neonatal sepsis in a tertiary care hospital in Saudi Arabia. Int J Adv Res. 2016; 4:(11):1713–20. https://doi.org/10.21474/IJAR01/2265
     [Google Scholar]
  15. Mubaraki MA, Faqihi A, AlQhtani F, Hafiz TA, Alalhareth A, Thagfan FA, et al.. Blood biomarkers of neonatal sepsis with special emphasis on the monocyte distribution width value as an early sepsis index. Medicina (Kaunas). 2023; 59:(8):1425. https://doi.org/10.3390/medicina59081425
     [Google Scholar]
  16. Al-Zahrani AK, Ghonaim MM, Hussein YM, Eed EM, Khalifa AS, Dorgham LS. Evaluation of recent methods versus conventional methods for diagnosis of early-onset neonatal sepsis. J Infect Dev Ctries. 2015; 9:(4):388–93. https://doi.org/10.3855/jidc.5950
     [Google Scholar]
  17. Al Mannaei L, Al-Saad IY, Al Saadon E. Neonatal sepsis: A two-year review of the antibiograms of clinical isolates from the neonatal unit. Bahrain Med Bull. 2017; 39:(2):78–81.
    [Google Scholar]
  18. Alarjani KM, Almutairi AM, AlQahtany FS, Soundharrajan I. Methicillin and multidrug resistant pathogenic Staphylococcus aureus associated sepsis in hospitalized neonatal infections and antibiotic susceptibility. J Infect Public Health. 2021; 14:(11):1630–4. https://doi.org/10.1016/j.jiph.2021.08.031
     [Google Scholar]
  19. Hammoud MS, Al-Taiar A, Al-Abdi SY, Bozaid H, Khan A, AlMuhairi LM, et al.. Late-onset neonatal sepsis in Arab states in the Gulf region: Two-year prospective study. Int J Infect Dis. 2017; 55:125–30. https://doi.org/10.1016/j.ijid.2017.01.006
     [Google Scholar]
  20. Almudeer AH, Alibrahim MA, Gosadi IM. Epidemiology and risk factors associated with early onset neonatal sepsis in the south of KSA. J Taibah Univ Med Sci. 2020; 15:(6):509–14. https://doi.org/10.1016/j.jtumed.2020.08.009
     [Google Scholar]
  21. Vellamgot AP, Salameh K, Habboub LHM, Pattuvalappil R, Elkabir NA, Siam YS, et al.. Suspected clinical chorioamnionitis with peak intrapartum temperature <380C: The prevalence of confirmed chorioamnionitis and short term neonatal outcome. BMC Pediatrics. 2022; 22:(1):197. https://doi.org/10.1186/s12887-022-03239-9
     [Google Scholar]
  22. Al-Mouqdad MM, Egunsola O, Ali S, Asfour SS. A neonatal unit experience with empiric antibiotics for late-onset neonatal sepsis: A retrospective study. Pediatr Qual Saf. 2019; 4:(6):e239. https://doi.org/10.1097/pq9.0000000000000239
     [Google Scholar]
  23. Al-Matary A, Al Sulaiman M, Al-Otaiby S, Qaraqei M, Al-Matary M. Association between the timing of antibiotics administration and outcome of neonatal sepsis. J Infect Public Health. 2022; 15:(6):643–7. https://doi.org/10.1016/j.jiph.2022.05.004
     [Google Scholar]
  24. Alharbi AS. Common bacterial isolates associated with neonatal sepsis and their antimicrobial profile: A retrospective study at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Cureus. 2022; 14:(1):e21107. https://doi.org/10.7759/cureus.21107
     [Google Scholar]
  25. Gad A, Khalil A, Halil M, Chandra P, Soliman A, Rahman E’mar A, et al.. Preterm infants with positive conjunctival swab culture: Risk factors and association with late-onset sepsis-A retrospective cohort study. Front Pediatr. 2023; 11:1259558. https://doi.org/10.3389/fped.2023.1259558
     [Google Scholar]
  26. Al-Matary A, Heena H, AlSarheed AS, Ouda W, AlShahrani DA, Wani TA, et al.. Characteristics of neonatal sepsis at a tertiary care hospital in Saudi Arabia. J Infect and Public Health. 2019; 12:(5):666–72. https://doi.org/10.1016/j.jiph.2019.03.007
     [Google Scholar]
  27. Ministry of Health. Protocol for screening and management of suspected neonatal sepsis. RiyadhMinistry of Health;2019. https://publicportal.ksmc.med.sa/en/Document%20library%20backup/Clinical%20Practice%20Guidlines%20and%20Flowcharts/Clinical%20Practice%20Guidelines%20-%20Protocols%20-%20Pathways/Pediatric%20Hospital/Neonatal%20Sepsis/Neonatal%20-Manual%20-%20Revised.pdf
     [Google Scholar]
  28. National Institute for Health and Care Excellence. Neonatal infection: Antibiotics for prevention and treatment. ManchesterNational Institute for Health and Care Excellence;2024. https://www.nice.org.uk/guidance/ng195/chapter/Recommendations#antibiotics-for-late-onset-neonatal-infection
     [Google Scholar]
  29. Coggins SA, Glaser K. Updates in late-onset sepsis: Risk assessment, therapy, and outcomes. Neoreviews. 2022; 23:(11):738–55. https://doi.org/10.1542/neo.23-10-e738
     [Google Scholar]
  30. Abdellatif M, Al-Khabori M, Rahman AU, Khan AA, Al-Farsi A, Ali K. Outcome of late-onset neonatal sepsis at a tertiary hospital in Oman. Oman Med J. 2019; 34:(4):302–7. https://doi.org/10.5001/omj.2019.60
     [Google Scholar]
/content/journals/10.5339/qmj.2024.62
Loading
Bacterial profile and antimicrobial susceptibility patterns of common neonatal sepsis pathogens in Gulf Cooperation Council countries: A systematic review and meta-analysis
Qatar Medical Journal 2024, 62 (2024); https://doi.org/10.5339/qmj.2024.62
/content/journals/10.5339/qmj.2024.62
/content/journals/10.5339/qmj.2024.62
Loading

Data & Media loading...

  • Article Type: Review Article
Keyword(s): antibiotic resistance, bacterial resistance, Bahrain, Gulf Cooperation Council, Kuwait, Neonatal sepsis, newborn sepsis, Oman, Qatar, Saudi Arabia and United Arab Emirates

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error