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Volume 2024, Issue 4
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

Hirsutism is a common endocrine problem with high prevalence in Iraqi women. Polycystic ovarian syndrome and idiopathic hirsutism (IH) are the most common etiology of this disorder. There is a clear association between insulin resistance and polycystic ovarian syndrome. However, there is insufficient data on the relationship between insulin resistance and IH.

The aim of this study was to determine whether Iraqi women with IH have insulin resistance.

The study included two groups: 60 Iraqi women with IH and 60 women without hirsutism as a control group. A physical examination, a medical history, and the patient's age and BMI were collected. Blood samples were collected for hormone analysis, including insulin, follicle-stimulating hormone, luteinizing hormone, prolactin, dehydroepiandrosterone sulfate, 17-hydroxyprogesterone, and free testosterone. To evaluate insulin resistance in both groups, the homeostasis model assessment-insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI) were used in addition to the Matsuda index.

Basal insulin was higher in the IH group (9.5 ± 0.2 mIU/L) than in the control group (4.8 ± 3.7 mIU/L), with a value of < 0.0001. HOMA-IR was higher in the IH group (2.3 ± 4.1 μU mg), while in the control group, it was (0.8 ± 1.2 μU mg), with a value of 0.007. There was a significant difference in the QUICKI, which was lower in the IH group (0.31 ± 0.2 μU-1/mg) than in the control group (0.45 ± 0.1 μU-1/mg), with a value of < 0.0001. The insulin sensitivity index (Matsuda) was significantly lower in the IH group (3.1 ± 0.4) than in the control group (7.8 ± 1.3), with a value of < 0.0001.

According to the results of this study, Iraqi women with IH have insulin resistance and higher basal insulin levels.

© 2024 Alaasam, Al-bdairi, Abboodi, licensee HBKU Press.
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2024-12-21
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/content/journals/10.5339/qmj.2024.72
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Insulin resistance in Iraqi women with idiopathic hirsutism in Najaf City: A case–control study
Qatar Medical Journal 2024, 72 (2024); https://doi.org/10.5339/qmj.2024.72
/content/journals/10.5339/qmj.2024.72
/content/journals/10.5339/qmj.2024.72
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  • Article Type: Research Article
Keyword(s): HOMA-IR, Idiopathic hirsutism, insulin resistance and Iraq

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