Qatar Medical Journal - Volume 2005, Issue 1

An old lady with mitral regurgitation, and chronic atrial fibrillation, who was maintained on amiodarone 200 mg daily for five years, presented with fever and confusion due to septicemia and hepatic encephalopathy. Her chest radiograph and chest CT scan showed interstitial infiltrates. Histopathology of transbronchial biopsies suggested amiodarone-induced lung toxicity. The amiodarone was discontinued and the patient showed some improvement. The case, the presentation and the diagnosis are discussed.

In this article(1), the authors reviewed an interesting topic of which all Radiologists and Surgeons need to be aware. The pathology of the condition was well reviewed as well as the clinical presentation and the management in the four cases presented.

This abstract was presented in 1st Gulf Scientific Dental Meeting inAl Khobar, Saudi Arabia, 30th September, 2004.

Context: There is a paucity of effective, well-tolerated drugs available for migraine prophylaxis.

Objective: To determine whether treatment with the angiotensin II receptor blocker candesartan is effective as a migraine-prophylactic drug.

Design and Setting: Randomized, double-blind, placebo-controlled crossover study performed in a Norwegian neurological outpatient clinic from January 2001 to February 2002.

Patient: Sixty patients aged 18 to 65 years with 2 to 6 migraine attacks per month were recruited mainly from newspaper advertisements.

Interventions: A placebo run-in period of 4 weeks was followed by two 12-week treatment periods separated by 4 weeks of placebo washout. Thirty patients were randomly assigned to receive one 16-mg candesartan cilexetil tablet daily in the first treatment period followed by 1 placebo tablet daily in the second period. The remaining 30 received placebo followed by candesartan.