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Qatar Foundation Annual Research Conference Proceedings Volume 2014 Issue 1
- Conference date: 18-19 Nov 2014
- Location: Qatar National Convention Center (QNCC), Doha, Qatar
- Volume number: 2014
- Published: 18 November 2014
241 - 260 of 480 results
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Gastric Sleeve Surgery Shifts Immunophenotyping Polarization From M1 To M2 With A Shift From Pro-inflammatory To Anti-inflammatory Pattern In Morbid Obese Subjects.
Authors: Nasser Rizk, Moataz Bashah and Amina FadelBackground Obesity is an inflammatory disease associated with immune cell defects. The objective of this study is to characterize the adipose tissue macrophage (ATM) phenotype and function in human omental adipose tissue and peripheral blood in relation to obesity and its changes after gastric sleeve surgery for weight loss. Methods and subjects: Adipose tissue was obtained from morbid obese subjects with BMI > 40 kg Read More
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"novel Genetic Variants May Modify The Clinical Outcome Of The Phospholamban L39x Mutation In Cardiomyopathy Patients"
Background Dilated Cardiomyopathy (DCM) is a leading cause for heart failure characterized by an enlarged ventricular cavity causing systolic dysfunction. Gene mutations are estimated to be the cause in approximately 30-50% of cases, while modifier genes are thought to influence the clinical outcome. Objectives Using a global and unbiased approach: Next Generation Sequencing (NGS), for one of the largest reported c Read More
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Personalized Medicine And Genomic Wide Association Study Based On Innovative Big Data Analytic And Data Mining Paradigm
More LessPersonalized medicine uses information about an individual's genes, proteins, environment, and phenotype data to prevent, diagnose, and treat diseases. In addition, the innovative bio-markers discovery as the key of personalized medicine across multiple tumor types has unlocked new information about cancer biology by providing critical insights to biological, pathogenic and pharmacologic responses to treatment. In th Read More
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Remote Slow Wave Sleep Monitoring Using A Single Electro-oculograph Channel Based System For Use With Insomnia
Authors: Sana Tmar and Beena AhmedBackground and objective: Sleep disorders, such as insomnia can seriously affect an individual's performance and even lead to psychological problems. Diagnosis and treatment of sleep disorders require the collection of subjective and objective measures of sleep structure. Subjective measures are currently collected during face-to-face clinical consultations with a medical practitioner. Objective measures, obtained fro Read More
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Design, Expression And Characterization Of A Single Chain Fragment Variable Anti-mcf-7 Antibody; A Humanized Antibody Derived From Monoclonal Antibody
More LessAbstract AIM: To generate soluble single chain variable fragments (ScFv) of monoclonal antibody recognizing the human breast cancer cell line (MCF7). METHODS: mRNA was isolated from the hybridoma cell line producing C3A8 monoclonal antibody and the cDNAs encoding variable domains of heavy and light chains (VH and VL) of the antibody were amplified Next, the ScFv DNA was ligated into the phagemid vector Read More
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Hyperglycemia Regulates Annexin A2-s100a10 Localization In Endothelial Cells
Authors: Lara Bou Khzam, Katherine Hajjar and Nasrin MesaeliLara Bou Khzam1, Katherine Hajjar2, Nasrin Mesaeli1 1Weill Cornell Medical College in Qatar, Education City, Doha, Qatar and 2Weill Cornell Medical College New York, USA. Diabetic retinopathy (DR) is a leading cause of legal blindness in working-age individuals resulting in disrupted vascular integrity and pathological retinal angiogenesis in both type I and type II diabetes. Annexin A2 is a regulator of endothelial morp Read More
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Changing Nursing Practice
More LessDescription: Clinical nursing practice is on the cusp of significant and unrelenting change amid globalization, austerity measures, and technological advancements as the world moves out of the industrial age into the knowledge age. With advances in technology, theory, and research, the potential changes to future nursing practice are unlimited. Issues such as telehealth, nanotechnology, and globalization are but a few of Read More
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A Novel Homozygous Lrp5 Splice-site Deletion Mutation Causes Syndromic Autosomal Recessive Familial Exudative Vitreoretinopathy.
Authors: Vasiliki Chini, Yasser Al Sarraj, Michael Trese, Hatem El Shanti and Marios KambourisA consanguineous Saudi Arabian family with two female siblings affected by an autosomal recessive condition resembling Familial Exudative Vitreoretinopathy [FEVR], but also with short stature, bone fragility with thin and wasted appearance was studied by homozygosity mapping and positional candidate gene screening to identify the offending gene and mutation. The gene was mapped to three possible homozygous g Read More
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Title: The Use Of Low Intensity Pulsed Ultrasound (lipus) And Gingival Mesenchymal Stem Cells (gmscs) For The Treatment Of Severe Periodontal Defects In Dogs
Authors: Khaled Ataf Abdel-ghaffar, Tarek El-bialy, Ali Saleem, Mamdouh Farid and Elham FawziAbstract: Over the past few years, tissue engineering in dentistry has achieved relevant results. Several methods have been described to enhance tissue engineering and low intensity pulsed ultrasound (LIPUS) has shown to play an important role in tissue formation and regeneration. (LIPUS) can accelerate bone fracture healing and osteogenic differentiation. The aim of this study was to evaluate the effect of local use of autol Read More
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Characterizing The Role Of Fikk Kinases In Toxoplasma Gondii Encystation
Authors: Sini Skariah, Dana Mordue and Ali SultanToxoplasma gondii (Tg), causative agent of the disease toxoplasmosis in humans is an opportunistic pathogen belonging to the phylum Apicomplexa, which includes many medically important pathogens such as Plasmodium. Tg life cycle is characterized by two cysts stages: tissue cysts containing bradyzoites and oocysts. Taken together tissue cysts in contaminated food/water and oocysts shed into the environment Read More
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Hdl Cholesterol Efflux Predicts Graft Failure But Not Cardiovascular And Overall Mortality In Renal Transplant Recipients
Aims. A key function of high-density lipoprotein (HDL) particles in cardiovascular protection is cholesterol efflux, the removal of cholesterol from macrophage foam cells and first step in reverse cholesterol transport. This study prospectively investigated whether HDL cholesterol efflux capacity is associated with cardiovascular mortality, all-cause mortality, and graft failure in renal transplant recipients, patients with accelerated Read More
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Evaluation Of Regenerative Potential Of Pulp -derived Stem Cells And Gingival-derived Stem Cells In The Regeneration Of Periodontal Defects (experimental Study)
Abstract Gingival tissue-derived mesenchymal stem cells (GMSCs) were recently identified and characterized as having multipotential differentiation and immunomodulatory properties in vitro and in vivo, and they represent new postnatal stem cell types for cytotherapy and regenerative medicine. Dental pulp stem cells (DPSCs) have very low morbidity, high efficiency and extensive differentiation ability. This study aimed a Read More
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Building Pharmacy Practice Research Capacity In Hamad Medical Corporation, Qatar
Taking forward the research agenda: assessing the needs of pharmacists employed by Hamad Medical Corporation in Qatar Background and Objective: Traditionally, pharmacists in Qatar have very limited formal training related to research. The aim was to determine the needs of Hamad Medical Corporation (the principal public healthcare provider) pharmacists in relation to research education, training and practice. Settin Read More
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Deciphering The Sources Of Population-wide Variation In The Date Fruit Metabolome
Authors: Ilhame Diboun, Sweety Mathew, Maria Torres, Joel Malek and Karsten SuhreDates are important dietary component in the Arab region. Dates production in Qatar is essential for the country's long term food security plan. In this project, we set to investigate the global sources of variation in the dates metabolome. To this end, fully ripened date samples from 138 different varieties were collected from 14 countries including Morocco, Algeria, Tunisia, Libya, Egypt, Sudan, Jordan, Saudi Arabia, UAE, Read More
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Survey Among Healthcare Professionals On The Implications Of Pharmacogenetics And Its Limitations
Authors: Dania Alkhiyami, Dima Alsahan, Ahmed Abdelbari and Hazem ElewaPharmacists are expected to play an important role in applying pharmacogenetic discoveries to patient care. Despite the increased attention to genetic research in Qatar, clinicians' attitude towards pharmacogenetics' applications are not yet explored. Purpose: To determine the level of awareness, and perceived clinical implications of pharmacogenetics among health care professionals (physicians and pharmacists) in Q Read More
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The Characteristic And Outcome Of Foreign Body (fb) In Children In The State Of Qatar
Background: There are many children who present with a problem of Foreign Body (FB) that can be inserted in different orifices of their body like nose, ears or that are ingested in to their gut or being aspirated to their trachea or bronchioles. FB can be even life threating especially in case of chocking and potential of obstructing child's airway, or ingestion of sharp objects, magnetics, or batteries that may contribute to a lot of Read More
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Linked Data Based Semantically Enabled Electronic Medical Record Systems
More LessElectronic Medical Record (EMR) systems are information systems keeping electronic versions of patients' medical records. The use of EMR systems has been steadily increasing in recent years, due to many potential benefits. A fully functional EMR system can record patient demographic and chart data, keep track of vital signs, current medications, drug allergies and many other important facets of the patie Read More
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Ultrasound Image Enhancement Using An Adaptive Anisotropic Diffusion Filter
Authors: Yassine Toufique and Othmane BouhaliUltrasound imaging system is an important imaging modality for the diagnosis of most pathology. However, in certain situations the accuracy of diagnosis can be altered due to the speckle noise that affects these images, which can lead to a misdiagnosis. Ultrasonic speckle is an interference effect caused by the scattering of the ultrasonic beam from microscopic tissues inhomogeneities. To curb this difficulty many despecklin Read More
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Safety And Efficacy Of Ara 290, A Non-erythropoietic Peptide Engineered From Erythropoietin, In Patients With Painful Diabetic Neuropathy
Human diabetic neuropathy is the commonest long-term complication of diabetes and leads to pain, impotence, foot ulceration and amputation. Currently there are no FDA approved therapies for human diabetic neuropathy. ARA 290 is a novel non-hematopoietic peptide designed from the structure of erythropoietin to preferentially interact with the innate repair receptor that mediates tissue protection and repair. It has sho Read More
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Vitamin D Deficiency Among The Elderly: Insights From Qatar
Background: Vitamin D(VitD) deficiency is associated with co-morbidities in the elderly. VitD deficiency remains an under recognized problem in the general population and is poorly defined in elderly patients. In a geriatric population, VitD deficiency has been associated with poor muscular, physical and cognitive physical performance as well as falls and fractures. VitD deficiency is significantly associated with older age and e Read More
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