- Home
- Conference Proceedings
- Qatar Foundation Annual Research Conference Proceedings
- Conference Proceeding
Qatar Foundation Annual Research Conference Proceedings Volume 2016 Issue 1
- Conference date: 22-23 Mar 2016
- Location: Qatar National Convention Center (QNCC), Doha, Qatar
- Volume number: 2016
- Published: 21 March 2016
301 - 320 of 656 results
-
-
A Dual Role of Il-6 in Bone Marrow and Adipose Tissue-Derived Preadipocyte Differentiation
Introduction Preadipocytes constitute up to 50% of adipose tissue-derived stromal vascular fraction (SVF) and have the ability to differentiate into functional adipocytes in response to nutrient excess and metabolic demand. Impairment of the differentiation of SVF-derived preadipocytes in obesity is associated with increased risk of insulin resistance and type 2 diabetes (Guilherme et al. 2008). Various factors influence prea Read More
-
-
-
Nutritional and Genetic Determinants of Cardiovascular Risk
A population of 503 adult Caucasians was recruited to evaluate the effect of diet on cardiovascular risk factors and its interaction with the genetic background. Nutritional data were collected by 24h recalls and Mediterranean diet adherence was investigated by QuADM-15 questionnaire. Anthropometric measurements (weight, height, and waist circumference), lipid profile, serum glucose, electrolytes, homocysteine and h Read More
-
-
-
Synephrine as Antioxidant: Application in Quenching of Photo Induced Radical of Anthraquinone and Naphthoquinone
Authors: YasserH. A. Hussein, Velautham Sivakumar, Marwa Elazazy and Karuppasamy GaneshPhotosensitive molecules such as quinones in drugs may become activated by exposure to UV-A light (320–400 nm) of the solar spectrum and cause damages to biological materials such as amino acids, nucleic acids, lipids, etc.. 9,10-anthraquinone (AQ) and 1,4-naphthoquinone (NQ), based drugs are commonly used as antibacterial, antifungal, antiviral, antitumor and antimalarial. Synephrine (SY) is used in traditional Read More
-
-
-
Filamin A is Reduced and Contributes to CASR Sensitivity in Human Parathyroid Tumors
Background Parathyroid tumors display reduced sensitivity to extracellular calcium ([Ca2+]o). The parathyroid cell sensitivity to [Ca2+]o is mediated by the calcium-sensing receptor (CASR), a G-protein-coupled receptor interacting with the scaffold protein filamin A (FLNA). We investigated: the FLNA expression in human parathyroid tumors, its effect on the CASR membrane stabilization, and on ERK signaling act Read More
-
-
-
An Experimental Setup for Studying Hemodynamics Through Tissue Engineered Aortic Heart Valves
Authors: Huseyin Cagatay Yalcin and Albert Ryszard LiberskiCalcific aortic valve disease (CAVD) is the most common valvular disorder, affecting approximately 25% of the population aged over 65 years. The formation of calcific nodules on the aortic surface of the leaflets contributes to a progressive obstruction of the left ventricular outflow and leads ultimately to heart failure (Stewart et al., 1997). While CAVD has been described historically as a passive degenerative process, it has no Read More
-
-
-
Obesity in the Qatari Population: An Epidemiological Perspective
Background Obesity is strongly associated with several non-communicable conditions including diabetes, heart disease, hypertension, stroke, and hypercholesterolemia.1 The global frequency of obesity and the metabolic syndrome has increased over the most recent decades and has been linked to an increase in the global burden of disease2. According to the 2012 STEPS survey, 70% of the adult Qatari population is overwe Read More
-
-
-
Embelin-Mediated Apoptosis in Leukemic Cells via Generation of Reactive Oxygen Species
Background The X-linked inhibitor of apoptosis (XIAP) is a promising molecular target for the design of novel anticancer drugs aiming at overcoming apoptosis-resistance of cancer cells. Recent studies demonstrated that the BIR3 domain of XIAP where caspase-9 and Smac proteins bind is an attractive site for designing small-molecule inhibitors of XIAP. Embelin, identified primarily from the Embelica ribes plant, is one such co Read More
-
-
-
Autosomal Dominant Hypocalcemia due to a Truncation in the C-Tail of the Calcium-Sensing Receptor
Background Autosomal Dominant Hypocalcemia (ADH) is an endocrine disorder due to activating mutations of the calcium-sensing receptor (CASR) gene that encodes for a plasma membrane G protein-coupled receptor. This protein plays a central role in maintaining calcium homeostasis. ADH is characterized by hypocalcemia and hypercalciuria with inappropriately low serum concentration of parathyroid hormone (PTH). We rep Read More
-
-
-
Solving All-Pairs Suffix Prefix – Theory and Practice
Authors: Maan Haj Rachid and Qutaibah MalluhiThe overlap stage is one of the most time- and space-consuming steps in de novo genome assembly. The huge size of output of Next Generation Sequencing (NGS), represented by small segments of multiple copies of the original genome, creates a serious computational challenge. The target is to find overlaps between each pair of sequences (reads) in order to build an overlap-based graph which constitutes the input for the a Read More
-
-
-
Exploring Medication Error Causality and Reporting: A Cross Sectional Survey of Hamad Medical Corporation Health Professionals
Introduction Medication errors are a major global issue, adversely impacting patient safety and health outcomes. Promoting patient safety through minimizing medication errors is therefore a key global healthcare objective. The most widely used and accepted definition of the term ‘medication error’ is that of the United States (US) National Coordinating Council for Medication Error Reporting and Prevention (NCCMERP), which d Read More
-
-
-
Analyzing the PharmD Programme at Qatar University (QU) Using the Theoretically Driven Communities of Practice Feamework (CoPF)
More LessBackground Duncan-Hewitt and Austin (2005) argue that pharmacist education has shifted from apprenticeship into higher education. This shift created “a gap between education theory and education practice”. Therefore, the role education theory plays in educational practices should be examined. Objectives Analyze the PharmD programme at QU through the lens of a theory-informed CoPF comprising of six elements: e Read More
-
-
-
Application of Pulsed Streaming Potentials in Plastic Microfluidic Channels for Quantitative Point-of-Care Determination of Cardiac Markers
Authors: Marwa Elazazy and Julio AlvarezAcute myocardial infarction (AMI) is a well-recognized angiocardiopathy that can be spotted by a rise and fall of “chemical biomarkers” in a clinical context. Biomarkers are then, valuable indicators, together with ischemic symptoms, of an impaired cardiac function. Assay of Cardiac troponin T (cTnT), the biomarker of choice, is now an indispensable element in the medical practice followed to diagnose and control AMI. Though Read More
-
-
-
Persistence of Candida Dubliniensis in the Lower Airways of Cystic Fibrosis Patients
Authors: Atqah Abdulwahab, Hussam Salah, Anna Kolecka, Teun Boekhout and Saad J Taj-AldeenBackground Cystic fibrosis (CF) is a genetic disease affecting 70,000 individuals worldwide and results from mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR). In the lungs, the mucociliary clearance mechanism is impaired and the airways of CF patients are often colonized by bacteria, yeasts and filamentous fungi. Among clinically significant fungi, Candida spp. are the most com Read More
-
-
-
Frequency of Clinically Important RH and Kell Blood Group Antigens Among Blood Donors in Qatar
Background Very limited information is available about the prevalence of blood groups among Qatari population and residents. The information about frequencies of different blood group antigens is important to manage, patients who has tendency to develop alloantibodies such as thalassemics. Thalassemia is most common genetically inherited blood disorder due to a quantitative defect in hemoglobin formation, r Read More
-
-
-
The Bacteriophage Efficiency and Antibiotics Susceptibility against Escherichia Coli and Staphylococcus Aureus
More LessIntroduction This study was held on the in vitro tests for the bacteriophages and their efficiency comparing with the antibiotics susceptibility in destroying bacteria. Because the development of the resistance to chemotherapeutic agents is becoming an increasing problem. Antimicrobial phage therapy trials have demonstratedphage infection of the increasing incidence resistantbacteria against most or all known antibioti Read More
-
-
-
Structure, Function and Evolution of Y-Nucleoporins and Eukaryotic Coatomer Components Using Sequence Space Walks and Tissue-Specific Expression Patterns
Authors: Vasilis J. Promponas and Christos A. OuzounisWe developed novel methodological approaches using multi-level data integration bioinformatics techniques to explore the structural, functional and evolutionary relationships of the Y-complex nucleoporins (Y-Nups), essential components of the eukaryotic nuclear pore. Previous evidence suggested that Y-Nups are involved in cellular processes beyond the nuclear pore Y-complex. We obtained all known (1813) and newly di Read More
-
-
-
Design of a Real-Time Epidemic Alert System for Cross Border Disease Control and Epidemic Management
Authors: Francis Enejo Idachaba and Ejura Mercy IdachabaThe key challenge with Epidemics includes its ability to spread rapidly and impact several large communities with high fatality rates. These characteristics make it difficult and very expensive to manage epidemics once it has broken out. History is replete with several cases of epidemic out breaks spreading from the point of origin and being transmitted to other areas resulting in the deaths of several thousands and in so Read More
-
-
-
A Three-Way Decision Making Approach to Protein Functions Classification
Authors: Nouman Azam and Hafeez Ur RehmanIntroduction Proteins are the most important molecules of life that are part of almost every biological process. The knowledge of protein functions plays an essential role in understanding biological cells which ultimately have a significant impact on human life in areas, such as, personalized medicine, better crops and improved therapeutic interventions. The conventional approaches for classifying protein functions are essent Read More
-
-
-
Metformin Mediated Inhibition of the mTOR Pathway Promotes Death in Glucose Starved Micro-Vascular Endothelial Cells
Authors: Samson Mathews Samuel, Suparna Ghosh, Yasser Majeed and Chris R. TriggleBackground & objective In order to survive the effects of the stress conditions, such as hypoxia and glucose starvation (GS) that exist in a tumor microenvironment, the regulatory mechanisms that control metabolism in cancer cells undergo change so that sufficient energy sources are available for proliferation, migration and invasion - thus facilitating metastasis. Via what is referred to as The Warburg Effect cancer cell Read More
-
-
-
Modeling the Best Cleanliness Practices for Qatar Healthcare Establishments
Authors: Mohammed Nishat Faisal and Faisal TalibIn recent years, healthcare has become an important area of concern for both government and private healthcare establishments (HCEs) as are facing challenges in the delivery and provisioning of high quality services to satisfy their patients. However, healthcare not only means saving lives, preventing or relieving sufferings, and curing diseases and disability but providing cleanliness and impeccable hygienic ambience in and Read More
-