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Qatar Foundation Annual Research Forum Volume 2012 Issue 1
- Conference date: 21-23 Oct 2012
- Location: Qatar National Convention Center (QNCC), Doha, Qatar
- Volume number: 2012
- Published: 01 October 2012
121 - 140 of 469 results
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Depot-specific differences in vascular noradrenergic sensitivity in morbidly obese Qataris
Background & Objectives: Expanding adipose tissue in obesity requires effective vasoreactivity to combat hypoxia and its consequences, such as insulin resistance and type 2 diabetes. While recent evidence suggests that the adipose tissue is highly angiogenic, the tissue arteriolar vasoreactivity has been less investigated. Furthermore, the omental adipose tissue (OAT) synthesizes greater levels of vasocontrictive m Read More
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Challenges of reliability testing in Qatar: Patient willingness for participation by mail or in person in a novel research instrument in Doha, Qatar.
Authors: Amal Khidir, Maha Elnashar, Huda Abdelrahim, Maya Hammoud, Humna Asad and Michael FettersBackground: Novel survey instrument development requires reliability testing, but limited information informs the preferred approach in Qatar. The testing of survey characteristics of the Multi-Cultural Assessment Inventory-Qatar (MAI-Q), a novel multicultural assessment tool in Arabic, English, Hindi and Urdu, provided the opportunity to investigate survey distribution procedures. Objective: To determine willingness to participate Read More
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Clinical Research activity in Qatar and the WHO Eastern Mediterranean region: A quantitative analysis.
Authors: Raghib Ali and Abdul Bari BenerBackground and Objectives: Clinical research has led to some of the most important advances in improving human health including the discovery of important risk factors for heart disease, diabetes and cancer as well as treatments for common diseases which have led to unprecedented increases in life expectancy. Unfortunately despite having nearly 600 million people, the Eastern Mediterranean region (EMR) is one of th Read More
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Design of new high resolution quadratic time-frequency distributions for monitoring newborn health outcomes
Authors: Taoufik Ben Jabeur and Boualem BoashashBackground: In order to monitor the health of new borns , high performance sensors are placed on the body to record information from different organs: nervous system (EEG signals), heartbeat and fetal movement (accelerometer signals). As the received data are non-stationary signals, Quadratic Time-frequency distributions (QTFDs) are often used to represent the energy, temporal and spectral characteristics of these s Read More
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Liver image segmentation from CT data
Authors: Sarada Prasad Dakua and Julien Abi-NahedBackground & Objectives Despite its long track record, segmentation in medical image computing still remains an active field of research, largely due to the complexities of in-vivo anatomical structures. We present a novel segmentation algorithm based on chaotic theory; the preliminary results show the potential of the technique. Methods: Henri Poincare first developed (later revisited by Lorentz) this chaotic model by ob Read More
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The development of a set of shared core IPE competencies and evaluation criteria for Qatar: The process and the product
By Brad JohnsonInterprofessional Education (IPE) is defined by the World Health Organization (WHO) as the process by which a group of practicing health-care professionals work together in order to provide promotive, preventive, curative, rehabilitative and other health-related services. WHO strongly encourages efforts to develop and integrate IPE into educational health-care programs for patients' benefits. For this to occur, a set of s Read More
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Does religious fasting in the Islamic holy month of Ramadan predispose to atrial fibrillation? A population-based study
Authors: Amar M Salam, Hajar A AlBinali, Abdul Wahid Al-Mulla, Rajvir Singh and Jassim Al SuwaidiBackground and Objectives: Over one billion Muslims religiously fast worldwide during the month of Ramadan. Fasting during Ramadan is essentially a radical change in lifestyle for the period of one lunar month, so it is important to see whether this change predisposes patients to developing atrial fibrillation (AF). Our objective in this study is to investigate whether Ramadan fasting has any effect on the number of h Read More
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Assessment of ultrasonic-assisted enzymatic digestion of complex protein mixtures by high-resolution mass spectrometry
Authors: Shaima S Dib, Anja M Billing, Shareef J Antar and Johannes GraumannBackground & Objectives Large-scale proteome analysis by mass spectrometry is commonly preceded by enzymatic digestion of proteins. The conventional protocol for in-solution digest of complex protein mixtures includes trypsin and is performed at room temperature for at least 12h. To improve this time-consuming method we assessed the efficiency of focused ultrasound-assisted enzymatic digest. It has previously been Read More
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Uropathogens from Qatari type 2 diabetics with asymptomatic bacteriuria: Antibiotic sensitivity, virulence factors and phylogenetic groups of isolated Escherichia coli
Authors: Nahla Afifi, Asma Al-Thani, Soliman Ewis, Asmaa Abu Abdullah, Haneen Albardawil, Heba Yasin and Wazeera RoubanThe urinary tract infections (UTIs) are among the most common bacterial infections in diabetic patients, especially asymptomatic bacteriuria. The aim of this study is to investigate the causative organisms of ABU in type 2 diabetic patients, the phylogenetic grouping and the antibiotic sensitivity pattern of the causative organism in order to determine the drug of choice to cure ASB in diabetics. One hundred & sixty eight men wer Read More
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Viral etiology of acute gastroenteritis among hospitalized patients in Doha, Qatar: A pilot study
Authors: Asma Althani, Maide Mustafa Yuksel, Said Aldahry and Najah Mohamed Al LawatiIntroduction: Acute gastroenteritis is a widespread disease that is characterized by diarrhea, vomiting and abdominal pain. It has high morbidity and mortality rate globally. Bacteria, parasites and mostly viruses cause acute gastroenteritis. Most frequent viruses are norovirus, adenovirus, astrovirus and rotavirus. Objectives: To determine the prevalence of the four viruses in the stool samples of patients who were treated a Read More
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Phenylephrine induced Na+/H+ exchanger isoform 1 expression modulates cell viability in human embryonic kidney (HEK 293) cells.
Authors: Iman Abdelaziz, Taqdees Mahroof and Fatima MraicheBackground: Na+/H+-exchanger isoform 1 (NHE1) is a ubiquitously expressed housekeeping glycoprotein that functions to regulate intracellular pH. Current reports have suggested that NHE1 is crucial to cell survival in the context of chronic kidney disease. The cellular mechanism by which NHE1 stimulates cell survival requires further investigation. Osteopontin (OPN), is a macrophage chemotactic protein that has been linked to ti Read More
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Automated feature detection on ECG waveforms
Authors: Abdul Jaleel Palliyali, Reza Tafreshi, Nasreen Mohsin and Leyla TafreshiThis work presents the development of an algorithm for analyzing ECG waveforms. The identification of the various waveforms on an ECG is the first and most crucial step in any automated analysis. The algorithm developed is capable of detecting all important waveforms. These include the Q,R,S,R' and S' waves, J and ST points and onset and offset of P and T waves. The various techniques utilized in their detection include a Read More
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Primary coronary intervention for myocardial infarction in Qatar: First nationwide program
We have designed the first nationwide primary percutaneous coronary intervention (PPCI) program for ST elevation myocardial infarction (STEMI) in Qatar. Guidelines emphasize the door to balloon time (DBT) which should not exceed 90 minutes. This interval reflects the efficiency of the hospital system in the rapid recognition and transfer of the STEMI patient to the catheterization laboratory for PPCI. Although DBT is cle Read More
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Think small: The zebrafish as a novel disease model in QCRC
Authors: Magdi Yacoub, Thomas Brand and Jan SchlueterAnimal models are essential to understand the molecular and cellular basis of human pathologies. The zebrafish has gained significant attention as a novel model system and has several advantages over rodent models, including: (1) genetic and physiological similarity to humans, (2) a high fertility rate, (3) external fertilization, (4) ease of genetic manipulation, (5) enlarging library of heart-specific reporter genes, (6) ability to Read More
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Late stimulation of myocardial recovery, following insertion of a continuous flow LVAD
Authors: Magdi Yacoub, Sherif Helmy, Mohamed Al Hashemi, Cesare Terracciano, Michael Ibrahim, Robert Bonow and Amr BadrThe use of mechanical assist devices for the treatment of advanced heart failure has increased dramatically in recent years. Significant recovery of myocardial function following insertion of left ventricular assisted device (LVAD) occurs in a small percentage of patients due to unloading alone. Several strategies for enhancing the degree of recovery using combination therapy have been introduced. Most of these strategies dep Read More
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Investigation of genes that are related to colorectal cancer and liver metastasis
Authors: Hassan Adawn, Rania Georges and Martin R. BergerProgression of colorectal cancer (CRC) culminates in liver metastasis. To identify genes that are involved in the metastatic phenotype, cDNA microarrays were used to analyze mRNA expression profiles of CC531 rat colon adenocarcinoma cells for changes related to their homing into the liver. Briefly, CC531 cells were intraportally implanted into the liver of Wag-Rij rats and re-isolated after 3, 6, 9, 14 and 21 days. Altogeth Read More
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Spatio-temporal characterization of the blood flow in the aortic root
Authors: Magdi Yacoub and Ryo ToriiBackground: The flow profile in the aortic root constitutes a major determinant of coronary and systemic blood flow, depending on the size, shape and dynamism of the aortic root. The aims of this study are to evaluate patterns of flow in the aortic root in health, disease and following different root replacement procedures. Methods: A total of 54 subjects underwent phase-contrast cardiovascular magnetic resonance (PC-CMR). Read More
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Examining secular trends in the utilization of warfarin among Middle Eastern Arab and South Asian patients hospitalized with atrial fibrillation: 20-year experience from Qatar (1991-2010)
Authors: Amar M Salam, Hajar A AlBinali, Abdul Wahid Al-Mulla, Rajvir Singh and Jassim Al SuwaidiObjectives: There is paucity of data relevant to anticoagulation rates and trends of treatment in patients with atrial fibrillation (AF) in developing countries and whether there are ethnic differences in the utilization of warfarin as some reports have suggested. The aim of this study is to evaluate trends of utilization of warfarin in Arab and South Asian patients hospitalized with AF in a real-world population in a Middle East Read More
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An echocardiographic screening of school children for rheumatic heart disease in Aswan, Egypt
Authors: Magdi Yacoub and Susie KotitIntroduction: The global burden of rheumatic heart disease continues to be extremely high, with the main brunt being borne by developing countries. However, the prevalence and disease characteristics vary widely in different populations. Egypt hosts 80 million individuals and is known to be endemic for rheumatic heart disease. Methods: Cross sectional screening of a cohort of randomly selected 3062 school children b Read More
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Characterization of wall biomechanics of the pulmonary autograft after the Ross procedure
Authors: Magdi Yacoub, Ryo Torii and Michael IbrahimBackground: There is continuing concern about the risk of long-term autograft dilatation and rupture following the Ross procedure. The aim of this study is to characterize the neo-aortic valve in terms of morphology and wall distensibility. Methods: Among 108 Ross patients undergoing yearly echocardiographic assessment in our unit, 17 (16%) had aortic root diameters of >45mm (DG) 14 ± 1 years after operation. In an atte Read More
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