Qatar Foundation Annual Research Forum Volume 2013 Issue 1

Mechanism of regulation of extracellular matrix upon endoplasmic reticulum stress

Nanotechnology approaches to the treatment of pulmonary hypertension: Gold nanoparticles and NO-release

Spontaneous abortion affects one in four of all pregnancies (Crenin, 2001). The rate of spontaneous abortion among Qatari Arab women presenting to Women's Hospital, Doha, Qatar is 34% (Women's Hospital, 2012) compared to the next highest ethnic minority (Egyptian Arab women) at 18%. Understanding and modifying risk factors for spontaneous abortion may prevent future miscarriages. Purpose: To assess the level of kno Read More

Background and Objectives: Monoamine oxidase (MAO) catalyzes the biodegradation of biogenic amine neurotransmitters and a variety of xenobiotic amines. Selective MAO B inhibitors are used in the treatment of Parkinson's disease and other neurodegenerative diseases while selective MAO A inhibitors are known antidepressants. Piperazine and pyrazole rings are common moieties in several MAO inhibitors. Th Read More

BACKGROUND: Breast cancer is the most common cancer contributing to morbidity and mortality among Arabic women in Qatar. Arabic women are at risk primarily due to their low participation rates in breast cancer screening practices and subsequent delayed diagnosis of the disease. Therefore, there must be a strong emphasis on the health care providers and the health care system to increase efforts in early detecti Read More

Background and Objectives: The development of athlete-specific hematological reference ranges are essential for sports physicians in the diagnosis of pathologies. Due to unique genetics and training modalities, athletes are known to have atypical hematologic profiles in comparison to the general population and between ethnic groups. The aims of this study were 1) to develop athlete-specific reference ranges and 2) to de Read More

Background: Oncogenic activation of the RAS/RAF signaling pathway induces resistance to anti-epidermal growth factor receptor targeted therapies in patients with colorectal cancer. We investigated the occurrence of BRAF exon 15 and KRAS codons 12 and 13 mutations in patients with colorectal cancer. Patients and Methods: Forty-seven samples from patients with metastasic colorectal adenocarcinomas were studied f Read More

Acidizing core flooding experiments in carbonates are typically performed in the laboratory in order to observe different physical phenomena and to design acid stimulation jobs in the field. The experiments are usually well defined in terms of mineralogy, permeability, porosity, pressure, temperature and salinity. During the tests, key parameters are analyzed such as the pore volume of acid needed to create wormholes a Read More

The rapidly developing infrastructure in Qatar requires an increasing supply of quality construction materials. Qatar has limited resources of quality natural aggregate and has to import coarse aggregate for use in asphalt and concrete applications. At the same time, vast quantities of alternative and recycled aggregates are available with limited use in the construction industry. The innovative use of recycled aggregate in construc Read More