1887
  1. الرئيسية
  2. A-Z Publications
  3. Journal of Emergency Medicine, Trauma and Acute Care
  4. المجلد 2021, العدد 3
  5. المقالة
Volume 2021, Issue 3
  • ISSN: 1999-7086
  • E-ISSN: 1999-7094

ملخص

Inflammation and pain are normally present concomitantly, which requires using a combination of anti-inflammatory and pain killer medications. This could potentially decrease patient adherence to such combinations. Therefore, there is an urgent need to develop combinations of anti-inflammatory and analgesic therapies. This study is designed to evaluate the analgesic and anti-inflammatory activities of a newly synthetic compound of ibuprofen and gabapentin. The study protocol includes two stages. The first stage: the evaluation of the analgesic effectiveness of tested compounds via using hot plate and acetic acid induced-writhing tests. The second stage: the investigation of the anti-inflammatory activity via using dextran induced- peritonitis, cotton pelt induced- granulomas, and formalin induced- paw edema analyses. Rats were randomly divided into four groups (six rats in each group): Group A (control): rats were orally treated with vehicle (propylene glycol 50 % v/v); Group B: rats were orally treated with ibuprofen (10 mg/ kg); Group C: rats were orally treated with gabapentin (200 mg/ kg); and Group D: rats were orally treated with the synthetic compound (ibuprofen-gabapentin) in dose equivalent to 10 mg/ kg ibuprofen and 200 mg/kg gabapentin. It was found that the newly synthesized compound of ibuprofen and gabapentin has significantly reduced the pain in comparison with control groups. Additionally, this compound has significant anti-inflammatory properties compared to medications admitted to the control group as well. The newly synthesized compound (ibuprofen-gabapentin) demonstrates remarkable analgesic and anti-inflammatory activities in comparison with the conventional compounds.

© 2021 Ibrahim, Alsaad, Al-Darraji, Mahdi, licensee HBKU Press.
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/content/journals/10.5339/jemtac.2021.24
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A newly synthetic compound of Ibuprofen and Gabapentin as a novel analgesic and anti-inflammatory therapeutic agent: A pharmacological study in rats’ experimental models
Journal of Emergency Medicine, Trauma and Acute Care 2021, 24 (٢٠٢١); https://doi.org/10.5339/jemtac.2021.24
/content/journals/10.5339/jemtac.2021.24
/content/journals/10.5339/jemtac.2021.24
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الموضوعات الرئيسية analgesic, anti-inflammatory, gabapentin, ibuprofen and novel ibuprofen and gabapentin compound

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