1887
  1. الرئيسية
  2. A-Z Publications
  3. Journal of Emergency Medicine, Trauma and Acute Care
  4. المجلد 2023, العدد 1
  5. المقالة
Volume 2023, Issue 1
  • ISSN: 1999-7086
  • E-ISSN: 1999-7094

ملخص

The COVID-19 pandemic has impacted patient and safety issues globally, with special reference to device-associated infection in critical care patients.

To describe the incidence of device-associated infections, non-device-associated respiratory tract infections (RTIs), and antimicrobial use in critical COVID-19 patients during the first six months of the pandemic.

An observational study was conducted in an intensive care unit of a COVID-19-dedicated facility in Western Qatar from April 1 to September 30, 2020. Healthcare-associated infections (HAIs) were confirmed using the CDC definitions as per the corporate infection control program, except for other RTIs. Antimicrobial consumption was registered as days of therapy.

During the study period, 30 patients (10.9%) with HAIs were reported from 275 patients admitted. Patients with HAI had a higher median Charlson index, hospital stay, mortality, and APACHE II score on admission. The use of devices (central and peripheral lines, urinary catheters, and ventilators) was more frequent in patients with HAI. The RTI (16 cases) and ventilator-associated pneumonia (VAP) (10 cases) were the most frequent localizations. The infection rate for device-associated infections was 7.84, 3.23, and 2.75 per 1000 device days for VAP, central line-associated bloodstream infection, and catheter-associated urinary tract infection, respectively. 49 isolates related to HAI were identified, with 20 isolates being multidrug-resistant organisms (40.8%). A longer duration of antibiotic therapy was observed in HAI patients (34.1 days versus 9.39 days).

The study provides evidence of the impact of COVID-19 on the incidence of device-associated infections in critically ill patients, antibiotics consumption, and antimicrobial resistance.

© 2022 Garcell, Jimenez, de la Nuez Jimenez, Rivera, Abdi, licensee HBKU Press.
Loading

جارٍ تحميل قياسات المقالة...

/content/journals/10.5339/jemtac.2023.6
٢٠٢٣-٠١-٢٠
٢٠٢٤-١١-٠٨
Loading full text...

Full text loading...

/deliver/fulltext/jemtac/2023/1/jemtac.2023.6.html?itemId=/content/journals/10.5339/jemtac.2023.6&mimeType=html&fmt=ahah

References

  1. McMullen KM, Smith BA, Rebmann T. Impact of SARS-CoV-2 on hospital acquired infection rates in the United States: Predictions and early results. Am J Infect Control. 2020 Nov; 48:(11):1409–11. doi: 10.1016/j.ajic.2020.06.209.
     [Google الباحث العلمي]
  2. Baccolini V, Migliara G, Isonne C, Dorelli B, Barone LC, Giannini D, et al. The impact of the COVID-19 pandemic on healthcare-associated infections in intensive care unit patients: a retrospective cohort study. Antimicrob Resist Infect Control. 2021 Jun; 10:(1):87. doi: 10.1186/s13756-021-00959-y.
     [Google الباحث العلمي]
  3. Gómez-Ochoa SA, Franco OH, Rojas LZ, Raguindin PF, Roa-Díaz ZM, Wyssmann BM, et al. COVID-19 in health-care workers: A living systematic review and meta-analysis of prevalence, risk factors, clinical characteristics, and outcomes. Am J Epidemiol. 2021 Jan; 190:(1):161–75. doi: 10.1093/aje/kwaa191.
     [Google الباحث العلمي]
  4. Weiner-Lastinger LM, Pattabiraman V, Konnor RY, Patel PR, Wong E, Xu SY, et al. The impact of coronavirus disease 2019 (COVID-19) on healthcare-associated infections in 2020: A summary of data reported to the National Healthcare Safety Network. Infect Control Hosp Epidemiol. 2022 Jan; 43:(1):1–14. doi: 10.1017/ice.2021.362.
     [Google الباحث العلمي]
  5. Baker MA, Sands KE, Huang SS, Kleinman K, Septimus EJ, Varma N, et al. CDC Prevention Epicenters Program. The impact of COVID-19 on healthcare-associated infections. Clin Infect Dis. 2022 May; 74:(10):1748–54. doi: 10.1093/cid/ciab688.
     [Google الباحث العلمي]
  6. Fakih MG, Bufalino A, Sturm L, Huang RH, Ottenbacher A, Saake K, et al. Coronavirus disease 2019 (COVID-19) pandemic, central-line-associated bloodstream infection (CLABSI), and catheter-associated urinary tract infection (CAUTI): The urgent need to refocus on hardwiring prevention efforts. Infect Control Hosp Epidemiol. 2022 Jan; 43:(1):26–31. doi: 10.1017/ice.2021.70.
     [Google الباحث العلمي]
  7. Bardi T, Pintado V, Gomez-Rojo M, Escudero-Sanchez R, Azzam Lopez A, Diez-Remesal Y, et al. Nosocomial infections associated to COVID-19 in the intensive care unit: clinical characteristics and outcome. Eur J Clin Microbiol Infect Dis. 2021 Mar; 40:(3):495–502. doi: 10.1007/s10096-020-04142-w.
     [Google الباحث العلمي]
  8. Garcia-Vidal C, Sanjuan G, Moreno-García E, Puerta-Alcalde P, Garcia-Pouton N, Chumbita M, et al. COVID-19 Researchers Group. Incidence of co-infections and superinfections in hospitalized patients with COVID-19: a retrospective cohort study. Clin Microbiol Infect. 2021 Jan; 27:(1):83–8. doi: 10.1016/j.cmi.2020.07.041.
     [Google الباحث العلمي]
  9. Baddley JW, Thompson GR 3rd, Chen SC, White PL, Johnson MD, Nguyen MH, et al. Coronavirus disease 2019-associated invasive fungal infection. Open Forum Infect Dis. 2021 Nov; 8:(12):ofab510. doi: 10.1093/ofid/ofab510.
     [Google الباحث العلمي]
  10. Intra J, Sarto C, Beck E, Tiberti N, Leoni V, Brambilla P. Bacterial and fungal colonization of the respiratory tract in COVID-19 patients should not be neglected. Am J Infect Control. 2020 Sep; 48:(9): 1130–1. doi: 10.1016/j.ajic.2020.06.185.
     [Google الباحث العلمي]
  11. Hulkoti VS, Acharya S, Kumar S, Talwar D, Khanna S, Annadatha A, et al. Association of serum ferritin with COVID-19 in a cross-sectional study of 200 intensive care unit patients in a rural hospital: Is ferritin the forgotten biomarker of mortality in severe COVID-19? J Family Med Prim Care. 2022; 11::2045–50.
     [Google الباحث العلمي]
  12. Hedberg P, Ternhag A, Giske CG, Strålin K, Özenci V, Johansson N, et al. Ventilator-associated lower respiratory tract bacterial infections in COVID-19 compared with non-COVID-19 patients. Crit Care Med. 2022 May; 50:(5):825–36. doi: 10.1097/CCM.0000000000005462.
     [Google الباحث العلمي]
  13. AlAhdal AM, Alsada SA, Alrashed HA, Al Bazroun LI, Alshoaibi A. Impact of the COVID-19 pandemic on levels of device-associated infections and hand hygiene compliance. Cureus. 2022 Apr; 14:(4):e24254. doi: 10.7759/cureus.24254.
     [Google الباحث العلمي]
  14. Grau S, Hernández S, Echeverría-Esnal D, Almendral A, Ferrer R, Limón E, Horcajada JP, Catalan Infection Control and Antimicrobial Stewardship Program (VINCat-PROA). Antimicrobial consumption among 66 acute care hospitals in Catalonia: Impact of the COVID-19 pandemic. Antibiotics (Basel). 2021 Aug; 10:(8):943. doi: 10.3390/antibiotics10080943.
     [Google الباحث العلمي]
  15. Ukuhor HO. The interrelationships between antimicrobial resistance, COVID-19, past, and future pandemics. J Infect Public Health. 2021 Jan; 14:(1):53–60. doi: 10.1016/j.jiph.2020.10.018.
     [Google الباحث العلمي]
  16. Kumar S, Dronamraju S, Acharya S, Jaiswal P, Hulkoti V, Talwar D, et al. COVID-PIRO (Predisposition, Insult, Response, Organ Dysfunction) score: A reliable predictor of outcomes in COVID-19 patients admitted in intensive care unit. Cureus. 2021 Oct; 13:(10):e18960. doi: 10.7759/cureus.18960.
     [Google الباحث العلمي]
  17. CDC/NHSN Surveillance definitions for specific types of infections. In: National Healthcare Safety Network (NHSN) Patient Safety Component Manual. January 2021. Available from: https://www.cdc.gov/nhsn/pdfs/pscmanual/pcsmanual_current.pdf. Access December 18, 2021.
     [Google الباحث العلمي]
  18. Gold MS, Sehayek D, Gabrielli S, Zhang X, McCusker C, Ben-Shoshan M. COVID-19 and comorbidities: a systematic review and meta-analysis. Postgrad Med. 2020 Nov; 132:(8):749–55. doi: 10.1080/00325481.2020.1786964.
     [Google الباحث العلمي]
  19. Zhang H, Zhang Y, Wu J, Li Y, Zhou X, Li X, et al. Risks and features of secondary infections in severe and critical ill COVID-19 patients. Emerg Microbes Infect. 2020 Dec; 9:(1):1958–64. doi: 10.1080/22221751.2020.1812437.
     [Google الباحث العلمي]
  20. Rizk NA, Moghnieh R, Haddad N, Rebeiz MC, Zeenny RM, Hindy JR, et al. Challenges to antimicrobial stewardship in the countries of the Arab league: Concerns of worsening resistance during the COVID-19 pandemic and proposed solutions. Antibiotics (Basel). 2021 Oct; 10:(11):1320. doi: 10.3390/antibiotics10111320.
     [Google الباحث العلمي]
  21. Seaton RA, Gibbons CL, Cooper L, Malcolm W, McKinney R, Dundas S, et al. Survey of antibiotic and antifungal prescribing in patients with suspected and confirmed COVID-19 in Scottish hospitals. J Infect. 2020 Dec; 81:(6):952–60. doi: 10.1016/j.jinf.2020.09.024.
     [Google الباحث العلمي]
/content/journals/10.5339/jemtac.2023.6
Loading
Healthcare-associated infection and antimicrobial consumption in critically ill COVID-19 patients: An observational study
Journal of Emergency Medicine, Trauma and Acute Care 2023, 6 (٢٠٢٣); https://doi.org/10.5339/jemtac.2023.6
/content/journals/10.5339/jemtac.2023.6
/content/journals/10.5339/jemtac.2023.6
Loading

جارٍ تحميل البيانات والوسائط...

الموضوعات الرئيسية antimicrobial consumption, COVID-19, critical care unit, healthcare-associated infection and Qatar

الأكثر اقتباسًا لهذا الشهر Most Cited RSS feed

هذه الخانة مطلوبة
يُرجى إدخال عنوان بريد إلكتروني صالح
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error