1887
  1. الرئيسية
  2. A-Z Publications
  3. Qatar Medical Journal
  4. المجلد 2023, العدد 4
  5. المقالة
Volume 2023, Issue 4
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

ملخص

Background: Critical illness-associated cerebral microbleeds and leukoencephalopathy connected to coronavirus disease 2019 (COVID-19) infection are emerging areas of concern in current medical literature.

Methods: We reviewed cases of patients with COVID-19-associated neurological manifestations to study the prevalence and outcome of such conditions.

Case Series Findings: Our review yielded seven distinct patients. Six exhibited cerebral microbleeds, primarily localized in the juxtacortical white matter and the corpus callosum. In contrast, one individual presented with leukoencephalopathy. Tragically, of these patients, five succumbed to their ailments. One was discharged with mild cognitive impairments, while another underwent a tracheostomy and was subsequently moved to a long-term care establishment.

Conclusion: Our findings underscore the significance of neuro-radiological observations in those grappling with severe manifestations of COVID-19, drawing attention to the possible neurological repercussions of the virus.

© 2023 Safan, Imam, Khatib, Al Wraidat, Altermanini, Al-Mughalles, Al-Assaf, Olish, Elshafei, Nashwan, licensee HBKU Press.
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References

  1. Khatib MY, Peediyakkal MZ, Elshafei MS, Elzeer HS, Ananthegowda DC, Shahen MA, et al.. Comparison of the clinical outcomes of non- invasive ventilation by helmet vs. facemask in patients with acute respiratory distress syndrome. Medicine. 2021; 100:4:e24443.doi: [Crossref].
     https://doi.org/10.1097/MD.0000000000024443 [Google الباحث العلمي]
  2. Lai C-C, Shih T, Ko W, Tang H, Hsueh P. Severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int J Antimicrob Agents. 2020; 55:3:105924.doi: [Crossref].
     https://doi.org/10.1016/j.ijantimicag.2020.105924 [Google الباحث العلمي]
  3. Chemaitelly H, Ayoub HH, Faust JS, Coyle P, Tang P, Hasan M, et al.. A turning point in COVID-19 severity and fatality during the pandemic: A national cohort study in Qatar. medRxiv [preprint]. 2023doi: [Crossref].
     https://doi.org/10.1101/2023.05.28.23290641 [Google الباحث العلمي]
  4. Haider A, Siddiqa A, Ali N, Dhallu M. COVID-19 and the brain: Acute encephalitis as a clinical manifestation. Cureus. 2020Oct; 12:10:e10784.doi: [Crossref].
     https://doi.org/10.7759/cureus.10784 [Google الباحث العلمي]
  5. Khurshid A, Khurshid M, Sohail A, Raza IM, Ahsan MK, Alam Shah MUF, et al.. Facial palsy as a manifestation of COVID-19: A systematic review of cases. Health Sci Rep. 2022; 5:6:e887.doi: [Crossref].
     https://doi.org/10.1002/hsr2.887 [Google الباحث العلمي]
  6. Niazkar HR, Zibaee B, Nasimi A, Bahri N. The neurological manifestations of COVID-19: A review article. Neurol Sci. 2020; 41:7:1667–71.doi: [Crossref].
     https://doi.org/10.1007/s10072-020-04486-3 [Google الباحث العلمي]
  7. Ahmed MU, Hanif M, Ali MJ, Haider MA, Kherani D, Memon GM, et al.. Neurological manifestations of COVID-19 (SARS-CoV-2): A review. Front Neurol. 2020May; 11::518.doi: [Crossref].
     https://doi.org/10.3389/fneur.2020.00518 [Google الباحث العلمي]
  8. Nepal G, Rehrig JH, Shrestha GS, Shing YK, Yadav JK, Ojha R, et al.. Neurological manifestations of COVID-19: A systematic review. Crit Care. 2020Jul; 24::421.doi: [Crossref].
     https://doi.org/10.1186/s13054-020-03121-z [Google الباحث العلمي]
  9. Varatharaj A, Thomas N, Ellul MA, Davies NWS, Pollak TA, Tenorio EL, et al.. Neurological and neuropsychiatric complications of COVID-19 in 153 patients: A UK-wide surveillance study. Lancet Psychiatry. 2020Oct; 7:10:875–82.doi: [Crossref].
     https://doi.org/10.1016/S2215-0366(20)30287-X [Google الباحث العلمي]
  10. Ellul MA, Benjamin L, Singh BD, Lant S, Michael B, Easton A, et al.. Neurological associations of COVID-19. Lancet Neurol. 2020Sep; 19:9:767–83.doi: [Crossref].
     https://doi.org/10.1016/S1474-4422(20)30221-0 [Google الباحث العلمي]
  11. Fanou EM, Coutinho J, Shannon P, Kiehl TR, Levi MM, Wilcox ME, et al.. Critical illness–associated cerebral microbleeds. Stroke. 2017Apr; 48:4:1085–7.doi: [Crossref].
     https://doi.org/10.1161/STROKEAHA.116.016289 [Google الباحث العلمي]
  12. Meshref M, Hewila IM, Khlidj Y, Korissi R, Shaheen N, Nashwan AJ, et al.. COVID-19- associated cerebrovascular events: A case series study and a literature review of possible mechanisms. Case Rep Neurol. 2023Feb; 15:1:11–23.doi: [Crossref].
     https://doi.org/10.1159/000529122 [Google الباحث العلمي]
  13. Vattoth S, Abdelhady M, Alsoub H, Own A, Elsotouhy A. Critical illness-associated cerebral microbleeds in COVID-19. Neuroradiol J. 2020; 33:5:374–6.doi: [Crossref].
     https://doi.org/10.1177/1971400920939229 [Google الباحث العلمي]
  14. Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, et al.. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020; 87::18–22.doi: [Crossref].
     https://doi.org/10.1016/j.bbi.2020.03.031 [Google الباحث العلمي]
  15. Ippolito A, Urban H, Ghoroghi K, Rosbach N, Lingwal N, Adam EH, et al.. Prevalence of acute neurological complications and pathological neuroimaging findings in critically ill COVID-19 patients with and without VV-ECMO treatment. Sci Rep. 2022Oct; 12:1:17423.doi: [Crossref].
     https://doi.org/10.1038/s41598-022-21475-y [Google الباحث العلمي]
  16. Chin KS, Hijazi Z, Churilov L, Gajamange S, Desmond PM, Villemagne V, et al.. Cerebral microbleeds in dementia with Lewy bodies. Parkins Related Disord. 2022Nov; 104::68–71.doi: [Crossref].
     https://doi.org/10.1016/j.parkreldis.2022.10.009 [Google الباحث العلمي]
  17. Toeback J, Depoortere SD, Vermassen J, Vereecke EL, Van Driessche V, Hemelsoet DM. Microbleed patterns in critical illness and COVID-19. Clin Neurol Neurosurg. 2021Apr; 203::106594doi: [Crossref].
     https://doi.org/10.1016/j.clineuro.2021.106594 [Google الباحث العلمي]
  18. Venkatesan A, Tunkel AR, Bloch KC, Lauring AS, Sejvar J, Bitnun A, et al.. Case definitions, diagnostic algorithms, and priorities in encephalitis: Consensus statement of the international encephalitis consortium. Clin Infect Dis. 2013Oct; 57:8:1114–28.doi: [Crossref].
     https://doi.org/10.1093/cid/cit458 [Google الباحث العلمي]
  19. Lersy F, Willaume T, Brisset JC, Collange O, Helms J, Schneider F. Critical illness-associated cerebral microbleeds for patients with severe COVID-19: Etiologic hypotheses. J Neurol. 2021Aug; 268:8:2676–84.doi: [Crossref].
     https://doi.org/10.1007/s00415-020-10313-8 [Google الباحث العلمي]
  20. Cooper N, Morrison MA, Vladescu C, Hart ACJ, Paul D, Malik A, et al.. Identification of occult cerebral microbleeds in adults with immune thrombocytopenia. Blood. 2020; 136:25:2875–80.doi: [Crossref].
     https://doi.org/10.1182/blood.2020004858 [Google الباحث العلمي]
  21. Legriel S, Badenes R, Engrand N, Mendoza-Trujillo R, Soulier P, Benghanem S, et al.. Outcomes in patients with COVID-19 with acute encephalopathy and coma: An international prospective study. Neurology. 2023May30; 100:22:e2247–58.doi: [Crossref].
     https://doi.org/10.1212/WNL.0000000000207263 [Google الباحث العلمي]
  22. Dravid A, Kashiva R, Khan Z, Memon D, Kodre A, Potdar P, et al.. Combination therapy of Tocilizumab and steroid for management of COVID-19 associated cytokine release syndrome: A single center experience from Pune, Western India. Medicine. 2021; 100:29:e26705.doi: [Crossref].
     https://doi.org/10.1097/MD.0000000000026705 [Google الباحث العلمي]
  23. Muccioli L, Pensato U, Cani I, Guerra L, Provini F, Bordin G, et al.. COVID-19-related encephalopathy presenting with aphasia resolving following tocilizumab treatment. J Neuroimmunol. 2020; 349::577400.doi: [Crossref].
     https://doi.org/10.1016/j.jneuroim.2020.577400 [Google الباحث العلمي]
/content/journals/10.5339/qmj.2023.29
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COVID-19-associated neurological sequelae: A case series on cerebral microbleeds and encephalopathy
Qatar Medical Journal 2023, 29 (٢٠٢٤); https://doi.org/10.5339/qmj.2023.29
/content/journals/10.5339/qmj.2023.29
/content/journals/10.5339/qmj.2023.29
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  • نوع المستند: Case Report
الموضوعات الرئيسية case series, COVID-19, critical illness microbleeds, encephalopathy and SARS-CoV-2

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