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Volume 2025, Issue 1
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

Pertussis, a highly contagious disease, has made a resurgence following the easing of COVID-19 pandemic restrictions. Infants under three months old are particularly vulnerable due to their immature immune systems and lack of protective vaccination.

This study presents a case series of four infants, aged one to three months, who initially presented with nonspecific respiratory symptoms at Alkhor Hospital between January and June 2024. Subsequent diagnostic testing confirmed pertussis in all four cases. It is noteworthy that all cases involved were previously healthy infants with no underlying health conditions. Additionally, none of the mothers had received the Tdap vaccine during pregnancy.

All infants required hospitalization, with one being admitted to the PICU for eight days. Ultimately, all four infants made a full recovery.

Pertussis remains a significant cause of morbidity and mortality in infants under three months of age. Given the potential for severe complications and the burden it places on the healthcare system during outbreaks, it is crucial to emphasize preventive measures such as maternal vaccination.

© 2025 Alesali, Elhamidi, licensee HBKU Press.
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2025-03-17
2025-04-10
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References

  1. Lauria Ashley M, Zabbo CP. Pertussis. 7 October 2022. In: StatPearls [online]. Treasure Island: StatPearls Publishing; 2024 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK519008/.
     [Google Scholar]
  2. Mattoo S, Cherry JD. Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. Clin Microbiol Rev. 2005Apr; 18:(2):326–82. doi: 10.1128/CMR.18.2.326-382.2005.
     [Google Scholar]
  3. Gendrel D, Raymond J. La coqueluche dans le monde. Vacciner l'enfant et l'adulte. Med Trop Sante Int. 2023 Nov 22; 3:(4):mtsi.v3i4.2023.446. [Article in French] doi: 10.48327/mtsi.v3i4.2023.446.
     [Google Scholar]
  4. Tessier E, Campbell H, Ribeiro S, Rai Y, Burton S, Roy P, et al. Impact of the COVID-19 pandemic on Bordetella pertussis infections in EnglandBMC Public Health. 2022 Feb 28; 22:(1):405. doi: 10.1186/s12889-022-12830-9.
     [Google Scholar]
  5. Matczak S, Levy C, Fortas C, Cohen JF, Béchet S, Belghiti FA, et al. Association between the COVID-19 pandemic and pertussis derived from multiple nationwide data sources, France, 2013 to 2020. Euro Surveill. 2022Jun; 27:(25):2100933. doi: 10.28071560-7917.ES.2022.27.25.2100933.
     [Google Scholar]
  6. Falkenstein-Hagander K, Appelqvist E, Frisk Cavefors AS, Källberg H, Nilsson LJ, Silfverdal S-A. Waning infant pertussis during COVID-19 pandemic. Arch Dis Child. 2022; 107:(3):e19. doi: 10.1136/archdischild-2021-323055.
     [Google Scholar]
  7. Feinmann J. Analysis reveals global post-covid surge in infectious diseases. BMJ. 2024 Jun 18;385:q1348. doi: 10.1136/bmj.q1348.
     [Google Scholar]
  8. Kandeil W, van den Ende C, Bunge EM, Jenkins VA, Ceregido MA, Guignard A, et al. A systematic review of the burden of pertussis disease in infants and the effectiveness of maternal immunization against pertussis. Expert Rev Vaccines. 2020Jul; 19:(7):621–38. doi: 10.1080/14760584.2020.1791092.
     [Google Scholar]
  9. Nieves DJ, Singh J, Ashouri N, McGuire T, Adler-Shohet FC, Arrieta AC. Clinical and laboratory features of pertussis in infants at the onset of a California epidemic. J Pediatr. 2011Dec; 159:(6):1044–6. doi: 10.1016/j.jpeds.2011.08.010.
     [Google Scholar]
  10. Carbonetti NH. Pertussis leukocytosis: mechanisms, clinical relevance and treatment. Pathog Dis. 2016 Oct; 74:(7):ftw087. doi: 10.1093/femspd/ftw087.
     [Google Scholar]
  11. Laboratory testing for pertussis [online]. Centers for Disease Control and Prevention, Centers for Disease Control and Prevention. Available from: www.cdc.gov/pertussis/php/laboratories/ [Accessed 15 August 2024].
  12. Best practices for use of polymerase chain reaction for diagnosing pertussis. Centers for Disease Control and Prevention [online]. Available from: www.cdc.gov/pertussis/php/pcr-bestpractices/ [Accessed 15 August 2024].
  13. van de Zee A, Schellekens JFP, Mooi FR. Laboratory diagnosis of pertussis. Clin Microbiol Rev. 2015 Sep 9; 28:(4):1005–26. doi: 10.1128/CMR.00031-15.
     [Google Scholar]
  14. Gökçe Ş, Kurugöl Z, Aydemir SŞ, Çiçek C, Aslan A, Koturoğlu G. Bordetella Pertussis infection in hospitalized infants with acute bronchiolitis. Indian J Pediatr. 2017 Oct 27; 85:(3):189–93. doi: 10.1007/s12098-017-2480-4.
     [Google Scholar]
  15. Chen S, Wang Y, Li A, Jiang W, Xu Q, Wu M, et al. Etiologies of hospitalized acute bronchiolitis in children 2 years of age and younger: a 3 years’ study during a Pertussis epidemic. Front Pediatr. 2021 Aug 12;9:621381. doi: 10.3389/fped.2021.621381.
     [Google Scholar]
  16. Loeffelholz M, Jianli D. article-title>PCR and its variations. Advanced techniques in diagnostic microbiology. Boston: Springer US; 2012. p. 273–91.
  17. Bellamy EA, Johnston ID, Wilson AG. The chest radiograph in whooping cough. Clin Radiol. 1987Jan; 38:(1):39–43. doi: 10.1016/s0009-9260(87)80397-5.
     [Google Scholar]
  18. Cherry James D, Wendorf K, Bregman B, Lehman D, Nieves D, Bradley JS, et al. An observational study of severe pertussis in 100 infants ≤ 120 days of age. Pediatr Infect Dis J. 2018Mar; 37:(3):202–5. doi: 10.1097/INF.0000000000001710.
     [Google Scholar]
  19. Koenig KL, Farah J, McDonald EC, Thihalolipavan S, Burns MJ. Pertussis: The identify, isolate, inform tool applied to a re-emerging respiratory illness. West J Emerg Med. 2018 Dec 5; 20:(2):191–7. doi: 10.5811/westjem.2018.11.40023.
     [Google Scholar]
  20. Bettiol S, Wang K, Thompson MJ, Roberts NW, Perera R, Heneghan CJ, et al. Symptomatic treatment of the cough in whooping cough. Cochrane Database Syst Rev. 2012 May 16:(5):CD003257. doi: 10.1002/14651858.CD003257.
     [Google Scholar]
  21. Treatment of Pertussis. Centers for Disease Control and Prevention, Centers for Disease Control and Prevention [online]. Available from: www.cdc.gov/pertussis/hcp/clinical-care/index.html [Accessed 18 Aug. 2024].
  22. Altunaiji S, Kukuruzovic R, Curtis N, Massie J. Antibiotics for whooping cough (pertussis). Cochrane Database Syst Rev. 2007 Jul 18; 2007:(3):CD004404. doi: 10.1002/14651858.CD004404.pub3.
     [Google Scholar]
  23. Pertussis [online]. World Health Organization. Available from: www.who.int/teams/immunization-vaccines-andbiologicals/diseases/pertussis [Accessed 18 August 2024].
  24. Law AW, Judy J, Atwell JE, Willis S, Shea KM. Maternal Tdap and influenza vaccination uptake 2017–2021 in the United States: implications for maternal RSV vaccine uptake in the future. Vaccine. 2023 Dec 12; 41:(51):7632–40. doi: 10.1016/j.vaccine.2023.11.009.
     [Google Scholar]
/content/journals/10.5339/qmj.2025.18
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Whooping cough in the most vulnerable: A case series of pertussis in infants younger than three months in Qatar
Qatar Medical Journal 2025, 18 (2025); https://doi.org/10.5339/qmj.2025.18
/content/journals/10.5339/qmj.2025.18
/content/journals/10.5339/qmj.2025.18
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  • Article Type: Research Article
Keyword(s): Infants, maternal vaccination, pediatrics, pertussis, prevention and whooping cough

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