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Qatar Foundation Annual Research Conference Proceedings Volume 2016 Issue 1
- Conference date: 22-23 Mar 2016
- Location: Qatar National Convention Center (QNCC), Doha, Qatar
- Volume number: 2016
- Published: 21 March 2016
361 - 380 of 656 results
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Pristimerin Inhibits Growth and Induces Apoptosis in Human Colorectal Cancer Cells Through the Generation of Reactive Oxygen Species
Background: Colorectal cancer (CRC) is the third most common cancer in Qatar and a major health concern for the Qatari population. Qatar has the highest rate of colon cancer compared to other countries in the eastern Mediterranean, West Asia and North Africa. Colon cancer is the most common cancer among Qatar's male population and according to the world age standard rates, around 20.8% of male Qataris have thi Read More
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A Circulating MicroRNA Signature for the Diagnosis of Clinically Significant Prostate Cancer
Authors: Ali H. Alhasan, Alexander W. Scott, Jia J Wu, Gang Feng, Joshua J. Meeks, C. Shad Thaxton and Chad A MirkinGold nanoparticle cores functionalized with highly oriented shells of oligonucleotides, referred to as spherical nucleic acids (SNAs), are novel three-dimensional oligonucleotide structures with unique properties that are distinct from their linear counterparts. As a result, SNAs exhibit novel biochemical activities that enable them to address many fundamental challenges associated with basic biological processes. They have Read More
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Point Mutation in Chloroquine Resistance-Associated Genes (Pfcrt and Pfmdr-1) in Imported Cases of Malaria in Qatar
Background Imported malaria has been a great challenge for public health in the State of Qatar due to the large number of immigrant workers come from the Indian subcontinent and Sub-Saharan Africa. Antimalarial drug resistance has emerged as one of the greatest challenges facing malaria control today. Chloroquine (CQ) resistance in Plasmodium falciparum (Pf) is associated with genetic polymorphisms in Pf CQR-tr Read More
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Spatiotemporal Visualization of the Regional Myocardial Tissue
Authors: Ali Sheharyar, Lars Linsen, Othmane Bouhali and Teodora ChitiboiAccording to the World Health Organization (WHO), cardiovascular disease is the leading cause of deaths worldwide. The left ventricle (LV), one of the four chambers of the human heart, plays a crucial role in the performance of the entire heart. The abnormal motion of its wall muscle (myocardium) is an important indicator for multiple cardiac pathologies. Nearly, half of all heart failure cases occur due to the decline in Read More
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A Study to Explore how and where the Population of Qatar Source Health Information
Introduction The levels of chronic disease amongst the Qatari population have increased dramatically in recent years. Whilst these diseases are highly prevalent in Qatar, awareness surrounding the recognition of symptoms and the disease itself are limited. Sourcing accurate information about health conditions is crucial. It is currently unknown how Qatari people source information concerning health problems for themsel Read More
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Real Time Investigations of Living Cancer Cells by Using Nuclear Magnetic Resonance (Nmr) Based on Planer Waveguide Nmr Detector
By Ahmad TelfahThe cell metabolism and its link to oncogenic signaling pathways have got significant interest due to their importance in cancer cell analysis, anticancer drugs development, spectroscopic micro imaging of human organs and tissues and many other biomedical applications. But the lack of advanced analytical tools for the investigation of living cell metabolism is still a challenge to be faced. Since NMR spectroscopy is a relia Read More
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Substances Secreted by Starved Human Dermal Fibroblasts Enhancing the Wound Healing Process in Rat without Scar: A Potential Acellular System for Wound Healing
Authors: Pejman Hanifi-Moghaddam and Amrollah MostafazadehBackground Despite being a major cellular component of various engineered skin substituent, underlying mechanism of successful fibroblast transplantation in wound healing is not clear. Here we show that substances derived from starved fibroblast accelerate wound healing process in rat. Material and methods Starved human fibroblast cell culture supernatant (SFS) was prepared and tested for its wound healing capaci Read More
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Simvastatin Inhibits the Function of TRPC1 and Aameliorate Endothelin 1 Induced Cardiac Hypertrophy
Authors: Senthil Selvaraj, Brij B Singh, Jassim Al Suwaidi and Magdi YacoubBackground & Purpose Intracellular Ca2+ plays an important role in the cardiac physiology and development. Augmentation in intracellular Ca2+ activates the hypertrophic response in cardiomyocytes, although the source of the Ca2+ responsible for this is still elusive. We have previously shown that calcium influx through Transient receptor potential canonical 1 (TRPC1) channel is a key mediator of the cardiac hypertrophi Read More
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Noninvasive Diabetes Monitoring with Electronic Nose
Authors: Amine Bermak and Muhammad HassanBackground Diabetes is a chronic illness in which the body cannot manage the levels of sugar, and it affects an estimated 387 million people worldwide. According to World Health Organization it is the 7th leading cause of death in the world. Frequent monitoring (3 to 10 times) of blood glucose is important for diabetes patients to prevent serious health problems, but existing commercial products of blood glucose measu Read More
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Transcriptional Changes of Mycoplasma Contamination in Gene Expression Studies
Authors: Iman Alazwani, Marwan Abumadi, Yasmin Mohamoud and Joel MalekMycoplasma, the smallest self-replicating microorganism, is one of the most significant problems in the cell-culture field. It belongs to the class of Mollicutes, which are characterized by the absence of a cell wall, making them resistant to commonly used antibiotics, such as streptomycin and penicillin. Because of their small size, Mycoplasmas can pass through the 220-nm pores of filters used to sterilize culture media. Owing t Read More
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CMOS Integrated Circuits for DNA Sensing
Authors: Amine Bermak and Saqib MohamadBackground With the advance of semiconductor technologies, bio-technological application-specific integrated circuits (ASICs) have become a major trend of the industry. Examples include Microelectrode measurement array systems for in-vitro and in-vivo physiological research at the cellular level [1] [2]. Using DNA microarrays can lead to a high throughput, which finds wide applications in genome research and drug d Read More
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The Transitional Experience of Post-Diploma Nurses Returning to Study for an Undergraduate Nursing Degree in Qatar
Authors: Christine Macdonald, Carolyn Wolsey, Kathleen Benjamin and Annie ToppingThe Supreme Council of Health in Qatar aims to improve its health care system by strengthening the capabilities of its health care workforce. A university in Qatar supports this national objective by offering a 2 year Bachelor of Nursing program to post-diploma nurses. The attributes gained through baccalaureate level study, particularly clinical reasoning skills and critical analysis are important for nurses to effectively partici Read More
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Epilepsy in Qatar: Causes, Treatment and Outcome
Rationale Epilepsy is one of the most prevalent neurologic conditions. It is estimated to affect 70 million people worldwide. Epilepsy is an important cause of disability and mortality. It is associated with social stigma and significant economic costs. Although epilepsy is a disease with a worldwide distribution, its prevalence varies between different countries. Very little is known about the epidemiology of epilepsy in Qatar. Qatar's p Read More
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Histone Deacetylase Inhibitor Trichostatin A (TSA) and DNA Methyltransferase Inhibitor 5-aza-2′-deoxycitidine (5-AZA) Enhanced the Cisplatin (CDDP) Induced Cytotoxicity of Neuroblastoma Cells, in Vitro
Authors: Dietrich Busselberg, Elizabeth Varghese and Ana-Maria FloreaNeuroblastoma is a childhood cancer that is frequently treated with CDDP. Upon chemotherapeutic treatment, neuroblastoma patients might develop drug resistance. A large body of evidence associates the cytotoxic effect of CDDP in cancer cells with the formation of DNA adducts and thus interference with the DNA replication of cancer cells but also with the increase of the intracellular calcium concentration ([Ca2+]i) t Read More
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Clustering of Medical Images for Analysis: A Fuzzy Approach
Background and Objective Often times, clinicians use a three-dimensional set of medical images to diagnose and plan treatments, which typically include visual identification of structures such as bones and tissues [1]. This can be a challenging task as anatomical structures of interest can contain significant noise, and easily blend with neighboring tissues. We propose to tackle 2 cases: (a) treatment planning of pelvic fractu Read More
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Date-Pathogen Pipeline: A Pipeline to Detect Pathogenic DNA in Date Palm Cultivars
Authors: Gaurav Thareja, Sweety Mathew, Lisa Sara Mathew, Yasmin Ali Mohamoud, Karsten Suhre and Joel A MalekViruses, Bacteria and Fungal pathogens have been responsible for destruction and degradation of plants worldwide. Most often, these pathogens live a symbiotic relationship with the plant, enhancing plant growth and at times as predators, causing a wide variety of diseases. Date palms are cultivated widely in the Middle Eastern region due to their multi-faceted uses and are valued most for their nutritious fruit – the date. Th Read More
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A Web Server for Visualization and Annotation of Genetic Variants Using Genomic Data from Qatar
Authors: Gaurav Thareja, Manish Kumar, Pankaj Kumar and Karsten SuhreIn the last decade, starting from family-based association analysis and progressing to population-based association analysis have helped in understanding etiology of many rare and complex disorders. As of Nov. 2013, National Human Genome Research institute (NHGRI) Catalog of published Genome-Wide Association Studies (GWAS) contained 1,751 manually curated publications with 11,912 SNP-trait associations. Read More
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Carboxybetaine Ester Feature as a Platform for Switchable Surface Properties
Authors: Peter Kasak, Marketa Ilcikova, Tomas Bertok and Jan TkacA lot of strategies for smart approaches on surfaces were applied such as hydrogel layer, polymer brushes or self-assembly monolayers (SAM). [1] Nowadays switchable zwitterionic materials consisting of molecules with internally balanced charge between positive ammonium and negative carboxy group are promising candidates for this application. [2] They can combine antifouling properties of their zwitterion state and co Read More
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A Self-Calibrated Gas Sensing System for Breath Analysis
Authors: Feng Gao, Amine Bermak, Farid Boussaid and Yi-Kuen LeeA self-calibrated gas sensing system for breath analysis is introduced. The system is composed of an array of high sensitivity gas sensor combined with temperature, humidity and flow sensor for calibration. The system is able to diagnose common diseases and help people stop them at early stages. 1. Introduction Breath analysis is a new method for point-of-care health monitoring and diagnosis. Compared to traditional diagn Read More
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Healthcare Workers' Perspective of Organ Donation and Transplant in Qatar – A Qualitative Study
Authors: Tulika Mehta Agarwal, Hassan Al Thani, Yousuf Al Maslamani, Rajvir Singh and Ayman ElmenyarIntroduction Organ donation and transplant is still an evolving field in Qatar. In Qatar, a qualitative study to understand the perspective of the healthcare workers, towards barriers, promoters and system level challenges in organ donation and transplant was lacking. Hence, very limited literature is available on these issues as are experienced by healthcare workers actually involved in the various stages of this process. O Read More
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