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Qatar Foundation Annual Research Forum Volume 2013 Issue 1
- Conference date: 24-25 Nov 2013
- Location: Qatar National Convention Center (QNCC), Doha, Qatar
- Volume number: 2013
- Published: 20 November 2013
141 - 160 of 541 results
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Using whole exome sequencing as a molecular diagnostic tool to identify disease-causing mutations in consanguineous families in Qatar
More LessBackground: Whole exome sequencing (WES), which focuses on sequencing of protein-coding regions of human genome, has greatly improved the identification of causal mutations for diverse human genetic disorders in the past four years. We applied WES as a molecular diagnostic tool to identify disease-causing mutations in consanguineous families displaying autosomal recessive (AR) disorders in Qatar. AR diseases are u Read More
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Quantitative Microbial Risk Assessment For Escherichia Coli O157:H7 In Mutton In Qatar
More LessBackground and Introduction—Foodborne illness has been identified as one of the major hindrances to the advancement of health around the world and bacterial pathogens play a major role in this impediment. Although most of the infections are self-limited, different estimates of the cost of illnesses around the world indicate costly episodes with the numbers ranging from $1,600 to $3,000. The global risk of the foodborne Read More
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The Advice Infrastructure For Generating And Delivering Evidence-Informed Clinical Decision Support Services: A Knowledge Management Approach
By Syed AbidiNext generation computerized healthcare services are destined to be knowledge-centric—i.e. leveraging best-evidence and best clinical practices to provide evidence-informed, patient-centered, safe, timely, and cost-effective care services. In this paper, we present an health informatics based clinical decision support infrastructure—termed as ADVICE (Agile Decisional Validation and Individualized Care Environment)—t Read More
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A Semantic Web Framework To Computerize And Execute Clinical Guidelines: Towards The Handling Of Co-Morbidities In Clinical Decision Support Systems
By Syed AbidiBackground: A Canadian study recommends General Practitioners (GP) to use evidence based Clinical Guidelines (CG) when dealing with co-morbid cardiovascular diseases, in particular for the diagnosis and preliminary management of co-morbid Chronic Heart Failure (CHF) and Atrial Fibrillation (AF). Although paper-based Canadian CG exist for the management of CHF and AF, the challenge for physicians is to simultaneously appl Read More
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Identification Of Genes Involved In The Growth Of Pancreatic Cancer Cells In The Rat Liver Of Nude Rats
By Hassan AdwanPurpose: Owing to aggressiveness and chemo-resistance, pancreatic ductal adeno-carcinoma (PDAC) is characterised by a poor prognosis. At the advanced stage, which is characterised by metastasis into adjacent organs, especially the liver, all systemic treatment approaches have failed, so far. To address this disease spe¬cific dilemma we aimed to establish animal models, which mimic liver metastasis of PDAC and to identif Read More
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Prevention of hospital infections using Ag/ZnO nanoparticle visible light photocatalyst
By Khaled Saoudhospital infection due surface contamination becomes very important field of study in recent years. Such contamination can provide a good environment for different microorganisms (i.e. bacteria, viruses, and fungi) to grow and transmit infectious diseases when they come into contact with human body . Recent studies show that surface contamination is accounted for 100,000 deaths in United States alone. Antibacterial Read More
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A smart wearable technology for fall prevention in patients with diabetes: Application of plantar electrical stimulation
By Bijan NajafiBackground: Neurodegenerative diseases like diabetes can significantly impair patients' postural balance and gait. These negative alterations in balance and gait coupled with peripheral neuropathy (PN) can dramatically reduce patients' ability to perform activities of daily living and also put them on high fall-risk. The purpose of this study is to treat balance deficit due to diabetes and PN using a home wearable technology ba Read More
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Whole genome polymorphism analysis and responsiveness of melanoma to TIL therapy
More LessAdoptive cell transfer therapy (ACT) holds a highly promising treatment for metastatic melanoma patients. ACT involves the ex vivo expansion of autologous antitumor reactive tumor infiltrating lymphocytes and their reinfusion into lymphodepleted patients, accompanied by IL-2 administration. ACT demonstrates objective clinical responsiveness in 40-50% patients, including 10-21% complete responses. However, Read More
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Chairing and leadership in multidisciplinary cancer teams: Development and evaluation of an assessment tool
By Rozh JalilIntroduction: The Multidisciplinary team (MDT) is defined as a "group of people of different healthcare disciplines, which meets together at a given time (whether physically in one place, or by video or teleconferencing) to discuss a given patient and who are each able to contribute independently to the diagnostic and treatment decisions about the patient". These teams meet regularly, review investigation results an Read More
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Role(s) of microRNAs as markers and mediators of insulin resistance
More LessBackground: Early and rapid onset of obesity in the Qatari population, consequent to expansion primarily of abdominal adipose tissue, is closely associated with inflammation and insulin resistance. Recent interest has focused on microRNA (miRNA), both as biomarkers and mediators, of disease and therefore potentially therapeutic targets. MiRNAs are stable, non-coding species involved in the post-transcriptional regulati Read More
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Energy-efficient data reduction techniques for EEG wireless body sensor networks
By Rabab WardWith recent advances in signal processing and very-low-power wireless communications, wireless body sensor networks (WBSNs) are gaining wide popularity. A WBSN consists of multiple miniaturized sensors that are placed on the person's body and are capable of measuring and communicating different physiological signals over time. This study focuses on WBSNs that rely on electroencephalogram (EEG) signals. Read More
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Investigating PARP-1 function in ROS-induced pro-inflammatory senescence of pre-adipocytes
More LessObesity has increased at an alarming rate over the past three decades. It is likely caused by increased caloric intake combined with genetic predisposing factors and is a major risk factor for type 2 diabetes (T2D). Obesity is linked to chronic inflammation, which was proposed as a cause for insulin resistance and T2D. The obese state creates a microenvironment within the adipose tissue that is susceptible to accumulation Read More
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Complexity and some of its applications in health sciences
More LessIn recent years, the field of applied nonlinear dynamics has attracted scientists and engineers across many different disciplines to develop innovative ideas and methods to study complex behavior exhibited by relatively simple tools. In this study, we have investigated some of these tools together with some its applications. Among these applications, here we have chosen one of our resent research work in heart rate com Read More
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Expression and regulation of brown adipose tissue activity by renalase
More LessObesity is an established risk factor for hypertension. About 1 billion adults are overweight globally and numbers appear to be increasing. Stimulating endogenous activation of brown adipose tissue (BAT) mass that has unprecedented metabolic capacity can combat obesity, reverse insulin resistance and reduce comorbidities. Renalase is a recently discovered flavin adenine dinucleotide (FAD)-dependent oxidase, pre Read More
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Towards cell level protein interaction in multivariate bioimages
By Adnan KhanRecently, new bioimaging techniques have been proposed to visualize the interaction of several proteins within individual cells. Such techniques could provide the key to understanding complex biological systems such as the protein interactions involved in cancer. Currently, there is a strong urge for sophisticated analytical methods to extract molecular signatures of diseases (such as cancer) in order to not only understand th Read More
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Mid-range calcium signaling favors activation of Ca2+-activated Cl- channels through functional coupling between SOCE, SERCA and IP3 receptors
More LessCalcium is a ubiquitous signaling molecule involved in various cellular processes, including fertilization, muscle contraction or synaptic transmission. There are two major sources for Ca2+: the extracellular media and intracellular Ca2+ stores, particularly the endoplasmic reticulum (ER). When intracellular stores are depleted, a signal is transmitted from a Ca2+ sensor protein that localizes to the ER membrane (STIM) to the pla Read More
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Engineering Biomolecules To Decorate Nanofibers For Tissue Engineering Heart Valves
More LessBiomimetic nanofibers are essential to produce scaffolds for tissue engineering. The success of this strategy critically depends on the ability of the nanofibers to attract, interact and instruct the appropriate types of cells. This can be achieved through decorating the surface of the nanofibers with customised biomimetic peptides those holding cell-signalling motifs, which could assist nanofibers to engraft characteristics of extra Read More
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Preliminary results and clinical relevance of next generation sequencing in hypertrophic cardiomyopathy patients in Qatar
More LessTitle: Preliminary Results and Clinical Relevance of Next Generation Sequencing in Hypertrophic Cardiomyopathy Patients in Qatar. Kholoud Al-Shafai 1, Despina Sanoudou 1,2, Paul Barton 3 , Lama Shuayb 1 , Emmeleia Nana 2 , Pothitos Pitychoutis 2 , Rachel Buchan 3 , Roddy Walsh 3 , Stuart Cook 3, Magdi Yacoub 1,3, Mohammed Alhashemi 4 1 Qatar Cardiovascular Research Center (QCRC), Qatar Foundation, Doha, Qa Read More
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Differential regulation of brown adipose tissue physiology by orexin A and orexin B
More LessAbstract: Prevalence of obesity and co-morbidities is increasing alarmingly in recent years with over 1 billion adults globally being classified as overweight. Importantly, this also applies to the population in Qatar where about 70% of the total population are expected to be overweight and nearly 20% diabetic by 2015. The profound increase in obesity has a severe socio-economic burden for public health systems worldwide Read More
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Wearable And Wireless Activities Aware Body-Centric Ecg Network (Wiser-Ecg)
More LessThe interest in smart bodyâ€centric wireless networks (BCWNs) for healthcare applications is increasing as clinical acceptance of wireless technology is growing; they potentially combine ease of use with greater independence to the patient. BCWNs are emerging for inâ€patient and outâ€patient monitoring of ECGs, pulse oximeter, blood pressure, insulin pumps and blood glucose. Coupled with the use of location†Read More
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