1887
  1. الرئيسية
  2. A-Z Publications
  3. Journal of Emergency Medicine, Trauma and Acute Care
  4. المجلد 2022, العدد 4
  5. المقالة
Volume 2022, Issue 4
  • ISSN: 1999-7086
  • E-ISSN: 1999-7094

ملخص

Many drugs can cause methemoglobinemia, and dapsone is one of the most familiar. Dapsone is used to treat skin disorders like leprosy, and infections like Pneumocystis jiroveci pneumonia. It is also used off-label in conditions like dermatitis herpetiformis, and relapsing polychondritis. In this case report, a 26-year-old male presented to the emergency department with fever and generalized weakness complaints. He was on treatment for lepromatous leprosy with dapsone, clofazimine, and rifampicin. His room air oxygen saturation was 80 %, so he was started on high-flow oxygen therapy and vitamin C. His blood gas and methemoglobin levels were frequently monitored till the methemoglobin level was normal. By the third day, he maintained his saturation above 95% on room air The results in this work emphasize the importance of evaluating hypoxia for uncommon causes like methemoglobinemia as misdiagnosis can lead to fatal complications.

© 2022 Peediyakkal, Khatib, Elshafei, Ananthegowda, Zeer, Shaik, Baiou, Kannappilly, Allafi, Venkatesan, Nashwan, licensee HBKU Press.
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References

  1. Prasad R, Verma SK, Singh R, Hosmane G. Concomittant pulmonary tuberculosis and borderline leprosy with type-II lepra reaction in single patient. Lung India: Official Organ of Indian Chest Society. 2010; 27:(1):19.
     [Google الباحث العلمي]
  2. Wolf R, Matz H, Orion E, Tuzun B, Tuzun Y. Dapsone. Dermatology online journal. 2002; 8:(1):.
     [Google الباحث العلمي]
  3. Provost TT. Lupus band test. International journal of dermatology. 1981; 20:(7):475–81.
     [Google الباحث العلمي]
  4. Guragain S, Upadhayay N, Bhattarai BM. Adverse reactions in leprosy patients who underwent dapsone multidrug therapy: a retrospective study. Clinical pharmacology: advances and applications. 2017;:9:73.
     [Google الباحث العلمي]
  5. Bhat RM, Radhakrishnan K. A case report of fatal dapsone-induced agranulocytosis in an Indian midborderline leprosy patient. Leprosy review. 2003; 74:(2):167–70.
     [Google الباحث العلمي]
  6. Srour M, Go A, Osmon S. A case of dapsone-induced methemoglobinemia. Chest. 2019; 156:(4):A2115.
     [Google الباحث العلمي]
  7. Deps PD, Nasser S, Guerra P, Simon M, Birshner RDC, Rodrigues LC. Adverse effects from multi-drug therapy in leprosy: a Brazilian study. Leprosy review. 2007; 78:(3):216–22.
     [Google الباحث العلمي]
  8. Esbenshade AJ, Ho RH, Shintani A, Zhao Z, Smith LA, Friedman DL. Dapsone-induced methemoglobinemia: A dose-related occurrence? Cancer. 2011; 117:(15):3485–92.
     [Google الباحث العلمي]
  9. Swartzentruber GS, Yanta JH, Pizon AF. Methemoglobinemia as a complication of topical dapsone. N Engl J Med. 2015; 372:(5):491–2.
     [Google الباحث العلمي]
  10. Kane GC, Hoehn SM, Behrenbeck TR, Mulvagh SL. Benzocaine-induced methemoglobinemia based on the Mayo Clinic experience from 28 478 transesophageal echocardiograms: incidence, outcomes, and predisposing factors. Archives of internal medicine. 2007; 167:(18):1977–82.
     [Google الباحث العلمي]
  11. Ash-Bernal R, Wise R, Wright SM. Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. Medicine. 2004; 83:(5):265–73.
     [Google الباحث العلمي]
  12. Mack E. Co-oximetry. Pediatrics in review. 2007; 28:(2):73–4.
     [Google الباحث العلمي]
  13. Haymond S, Cariappa R, Eby CS, Scott MG. Laboratory assessment of oxygenation in methemoglobinemia. Clinical Chemistry. 2005; 51:(2):434–44.
     [Google الباحث العلمي]
  14. Barker SJ, Tremper KK, Hyatt J. Effects of methemoglobinemia on pulse oximetry and mixed venous oximetry. Anesthesiology. 1989; 70:(1):112–7.
     [Google الباحث العلمي]
  15. Kelner M, Bailey D. Mismeasurement of methemoglobin (“methemoglobin revisited”). Clinical chemistry. 1985; 31:(1):168–9.
     [Google الباحث العلمي]
  16. Woodhouse K, Henderson D, Charlton B, Peaston R, Rawlins M. Acute dapsone poisoning: clinical features and pharmacokinetic studies. Human toxicology. 1983; 2:(3):507–10.
     [Google الباحث العلمي]
  17. Cortazzo JA, Lichtman AD. Methemoglobinemia: a review and recommendations for management. Journal of cardiothoracic and vascular anesthesia. 2014; 28:(4):1043–7.
     [Google الباحث العلمي]
  18. Coleman MD, Coleman NA. Drug-induced methaemoglobinaemia. Drug safety. 1996; 14:(6):394–405.
     [Google الباحث العلمي]
  19. Naymagon L, Berwick S, Kessler A, Lancman G, Gidwani U, Troy K. The emergence of methemoglobinemia amidst the COVID-19 pandemic. American journal of hematology. 2020.
     [Google الباحث العلمي]
  20. Faley B, Chase H. A case of severe amyl nitrite induced methemoglobinemia managed with methylene blue. J clinic toxicol. 2012; 2:(4):127–8.
     [Google الباحث العلمي]
  21. Tejesh C, Shivanna S, Manjunath A, Prathima P. ICU management of methemoglobinemia due to unknown compound poisoning. Journal of anaesthesiology, clinical pharmacology. 2013; 29:(1):139.
     [Google الباحث العلمي]
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Methemoglobinemia induced by Dapsone: A case report
Journal of Emergency Medicine, Trauma and Acute Care 2022, 22 (٢٠٢٢); https://doi.org/10.5339/jemtac.2022.22
/content/journals/10.5339/jemtac.2022.22
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الموضوعات الرئيسية Dapsone, Drug-Induced Methemoglobinemia, hypoxia and Methemoglobinemia

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