1887
Volume 2005, Issue 1
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

ملخص

To study the antimicrobial resistance pattern of aerobic Gram-negative bacilli isolated from patients in intensive care units in Hamad Medical Corporation, 108 non-duplicate isolates from 60 patients with nosocomial infections were determined by Vitek machine. The minimal inhibitory concentration of 14 antimicrobials was determined by E-test and results were interpreted according to the National Committee for Clinical Laboratory Standards guidelines. The most common species was Pseudomonas aeruginosa High levels of resistance were seen to second and third generation cephalosporins, piperacillin, fi-lactam Ji-lactamase inhibitors combinations, and gentamicin. The most active agents were amikacin, meropenem and imipenem (resistance 19%, 19%, 20% respectively). We conclude that second and third generation cephalosporins, piperacillin, fi-lactam/fi-lactamase inhibitors combinations and gentamicin are not suitable drugs for empirical monotherapy for aerobic Gram-negative infections in intensive care units in Qatar.

Loading

جارٍ تحميل قياسات المقالة...

/content/journals/10.5339/qmj.2005.1.13
٢٠٠٥-٠٦-٠١
٢٠٢٥-٠١-٠٣
Loading full text...

Full text loading...

References

  1. Rahal JJ. Extended-spectrum fi-lactamases: How big is the problem. CMI. 2000; 6:suppl. 2:26.
    [Google الباحث العلمي]
  2. McGown JE. Antimicrobial resistance in hospital organisms and its relation to antimicrobial agent use. Rev Infect Dis. 1983; 5::10331048.
    [Google الباحث العلمي]
  3. Flaherty JP, Weinstein RA. Nosocomial infection caused by antibiotic-resistant organisms in the intensive care units. Infect Control Hosp Epidemiol. 1966; 17::236248.
    [Google الباحث العلمي]
  4. Hanberger H, Diekema D, Fluit A, Jones R, Struelens M, Spencer R, Wolff M. Surveillence of antibiotic resistance in European ICUS. J Hosp Infect;. 2001; 48::161176.
    [Google الباحث العلمي]
  5. Hunter PA, Reeves DS. The current status of surveillance of resistance to antimicrobial agents. J Antimicrob Chemother. 2002; 49::1723.
    [Google الباحث العلمي]
  6. Huovinen P, cars O. Control of antimicrobial resistance: Time for action. BMI. 1998; 317::613614.
    [Google الباحث العلمي]
  7. Chow J, Fine M, Shales DM, et al., Enterobacter bacteremia: Clinical features and emergence of antibiotic resistance during therapy. Ann Intern Med. 1991; 115::585590.
    [Google الباحث العلمي]
  8. Rello R, Ausina V, Ricat M, Castella I, Parts G. Impact of previous antimicrobial therapy on the etiology and outcome of ventilator associated pneumonia. Chest. 1993; 104::12301235.
    [Google الباحث العلمي]
  9. Carmeli Y, Troillet N, Eliopoulos GM, Samore MH. Emergence of antibiotic-resistant Pseudomonas aeruginosa: Comparison of risks associated with different antipseudomonal agents. Antimicrobial Agents Chemother. 1999; 43::13791382.
    [Google الباحث العلمي]
  10. Pechere JC, Kohler T. Patterns and modes of beta-lactama resistance in Pseudomonas aerugenisoa. Clin Microbiol Infect. 1999; 5::S15S18.
    [Google الباحث العلمي]
  11. Hanberger H, Garcia-Rodriguez JA, Gobernado M, Goossens H, Nilsson LE, Struelens MJ. Antibiotic susceptibility among aerobic Gram-negative bacilli in intensive care units. JAMA. 1999; 281::6771.
    [Google الباحث العلمي]
  12. Archibald L, Phillips L, Monnet D, McGowan JE, Tenover F, Gaynes R. Antimicrobial resistance in isolates from inpatients and outpatients in the United States: increasing importance of the intensive care unit. Clin Infect Dis. 1997; 24::211215.
    [Google الباحث العلمي]
  13. Spencer RC. The emergence of epidemic, multiple-antibioticresistant Stenotrophomonas (Xanthomonas) maltophilia and Burkholderia (Pseudomonas) cepacia. J Hosp Infect. 1995; 30: Suppl:S453S464.
    [Google الباحث العلمي]
  14. Villarino Me, Steveus LE, Schable B, et al., Risk factors for epidemic Xanthomonas maltophilia: a case-control study of predisposing factors. Infect Control Hosp Epidemiol. 1990; 11::134138.
    [Google الباحث العلمي]
  15. Livermore DM. Beta-lactamases in laboratory and clinical resistance. Clin Microbiol Rev. 1995; 8::557584.
    [Google الباحث العلمي]
  16. Lortholary O, Fagon JY, Hoi AB, et al., Nosocomial acquisition of multiresistant Acinetobacter baumannii: risk factors and prognosis. Clin Infect Dis. 1995; 20::790796.
    [Google الباحث العلمي]
  17. Jawad A, Seifert H, Snelling AM, Heritage J, Hawkey PM. Survival of Acinetobacter baumannii on dry surfaces: comparison of outbreak and sporadic isolates. J Clin Microbiol. 1998; 7::19381941.
    [Google الباحث العلمي]
  18. Dy ME, Nord JA, La Bombardi VJ, Kislak JW. The emergence of resistant strains of Acinetobacter baumannii: clinical and infection control implications. Infection control Hosp Epidemiol. 1999; 20::565567.
    [Google الباحث العلمي]
  19. Radberg G, Nels son L, Swensson S. Development of quinoloneimipnem cross resistance in Pseudomonas aeruginosa during exposure to ciprofloxacin. Antimicrobial Agent Chemother. 1990; 34::21422147.
    [Google الباحث العلمي]
  20. Fung-Tome J, Kolek B, Bonner D. Ciprofloxacin-induced low level resistance to structurally unrelated antibiotics in Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Antimicrob Agent Chemother. 1993; 37::12891298.
    [Google الباحث العلمي]
/content/journals/10.5339/qmj.2005.1.13
Loading
  • نوع المستند: Research Article
الموضوعات الرئيسية bacterial resistancegram negative bacteria and Intensive care units

الأكثر اقتباسًا لهذا الشهر Most Cited RSS feed

هذه الخانة مطلوبة
يُرجى إدخال عنوان بريد إلكتروني صالح
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error