1887
Volume 2006, Issue 2
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

ملخص

To define the demographic, clinical and laboratory features, and outcome of patients with Kikuchi-Fujimoto disease in Qatar and to compare it with those reported by others, fourteen cases of Kikuchi-Fujimoto disease seen at Hamad Medical Corporation between 1995 and 2004 were reviewed retrospectively. Unusually there was an unexplained male predominance amongst the ten males and four females even amongst the Qatari nationals who comprised 57% of the cases. All had lymphadenopathy, mostly cervical, and less commonly fever; anorexia, chills, weight loss, hepatomegaly, and skin rash. The diagnosis was made by lymph node biopsy, with no indication of any etiologic agent All patients survived although symptomatic treatment with non-steroidal anti-inflammatory drugs and steroids was required in five patients. There was recurrence in two patients. It seems that Kikuchi-Fujimoto disease is rare in Qatar although the incidence might be increasing possibly due to greater awareness amongst clinicians. The clinical features are similar to those reported by others but certain diagnosis requires lymph node biopsy. The outcome is good.

Loading

جارٍ تحميل قياسات المقالة...

/content/journals/10.5339/qmj.2006.2.13
٢٠٠٦-١١-٠١
٢٠٢٤-٠٧-١٩
Loading full text...

Full text loading...

References

  1. Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytes: A clinicopathologic study. Nippon Ketsueki Gakkhi Zazzhi. 1972; 35::378380.
    [Google الباحث العلمي]
  2. Fujimoto Y, Korjiria Y, Yamaguchi K. Cervical subacute necrotizing lymphadenitis: a new clinicopathological entity. Naika. 1972; 20::920927.
    [Google الباحث العلمي]
  3. Turnner RR, Martin J, Dorfman RF. Necrotizing lymphadenitis: A study of 30 cases. Am J Surg Pathol. 1983; 7::115123.
    [Google الباحث العلمي]
  4. Dorfman RF, Berry GJ. Kikuchi's histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Semin Diagn Pathol. 1988; 5::329345.
    [Google الباحث العلمي]
  5. Pileri S, Kikuchi M, Helbron D, Lennort K. Histiocytic necrotizing lymphadenitis without granulocytic infiltration. Virchows Arch Abrol Anab. 1982; 395::257271.
    [Google الباحث العلمي]
  6. Abba AA, Afzal M, Al-Moharab FI, Baez-Gianreco A. Kikuchi disease: A clinicopathologic analysis of 13 cases from Riyadh Central Hospital. Annals of Saudi Medicine. 1995; 15::288290.
    [Google الباحث العلمي]
  7. Ejeckam GC, Azadeh B, Matar 1, Aboud O. Kikuchi's lymphadenitis in Qatar. East African Medical Journal. 1993; 70::575577.
    [Google الباحث العلمي]
  8. Unger P, Rappaport K, Strauchen J, et al., Necrotizing lymphadenitis (Kikuchi's disease). Arch Pathol Lab Med. 1987; 111::1031.
    [Google الباحث العلمي]
  9. Kutty MK, Anim JT, Sowayen S. Histiocytic necrotizing lymphadenitis in Saudi Arabia. Trop Geogr Med. 1991; 43::68.
    [Google الباحث العلمي]
  10. Kuo T, Shi Y. Surgical pathology of lymph node biopsy specimens in Taiwan with an update on adult Tcell leukaemia/ lymphoma. In: Hanoaka MKadin MEMikata A, eds. Lymphoid malignancy: immunocytology and cytogenetics. New York: Field and Wood 1990;:109115.
    [Google الباحث العلمي]
  11. Asano S, Akaike Y, Jinnouchi H, et al., Necrotizing lymphadenitis: a review of clinicopathological, immunohistochemical and ultrastructural studies. Hematol Oncol. 1990; 8::251.
    [Google الباحث العلمي]
  12. Kuo TT. KikuchVs disease. A clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology, and DNA ploidy. Am J Surg Pathol. 1995; 19::798809.
    [Google الباحث العلمي]
  13. Yen A, Fearneyhough P, Raimer SS, Hudnall SD. EBVassociated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestation. J Am Acad Dermatol. 1997; 36::342.
    [Google الباحث العلمي]
  14. Huh J, Kang GH, Gong G, et al., Kaposi's sarcomaassociated herpesvirus in Kikuchi's disease. Hum Pathol. 1998; 29::1091.
    [Google الباحث العلمي]
  15. Yufu Y, Matsumoto M, Miyamura T, et al., Parvovirus B19-associated haemophagocytic syndrome with lymphadenopthy resembling histiocytic necrotizing lymphadenitis (KikuchVs disease). Br J Hematol. 1997; 96::868.
    [Google الباحث العلمي]
  16. Niedobitek G, Herbst H, Young LS, Brooks L, Masucci MG, Crocker J, et al., Patterns of Epstein-Barr Virus infection in non-neoplastic lymphoid tissue. Blood. 1992; 79::25202526.
    [Google الباحث العلمي]
  17. Anagnostopoulos I, Hummel M, Korbjuhn P, Papadaki T, Anagnostou D, Stein H. Epstein-Barr virus in Kikuchi-Fujimoto disease. Lancet. 1993; 341::893.
    [Google الباحث العلمي]
  18. Sumiyoshi Y, Kikuchi M, Ohshima K, Yoneda S, Kobari S, Takeshita M, et al., Human herpes virus 6 genome in histiocytic necrotizing lymphadenitis (KikuchVs disease) and other forms of lymphadenitis. Am J Clin Pathol. 1993; 99::609614.
    [Google الباحث العلمي]
  19. Kuo T. Cutaneous manifestation of KikuchVs histiocytic necrotizing lymphadenitis. Am J Surg Pathol. 1990; 420::872.
    [Google الباحث العلمي]
  20. Sato Y, Kuno H, Oizumi K. Histiocytic necrotizing lymphadenitis (KikuchVs disease) with aseptic meningitis. J Neurol Sci. 1999; 163::187.
    [Google الباحث العلمي]
  21. Mathew LG, Cherian T, Srivastava VM, Raghupathy P. Histiocytic necrotizing lymphadenitis (Kikuchi's disease) with aseptic meningitis. Indian Pediatr. 1998; 35::775.
    [Google الباحث العلمي]
  22. Litwin MD, Kirkham B, Henderson DR, Milazzo SC. Histiocytic necrotizing lymphadenitis in systemic lupus erythematosis. Ann Rheum Dis. 1992; 51::805807.
    [Google الباحث العلمي]
  23. Hansmann ML, Kikuchi M, Wacker HH, et al., Immunohistochemical monitoring of plasmcytoid cells in lymph node sections of Kikuchi-fujimoto disease by a new pan-macrophage antibody Ki-MIP. Hum Pathol. 1992; 23::676680.
    [Google الباحث العلمي]
  24. Hsueh EJ, Ko WS, Hwang WS, Yam LT. Fine needle aspiration of histiocytic necrotizing lympadenitis (Kikuchi's disease). Diagn Cytopathol. 1993; 9::448452.
    [Google الباحث العلمي]
  25. Tong TR, Chan OW, Lee KC. Diagnosing Kikuchi disease on fine needle aspiration biopsy: a retrospective study of 44 cases diagnosed by cytology and 8 by histopathology. Acta Cytol. 2001; 45::953957.
    [Google الباحث العلمي]
  26. Tsang WY, Chan JK. Fine-needle aspiration cytologic diagnosis of KikuchVs lymphadenitis. A report of 27 cases. Am J Clin Pathol. 1994; 102::454458.
    [Google الباحث العلمي]
  27. Jang YJ, Park KH, Seok HJ. Management of Kikuchi's disease using glucocorticoid. J Laryngol Otol. 2000; 114::709.
    [Google الباحث العلمي]
  28. Chan JKC, Wong KC, Ng CS. A fatal case of multicentric Kikuchi's histiocytic necrotizing lymphadenitis. Cancer. 1989; 63::18561862.
    [Google الباحث العلمي]
  29. Neill D, Grady J, Variend S. Child fatality associated with pathological features of histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease). Pediatr Pathol Lab Med. 1998; 18::7988.
    [Google الباحث العلمي]
/content/journals/10.5339/qmj.2006.2.13
Loading
  • نوع المستند: Research Article
الموضوعات الرئيسية fever of unknown originKikuchi-Fujimoto disease and lymphadenopathy

الأكثر اقتباسًا لهذا الشهر Most Cited RSS feed

هذه الخانة مطلوبة
يُرجى إدخال عنوان بريد إلكتروني صالح
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error