1887
Volume 2007, Issue 2
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

ملخص

Objectives: The objective of the study was to determine prevalent pneumococcal serotypes causing infections in different age groups, their susceptibility to fi-lactams and macrolides and whether these serotypes are covered by the conjugated pneumococcal vaccines.

Methods: Streptococcus pneumonia strains isolated from different patients at Hamad Medical Corporation, Microbiology Laboratory between September 1999 and July 2000 were sent to Statum Serum Institute in Denmark for serotyping. The strains were tested for their susceptibility to penicillin, ceftriaxone and erythromycin by Vitek 2 machine (bioMerieux, France) at Hamad Medical Corporation, Microbiology Laboratory.

Results: Predominant serotypes in children <  2 years were: 6A, 6B, 9V, 11 A, 14,19A, 19F and 23 F, predominant serotypes in children between 2-7years were: 3, 6B, 15B, 19A, 19F and 23F, while predominant serotypes in adults were: 3, 8, 9V, 14,15B, 20 and 22F. In children less than 2 years, the 7-valent and 9-valent conjugate vaccines covered 52% of serotypes. 33% of strains were moderately resistant to penicillin, 27% showed high-level resistance to penicillin, 30% resistant to erythromycin and 2% resistant to ceftrixone.

Conclusion: The 7-valent and 9-valent vaccines offer similar coverage of serotypes in children less than 2 years while the 11-valent vaccines offers 55% coverage. This difference is not statistically significant. Resistance to penicillin was high which leaves ceftriaxone as the drug of choice for empirical treatment of invasive pneumococcal diseases.

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References

  1. Henrichsen J. Six newly recognized types of Streptococcus pneumonia. J. Clin Microbio. 1995; 33::27592760.
    [Google الباحث العلمي]
  2. Gray BM, Dillon HCJR, Epidemiologic studies of Streptococcus pneumonia in infants antibody to type 3, 16, 14 and 23 in the first two years of Infect Dis. 1988; 158::948953.
    [Google الباحث العلمي]
  3. Dagan R, Fraser D. Cojugate pneumococcal vaccine and antibiotic-resistant Stretococcus pneumoniae:herd immunity and reduction of otitis morbidity. Pediatric Infections Disease Journal. 2000; 19:5:S79S87.
    [Google الباحث العلمي]
  4. Zielen S, Buhring I, Strand N, Reichenbach J, Hofmann D. Immunogenicity and tolerance of a 7-Valent Pneumococcal Conjugate vaccine in Nonresponders to the 23-Valent Pneumococcal Vaccine. Infection and Immunity. 2000; 68:3:14351440.
    [Google الباحث العلمي]
  5. Wenger JD, Hightower AW, Facklam RR, Gaventa S, Broome CV. Bacterial meningitis in the United States, 1986, Report of a multistate surveillance study. J. Infect Dis. 1990; 162::13161323.
    [Google الباحث العلمي]
  6. Klugman KP. Pneumococcal resistance to antibiotics. Clin Microbio Rev. 1990; 3::171196.
    [Google الباحث العلمي]
  7. Gherardi GC, Whitney R, Racklam , Beal . Major related sets of antibiotic resistant penumonococci in the United States as determined by pulsed-field gel electrophoresis and pbplapbp2b-pbp2x-dhf restriction profiles. J. Infect Dis. 2000; 181::216219.
    [Google الباحث العلمي]
  8. Stephanie J Schrag, Bernard B, Dowell Scott F. Limiting the spread of resistant pneumococci biological and epidemiological evidence for the effectiveness of alternative interventions. Clin Microbio Rev. 2000; 13::588601.
    [Google الباحث العلمي]
  9. Moroney, J A. Farley, L. Harrison, J. Patterson, M. Cetron and A. Schuchat 1997. Therapy and outcome of meningitis caused by drug-resistant Streptococcus pneumoniae in three US cities 1994-1996, abst. 48. In abstract of the 35th annual meeting of the Infectious Diseases Society of America.
  10. Sheldon L, Kaplan , Edward O, Mason JR. Management of Infections due to antibiotic resistant Streptococcus pneumonia. Clin Microbiol Rev. 1998; 11:4:628644.
    [Google الباحث العلمي]
  11. Obaro SK. The new pneumococcal vaccines. Clin Microbiol Infect. 2002; 8:10:623644.
    [Google الباحث العلمي]
  12. Fridman E, Gill IC, Heal G, Central nervous system complication associated with acute otitis media in childrenlaryngoscope. 1990; 100::149151.
    [Google الباحث العلمي]
  13. Konppari G, et al., Pneumococcal acute otitis media in children. Clin Microbiol Infect. 2000; 6::6973.
    [Google الباحث العلمي]
  14. Beiman RF, et al., Emerging of drug resistant pneumonococcal infection in the United States. J. Am Med Assoc. 1994; 271::18311835.
    [Google الباحث العلمي]
  15. Verhaegen J, Glupczynski Y, Verbist L, et al., Capsular types and antibiotic susceptibility of pneumococcus isolated from patients in Belgium with serious infections 1980–1993. Clin Infect Dis. 1995; 20::13391345.
    [Google الباحث العلمي]
  16. Fenoll A, Martin Bourgon C, Munoz R, Vicioso D, Casaql J. Serotypes distribution and antimicrobial resistance of S.pneumonia isolated causing systemic infections in Spain, 1979–1989. Rev Infec Dis. 1991; 13::5660.
    [Google الباحث العلمي]
  17. Insel RA, Anderson PW. Oligo saccharide protein conjugate vaccines induce and prime for oligoclonal log, G antibody responses to the Haemophilus influenzae b capsular polysaccharide in human infants. J. Exp Med. 1986; 163::262269.
    [Google الباحث العلمي]
  18. Steubgijf MGK, Edwards H, Keyserling ML, Thomas C, Jhonson D, Madore M, Hogerman DH. Arandomized comparison of three bivalent Streptococcus pneumonia glycoprotein conjugate vaccines in young children, effect of polysaccharide size and linkage characteristics. Pediatric Infect Dis J. 1994; 13::368372.
    [Google الباحث العلمي]
  19. Hansdroff WP, Bryant J, Paradiso PR, Siber GR. Which pneumococcal serogroups cause the most invasive disease implications for conjugate vaccine formulation and use, Part 1. Clin Infect Dis. 2000; 30::100121.
    [Google الباحث العلمي]
  20. David E, Brile , et al., Pneumococcal diversity consideration for new vaccine strategies with emphasis on pneumococcal surface protein. A. Clin Microbiol Rev. 1998; 11:4:645657.
    [Google الباحث العلمي]
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  • نوع المستند: Research Article
الموضوعات الرئيسية antibiotic Resistanceconjugate vaccine and S.pneumoniae

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