1887
  1. الرئيسية
  2. A-Z Publications
  3. Qatar Medical Journal
  4. المجلد 2008, العدد 2
  5. المقالة
Volume 2008, Issue 2
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

ملخص

A prospective! descriptive! non-comparative pilot study was used to evaluate the efficacy of intravitreal injection of triamcinolone acetonide (TA) for the treatment of patients with refractory diabetic macular edema that had not responded to laser treatment. Forty eyes of 35 patients with visual acuity (VA) < 6/12 were infected with TA 4 mgl 0.1 cc under topical anesthesia. Results were assessed and analyzed using changes in visual acuity (VA), retinal thickness (RT) and macular volume measured by optical coherence tomography (OCT). In 62.85 % of cases the VA improved by more than two Snellen's lines, the initial VA (mean! log MAR) being 0.67 changing to 0.31 after six months (p = 0.008). RT improved in all patients, having the most remarkable improvement in the Macular Volume, with a decrease of 2.7 mm3 at the end of the study (p = 0.009). Both improvement ofVA and RT were more marked during the early follow-up. The most common complication was ocular hypertension (OHT) in 22.5 % of eyes, all of which responded to medical antiglaucoma treatment. Intravitreal injection ofTA looks to be a useful option for the treatment of refractory diabetic macular edema.

© 2008 El Shafei, Martinez, Al Hashimi, Allaftah, Farouq, licensee Bloomsbury Qatar Foundation Journals.
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References

  1. Klein R, Klein E, Moss SE. The Wisconsin Epidemiologic Study of Diabetic Retinopathy, IV: diabetic macular edema. Ophthalmology. 1984; 91::1464–1474.
     [Google الباحث العلمي]
  2. Early Treatment Diabetic Retinopathy Study Research Group. Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Arch Ophthalmol. 1985; 103::1796–1806.
     [Google الباحث العلمي]
  3. Lee CM, Oik RJ. Modified grid laser photocoagulation for diffuse diabetic macular edema. Long term visual results. Ophthalmology. 1991; 98::1594–1602.
     [Google الباحث العلمي]
  4. Antcliff RJ, Spalton DJ, Stanford MR. Intravitreal Triamcinolone Acetonide for uveitic cystoid macular edema: An optical coherence tomography study. Ophthalmology. 2001; 108::765–772.
     [Google الباحث العلمي]
  5. Nauck M, Roth M, Tamm M. Induction of vascular endothelial growth factor by platelet-activating factor and platelet-derived growth factor is downregulated by corticosteroids. Am J Respir Cell Mol Biol. 1997; 16::398–406.
     [Google الباحث العلمي]
  6. Antonetti DA, Barber AJ, Hollinget LA. Vascular endothelial growth factor induces rapid phosphorylation of tight junctions proteins occludin and zonula occluden 1. J Biol Chem. 1999; 274::23463–23467.
     [Google الباحث العلمي]
  7. Bresnich GH. Diabetic maculopathy: A critical review highlighting diffuse macular edema. Ophthalmol. 1983; 90::1301–1307.
     [Google الباحث العلمي]
  8. Bresnick GH. Diabetic macular edema: A review. Ophthalmol. 1986; 93::989–997.
     [Google الباحث العلمي]
  9. Gillies MC, Su T, Stayt J. Effect of high glucose on permeability of retinal capillary endothelium. Invest Ophthalmol Vis Sci. 1997; 38::635–641.
     [Google الباحث العلمي]
  10. Gardner TW, Lieth E, Khin SA. Astrocytes increases barrier properties and ZO-1 expression in retinal vascular endothelial cells. Invest Ophthalmol Vis Sci. 1997; 38::2423–2427.
     [Google الباحث العلمي]
  11. Wallow IHL, Engerman RL. Permeability and patency of retinal blood vessels in experimental diabetes. Invest Ophthalmol Vis Sci. 1977; 16::447–460.
     [Google الباحث العلمي]
  12. Vinores SA, Niel EV, Swerdorff JL. Electron microscopic immunocytochemical evidence for the mechanism of blood-retinal barrier breakdown in galactosemic rats. Exp Eye Res. 1993; 57::723–735.
     [Google الباحث العلمي]
  13. Ashton N. Studies of the retinal capillaries in relation to diabetic and other retinopathies. Br J Ophthlamol. 1963; 47::521–538.
     [Google الباحث العلمي]
  14. Cogan DG, Toussaint D, Kubawara T. Retinal vascular patterns. Arch Ophthalmol. 1961; 66::100–112.
     [Google الباحث العلمي]
  15. Krupin T, Waltman SR, Szewczyck P. Fluorometric studies on the blood-retinal barrier in experimental animals. Arch Ophthalmol. 1982; 100::631–634.
     [Google الباحث العلمي]
  16. Wilson CA, Berkowitz BA, Sato Y. Treatment with intravitreal steroids reduces blood-retinal barrier breakdown due to retinal photocoagulation. Arch Ophthalmol. 1992; 110::1155–1159.
     [Google الباحث العلمي]
  17. Jonas JB, Sofker A. Intraocular injection of crystalline cortisone as adjunctive treatment of diabetic macular edema. Am J Ophthlamol. 2001; 132::425–427.
     [Google الباحث العلمي]
  18. Martidis A, Duekr JS, Greenberg PB. Intravitreal Triamcinolone for refractory diabetic macular edema. Ophthlamology. 2002; 109::920–927.
     [Google الباحث العلمي]
  19. Jonas JB, Kreissig I, Sofker A. Intravitreal injection of triamcinolone for diffuse diabetic macular edema. Arch Ophthlamol. 2003; 121::57–61.
     [Google الباحث العلمي]
  20. Chieh JJ, Roth DB, Liu M. Intravitreal triamcinolone acetonide for diabetic macular edema. Retina. 2005; 25::828–834.
     [Google الباحث العلمي]
  21. Jonas JB, Kreissig I, Degenring R. Intraocular pressure after intravitreal injection of triamcinolone acetonide. Br J Ophthalmol. 2003; 87::24–27.
     [Google الباحث العلمي]
  22. Roth DB, Chieh JJ, Spirn MJ. Non-infectiuos endohthalmitis associated with intravitreal triamcinolone injection. Arch Ophthlamol. 2003; 121::1279–1282.
     [Google الباحث العلمي]
  23. Jonas JB, Hayer JR, Panda-Jonas S. Intravitreal injection of crystalline cortisone as adjunctive treatment of proliferative vitreo-retinopathy. Br J of Ophthalmol. 2000; 84::1064–1067.
     [Google الباحث العلمي]
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  • نوع المستند: Research Article

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