1887
Volume 2010, Issue 1
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

ملخص

To describe the characteristics of Pseudomonas aeruginosa (P. aeruginosa) in cystic fibrosis (CF) patients with CFTR 11234V in a large kindred family in Qatar, medical and laboratory records were reviewed of 46 patients of CF with CFTR 11234V from 25 families arising from a single large Arab kindred tribe who attended the CF clinic between May 2002 and June 2008. Thirty eight CF patients, who were negative for P. aeruginosa at first lower respiratory culture, were enrolled in the study. The diagnosis of CF was confirmed by sweat test and molecular genetic study. Trypticase soy agar with 5% sheep blood, McConkey agar, oxidative-fermentative polymyxin B-bacitracin lactose agar, Hemophilus isolation agar and mannitol salt agar were used as selective media for the isolation of important CF respiratory pathogens. The prevalence of (P. aeruginosa) in lower respiratory cultures from 46 patients was 60.9%. Twenty (52.6%) of 38 CF patients with CFTR 11 234V acquired P\ aeruginosa with no seasonal variation. Positive siblings with P. aeruginosa were found in 70% indicating cross-infection within the family. The median (range) age at first detection of P. aeruginosa was 12.5 (1–19) years. There was no significant difference between males and females in acquisition of P. aeruginosa. P\ aeruginosa of mucoid phenotype was detected in 11 (55%) of 20 with additional organisms, 5. aureusbe'mg the second isolated organism in nine (81.8%) of the 11. Conclusion: A larger prospective study in a cohort of CF patients with CFTR 11234V in the Arabian Gulf region is required to determine the risk factors for acquisition of P. aeruginosa with early aggressive antipseudomonal therapy.

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References

  1. Burns Ji, Gibson RL, McNomara S, Yim D, Emerson J, Rosen feId M, Hiatt P, McCoy K, Castile R, Smith AL, Ramsey BW. Longitudinal assessment of Pseudomonas aeruginosa in young children with Cystic fibrosis. J Infect Dis. 2001; 183::444452.
    [Google الباحث العلمي]
  2. Gibson RL, Burns JL, Ramsey BW. Pathophysiology and management of pulmonary infections in cystic fibrosis. Am J Respir Crit Care Med. 2003; 168::918951.
    [Google الباحث العلمي]
  3. Henry R, Mellis C, Petrovic' L. Mucoid Pseudomonas aeruginosa is a marker of poor survival in Cystic fibrosis. Pediatr Pulmonol. 1992; 12::158161.
    [Google الباحث العلمي]
  4. Fegan M, Francis P, Hayward AC, et al., Phenotypic conversion of pseudomonas aeruginosa in Cystic fibrosis. J Clin Microbiol. 1990; 28::11431146.
    [Google الباحث العلمي]
  5. Konstan MW, Morgan WJ, Butler SM, et al., Risk factors for rate of decline in forced expiratory volume in one second in children and adolescent with Cystic fibrosis. J Pediatr. 2007; 151::134139, E131.
    [Google الباحث العلمي]
  6. Li Z, Kosorok MR, Laxova A, et al., Longitudinal development of mucoid Pseudomonas aeruginosa infection and lung disease progression in children with Cystic fibrosis. JAMA. 2005; 293:581588.
    [Google الباحث العلمي]
  7. Hoiby N, Koch C. Cystic fibrosis. 1. Pseudomonas aeruginosa in Cystic fibrosis and its management. Thorax. 1990; 45::881884.
    [Google الباحث العلمي]
  8. Abdul Wahab A, Al Thani G, Dawood ST, Kambouris M, AL Hamed M. Heterogeneity of the Cystic fibrosis phenotype in a large kindred family in Qatar with Cystic fibrosis mutation (11234V). J Trop Pediate. 2001 Apr; 47:2:110112.
    [Google الباحث العلمي]
  9. Banjar H, Kambouris M, Meyer BF, al-Mehaidib A, Mogirri I. Geographic distribution of Cystic fibrosis transmembrance regulator gene mutations in Saudi Arabia. Ann Trop pediatr. 1999 Mar; 19:1:6973.
    [Google الباحث العلمي]
  10. Abdel Rahman H, Abdul Wahab A, Abdel Rahman MO. Fecal elastase 1 concentration in cystic fibrosis patients with CFTR 11234V. Acta Paediatrica. 2006; 95::10661069.
    [Google الباحث العلمي]
  11. Elshafie SS, Abdul Wahab A, Al Janahi I. Antimicrobial resistance of bacterial strains isolated from respiratory tract of Cystic fibrosis patients with CFTRI1234V mutation. Journal of Pediatric infectious Disease.
    [Google الباحث العلمي]
  12. Fitz Simmons S. The changing epidemiology of cystic fibrosis. J Pediatr. 1993; 122::19.
    [Google الباحث العلمي]
  13. Hoiby N, Pedersen SS. Estimated risk of cross infection with of Pseudomonas aeruginosa in Danish cystic fibrosis patients. Acta Paediatr Scand. 1989; 78::395404.
    [Google الباحث العلمي]
  14. Levy H, Kalish LA, Cannon CL, Garcia KC, Gerard C, Goldmann D, Pier GB, Weiss ST, Colin AA. Predictors of mucoid Pseudomonas aeruginosa colonization in cystic fibrosis patients. Pediatr Pulmonol. 2008; 43:5:463471.
    [Google الباحث العلمي]
  15. Demko CA, Byard PJ, Davis PB. Gender differences in Cystic fibrosis: Pseudomonas aeruginosa infection. J Clin Epidemiol. 1995; 48::10411049.
    [Google الباحث العلمي]
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  • نوع المستند: Research Article
الموضوعات الرئيسية CFTRI1 234VCystic Fibrosis and P. aeruginosa

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