1887
Volume 2012, Issue 1
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

ملخص

Abstract The objective was to explore the body mass index (BMI) of women as related to the different parameters of the in vitro fertilization (IVF) procedure and outcome.

This retrospective study on 206 couples analyzed epidemiological features, characteristics of ovarian stimulation and number and quality of retrieved oocytes, as well as pregnancy outcome according to three groups of BMI values: 20>BMI, 28>BMI > 20 and BMI >28 kg/m2.

The prevalence of underweight and overweight women was 15.5% and 41.3%, respectively. The mean ratio of follicle-stimulating hormone to luteinizing hormone increased significantly according to BMI. An increase in the mean number of consummated gonadotropin ampoules together with a decrease in the number of collected oocytes was observed in long stimulation protocol cycles when BMI >28 kg/m2. The same observations were made in short stimulation protocol cycles for 20 > BMI and BMI > 28 kg/m2. No significant relationship could be between clinical pregnancy and miscarriage rates and a patient status as underweight, normal weight, or overweight.

Both underweight and overweight have negative effects on IVF parameters and outcome leading to decreased chances of pregnancy.

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References

  1. Green BB, Weiss NS, Doling JR. Risk of ovulatory infertility in relation to body weight. Fertil Steril. 1988; 50::721726.
    [Google الباحث العلمي]
  2. Zaadstra BM, Seidell JC, Van Noord PAH, Tevelde ER, Habbema JDF, Vrieswijk B, Karbaat J. Fat and female fecundity: Prospective study of effect of body fat distribution on conception rates. Br Med J. 1993; 306::484487.
    [Google الباحث العلمي]
  3. Grodstein F, Goldman M, Cramer D. Body mass index and ovulatory infertility. Epidemiology. 1994; 5::247250.
    [Google الباحث العلمي]
  4. De ’chaud H, Ferron G, Anahory T, Arnal F, Humeau C, He'don B. Obe’ site’ et assistance me’ dicale la procre’ ation. Contracept Fertil Sex. 1998; 26::564567.
    [Google الباحث العلمي]
  5. Clark AM, Thorley B, Tomlinson L, Galletley C, Norman RJ. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum Reprod. 1998; 13::15021505.
    [Google الباحث العلمي]
  6. Brost BC, Goldenberg RL, Mercer BM, lams JD, Meis PJ, Moawad AH, Newman RB, Miodovnik M, Caritis SN, Thurnau GR, Bottoms SF, Das A, McNellis D. The preterm prediction study: Association of cesarean delivery with increases in maternal weight and body mass index. Am J Obstet Gynecol. 1997; 177::333341.
    [Google الباحث العلمي]
  7. Crosignani PG, Ragni G, Parazzini F, Wyssling H, Lombroso G, Perotti L. Anthropometric indicators and response to gonadotrophin for ovulation induction. Hum Reprod. 1994; 9::420423.
    [Google الباحث العلمي]
  8. Zullo F, Di Carlo C, Pellicano M, Catizone C, Mastrantonio P, Nappi C. Superovulation with urinary human follicle-stimulating hormone: Correlations with body mass index and body fat distribution. Gynecol Endocrinol. 1996; 10::1721.
    [Google الباحث العلمي]
  9. Lewis CG, Warnes GM, Wang X, Matthews CD. Failure of body mass index or body weight to influence markedly the response to ovarian stimulation in normal cycling women. Fertil Steril. 1990; 53::10971099.
    [Google الباحث العلمي]
  10. Veeck L. Atlas of the Human Oocyte and Early Conceptus (Vol. 2). Baltimore: Williams & Wilkins 1991.
    [Google الباحث العلمي]
  11. Van Steirteghem A, Nagy Z, Joris H, Liu J, Staessen C, Smitz J, Wisanto A, Devroey P. High fertilization and implantation rates after intracytoplasmic sperm injection. Hum Reprod. 1993; 8::10611066.
    [Google الباحث العلمي]
  12. Lashen H, Ledger W, Lopez Bernal A, Barlow D. Extremes of body mass do not adversely affect the outcome of superovulation and in-vitro fertilization. Hum Reprod. 1999; 14::712715.
    [Google الباحث العلمي]
  13. Singh KB, Mahajan DK, Wortsman J. Effect of obesity on the clinical and hormonal characteristics of the polycystic ovary syndrome. J Reprod Med. 1994; 39::805808.
    [Google الباحث العلمي]
  14. Galtier-Dereure F, Pujol P, Dewailly D, Bringer J. Choice of stimulation in polycystic ovarian syndrome: The influence of obesity. Hum Reprod. 1997; 13:Suppl 1:8896.
    [Google الباحث العلمي]
  15. Mukherjee T, Copperman AB, Lapinski R, Sandler B, Bustillo M, Grunfeld L. An elevated day three follicle-stimulating hormone: Luteinizing hormone ratio (FSH/LH) in the presence of a normal day 3 FSH predicts a poor response to controlled ovarian hyperstimulation. Fertil Steril. 1996; 65::588593.
    [Google الباحث العلمي]
  16. Shepard MK, Balmaceda JP, Leila CG. Relationship of weight to successful induction of ovulation with clomiphene citrate. Fertil Steril. 1979; 32::641645.
    [Google الباحث العلمي]
  17. Dickey RP, Taylor SN, Curole DN, Rye PH, Lu PY, Pyrzak R:. Relationship of clomiphene dose and patient weight to successful treatment. Hum Reprod. 1997; 12::449453.
    [Google الباحث العلمي]
  18. Bray GA. Obesity and reproduction. Hum Reprod. 1997; 12:Suppl. 1:2632.
    [Google الباحث العلمي]
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  • نوع المستند: Research Article

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