1887
Volume 2022, Issue 4
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

ملخص

Background: Back pain is a rare initial presentation of gastric cancer. Isolated back pain with red flags in middle-aged patients might indicate multiple myeloma. However, it is rarely present in advanced gastric adenocarcinoma; hence, data are limited to case reports only. For a timely diagnosis of the underlying malignancy, endoscopy should be considered if the initial workup for this backache is unrevealing.

Case Presentation: We present a 34-year-old previously healthy gentleman with severe unremitting backache. He was ultimately diagnosed with gastric adenocarcinoma stage IV and received palliative treatment. The manuscript also reviewed relevant literature.

Conclusion: In rare cases, gastric malignancy can initially present as back pain with lytic bone lesions, mimicking multiple myeloma. Endoscopy early in the course of investigations may help reduce associated morbidities. Further, more extensive studies are required to understand better the clinical characteristics, demographics, and management of such patients.

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References

  1. Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol. 2019; 14:(1):26–38.
    [Google الباحث العلمي]
  2. Sah JK, Singh YP, Ghimire B. Presentation and Outcomes of Gastric Cancer at a University Teaching Hospital in Nepal. Asian Pac J Cancer Prev. 2015; 16:(13):5385–8.
    [Google الباحث العلمي]
  3. Brigle K, Rogers B. Pathobiology and Diagnosis of Multiple Myeloma. Semin Oncol Nurs. 2017; 33:(3):225–36.
    [Google الباحث العلمي]
  4. Nishidoi H, Koga S. [Clinicopathological study of gastric cancer with bone metastasis]. Gan To Kagaku Ryoho. 1987; 14:(5 Pt 2):1717–22.
    [Google الباحث العلمي]
  5. Park JM, Song KY, O JH, Kim WC, Choi MG, Park CH. Bone recurrence after curative resection of gastric cancer. Gastric Cancer. 2013; 16:(3):362–9.
    [Google الباحث العلمي]
  6. Ameur WB, Belghali S, Akkari I, Zaghouani H, Bouajina E, Jazia EB. Bone metastasis as the first sign of gastric cancer. Pan African Medical Journal. 2017;28.
    [Google الباحث العلمي]
  7. Basheer A, Daniel J, Padhi S. Compressive myeloradiculopathy from bony metastasis as the initial presentation of poorly differentiated adenocarcinoma stomach - A case report. Australasian Medical Journal. 2013; 6:(10):515–9.
    [Google الباحث العلمي]
  8. Becerra-Pedraza LC, Carlos NG, Carmona GRC, Martínez-Piña DA. Uncommon Initial Presentation of Gastric Cancer with Bone Metastases: a Case Report. Journal of Gastrointestinal Cancer. 2019; 50:(2):334–7.
    [Google الباحث العلمي]
  9. Burroughs S, Post R, James E. Metastatic Gastric Signet Ring Cell Adenocarcinoma Masquerading as Low Back Pain. Cureus. 2020; 12:(11):e11297.
    [Google الباحث العلمي]
  10. Chitty A, Cardriche D, Matese TH Jr, . Gastric Adenocarcinoma Presenting as Chronic Back Pain: A Case Report. Clin Pract Cases Emerg Med. 2020; 4:(2):201–4.
    [Google الباحث العلمي]
  11. Dittus C, Mathew H, Malek A, Negroiu A. Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma. Journal of Gastrointestinal Oncology. 2014; 5:(6):E113–E6.
    [Google الباحث العلمي]
  12. Fan P, Wang Q, Lu C, Chen D. Generalized high bone mineral density on bone density scanning: a case of gastric carcinoma with bone metastasis. Postgraduate Medicine. 2017; 129:(2):299–303.
    [Google الباحث العلمي]
  13. Fujita I, Toyokawa T, Makino T, Matsueda K, Omote S, Horii J. Small early gastric cancer with synchronous bone metastasis: A case report. Molecular and Clinical Oncology. 2020; 12:(3):202–7.
    [Google الباحث العلمي]
  14. George J, Johnson DK, Rajan RA, Kolassery S, Thazhath RM. An unusual presentation of carcinoma stomach. Pan African Medical Journal. 2013;14.
    [Google الباحث العلمي]
  15. Guvendi B, Sade R, Yuce I, Karaca L, Ogul H, Kantarci M. Unusual presentation of gastric carcinoma: back pain. Spine J. 2015; 15:(10):e41.
    [Google الباحث العلمي]
  16. Hirose K, Tamaki M, Senda K, Hirono Y, Iida A, Katayama K, et al. A gastric cancer patient with multiple bone metastasis who survived for long term period with postoperative combined chemoradiotherapy. Japanese Journal of Gastroenterological Surgery. 2001; 34:(12):1732–6.
    [Google الباحث العلمي]
  17. Hussain S, Chui S. Gastric carcinoma presenting with extensive bone metastases and marrow infiltration causing extradural spinal haemorrhage. British Journal of Radiology. 2006; 79:(939):261–3.
    [Google الباحث العلمي]
  18. Mandato VD, Pirillo D, Gelli MC, Cavina M, La Sala GB. Gastric cancer in a pregnant woman presenting with low back pain and bilateral erythematous breast hypertrophy mimicking primary inflammatory breast carcinoma. Anticancer Research. 2011; 31:(2):681–5.
    [Google الباحث العلمي]
  19. Sandilya S, Golestaneh L. A Rare Presentation of AKI: Gastric Infiltration of the Bladder Wall. Case Rep Nephrol. 2011;2011:387649.
    [Google الباحث العلمي]
  20. Ushida H, Johnin K, Koizumi S, Takeda S, Kaneko K, Endo K, et al. Three cases of gastric cancer (Borrmann type IV) presenting with right back pain caused by right hydronephrosis as the first symptom. Hinyokika kiyo Acta urologica Japonica. 1999; 45:(10):729–32.
    [Google الباحث العلمي]
  21. Wanebo HJ, Kennedy BJ, Chmiel J, Steele G jr., Winchester D, Osteen R. Cancer of the stomach. A patient care study by the American College of Surgeons. Ann Surg. 1993; 218:(5):583–92.
    [Google الباحث العلمي]
  22. Maconi G, Manes G, Porro GB. Role of symptoms in diagnosis and outcome of gastric cancer. World J Gastroenterol. 2008; 14:(8):1149–55.
    [Google الباحث العلمي]
  23. Maconi G, Kurihara H, Panizzo V, Russo A, Cristaldi M, Marrelli D, et al. Gastric cancer in young patients with no alarm symptoms: focus on delay in diagnosis, stage of neoplasm and survival. Scand J Gastroenterol. 2003; 38:(12):1249–55.
    [Google الباحث العلمي]
  24. Stephens MR, Lewis WG, White S, Blackshaw GRJC, Edwards P, Barry JD, et al. Prognostic significance of alarm symptoms in patients with gastric cancer. British Journal of Surgery. 2005; 92:(7):840–6.
    [Google الباحث العلمي]
  25. Bowrey DJ, Griffin SM, Wayman J, Karat D, Hayes N, Raimes SA. Use of alarm symptoms to select dyspeptics for endoscopy causes patients with curable esophagogastric cancer to be overlooked. Surg Endosc. 2006; 20:(11):1725–8.
    [Google الباحث العلمي]
  26. Siewert JR, Böttcher K, Stein HJ, Roder JD. Relevant prognostic factors in gastric cancer: ten-year results of the German Gastric Cancer Study. Ann Surg. 1998; 228:(4):449–61.
    [Google الباحث العلمي]
  27. Hussain S, Chui S. Gastric carcinoma presenting with extensive bone metastases and marrow infiltration causing extradural spinal haemorrhage. Br J Radiol. 2006; 79:(939):261–3.
    [Google الباحث العلمي]
  28. Hironaka SI, Boku N, Ohtsu A, Nagashima F, Sano Y, Muto M, et al. Sequential methotrexate and 5-fluorouracil therapy for gastric cancer patients with bone metastasis. Gastric Cancer. 2000; 3:(1):19–23.
    [Google الباحث العلمي]
  29. Fujita I, Toyokawa T, Makino T, Matsueda K, Omote S, Horii J. Small early gastric cancer with synchronous bone metastasis: A case report. Mol Clin Oncol. 2020; 12:(3):202–7.
    [Google الباحث العلمي]
  30. Yoshikawa K, Kitaoka H. Bone metastasis of gastric cancer. Jpn J Surg. 1983; 13:(3):173–6.
    [Google الباحث العلمي]
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  • نوع المستند: Case Report
الموضوعات الرئيسية Back painGastric cancerMetastatic Malignancy and Multiple Myeloma

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